Navigation Links
Bacteria have their own immune system protecting against outside DNA

Bacteria like Salmonella have a complicated immune system that helps them recognize and isolate foreign DNA trying to invade their cell membrane, according to a University of Washington-led study in the June 8 issue of Science Express. The research, which also included scientists at the Sidney Kimmel Cancer Center in San Diego, could have major implications for understanding the evolution of disease-causing bacteria. The findings may also impact the biotech industry, where bacteria are used to produce recombinant human proteins for medical treatments and research.

A group of researchers led by Dr. Ferric Fang, professor of laboratory medicine and microbiology at the UW School of Medicine, were interested in learning how bacteria respond to genetic information coming from outside sources. Just as immune cells recognize and attack foreign invaders in the human body to protect against harmful infections, single-cell organisms have a protein called H-NS that recognizes foreign DNA and prevents it from becoming active, the researchers discovered.

But bacteria can also benefit from foreign DNA. When Salmonella is infecting an animal or person, for instance, many proteins the bacteria need to cause disease are encoded by DNA acquired from other bacteria. The researchers found that when the bacteria is infecting a host, other molecules can compete with the H-NS protein, allowing the disease-causing genes to be expressed. When the bacteria are in the environment, H-NS turns these genes off to avoid detrimental consequences if all the disease-causing genes were to be expressed at once.

These findings give scientists new insight into how bacteria can protect themselves from an invasion by foreign DNA, yet still take in genetic information from diverse sources that makes them more virulent.

"By harnessing foreign DNA, bacteria that cause typhoid, dysentery, cholera and plague have evolved from harmless organisms into feared pathogens," explained
'"/>

Source:University of Washington


Page: 1 2

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
(Date:8/21/2014)... feeding tube connectors, designed by an international standards process, ... , According to an invited review published in the ... ( NCP ), the official journal of the American ... connectors will greatly reduce the occurrence of misconnection that ... Small-bore connectors, which are used to join medical devices, ...
(Date:8/21/2014)... successfully replicated one of the crucial steps in photosynthesis, ... which could manufacture hydrogen as a fuel. , "Water ... exciting prospect to use them to create hydrogen, and ... from the ARC Centre of Excellence for Translational Photosynthesis ... offers potential as a zero-carbon replacement for petroleum products, ...
(Date:8/21/2014)... in severe abdominal pain, vomiting and systemic inflammation. Every ... with the disease resulting in 1000 deaths. There is ... fluid and nutritional support. , Dr Jason Bruce, ... research, said "The major causes of pancreatitis include bile ... combined with a high fat diet. In fact, the ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Water and sunlight the formula for sustainable fuel 2Insulin offers new hope for the treatment of acute pancreatitis 2
... NY, October 13, 2010Parents of children with undiagnosed learning ... of psychological and social challenges, which are explored in ... and Molecular Biomarkers , a peer-reviewed journal published by ... is available free online ahead of print at ...
... solved an important mystery about why an arsenic compound, ... an effective therapeutic agent against disease and infections. According ... of Genetics ( http://www.genetics.org ) scientists from ... common water contaminant in many parts of the world, ...
... new study conducted by a researcher at Ben-Gurion University ... Social Policy Studies in Israel reports that Israeli,s have ... residents of other OECD (Organization for Economic Cooperation and ... from 2005, the average American life expectancy is now ...
Cached Biology News:Unexplained childhood disorders 2Scientists solve mystery of arsenic compound 2Life expectancy higher in Israel than in US, according to Ben-Gurion U. researcher 2
(Date:8/21/2014)... 21, 2014 Mathematic studies at the Program ... and funded by the Jeffrey Epstein VI Foundation , ... be visually identified for elimination. These aggressive cells are the ... shows a topological map of what to look for when ... for while tumor cells can be extracted from biopsy, it,s ...
(Date:8/21/2014)... Ontotext S4 , The Self Service Semantic ... Now the same enterprise hardened text mining, Linked Data ... is available to start-ups and mid-size businesses at a ... do not have resources to evaluate and prototype enterprise ... there is no need for on premise hardware provisioning ...
(Date:8/20/2014)... to biotechnology firms has revealed early bottlenecks on ... the researchers suggest that better communication of basic ... to faster commercialization down the road. , Biopharmaceutical ... university laboratories and licensed to biotechnology firms. Bottlenecks ... a high failure rate. But a new study ...
(Date:8/20/2014)... Mass. , Aug. 20, 2014  Decision Resources Group finds ... , Russia , India ... $1.6 billion in 2013, roughly equal to the size of ... however, the BRIC market will experience much faster growth as a ... aging population. Other key findings from Decision Resources Group,s ...
Breaking Biology Technology:Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3
... Calif., March 9 Cord Blood America, Inc. (OTC ... preservation company ( http://www.cordblood-america.com ) focused on bringing ... nationwide and internationally, said today that it believes the ... on Federal funding of stem cell research is a ...
... YORK, March 9 Cynvec LLC, a privately held ... harness the apoptotic ability of the sindbis viral vector, ... Officer, will present at the Cowen and Company 29th ... 16, 2009 at 4:00 p.m. ET. About ...
... CAMBRIDGE, Mass., March 9 Merrimack Pharmaceuticals, Inc., a ... development of novel treatments for cancer and autoimmune disease, ... to Senior Vice President and Chief Scientific Officer and ... Business Development. "Ulrik and Tad have both played ...
Cached Biology Technology:Cord Blood America Sees Significant Positives in President Obama's Lifting of Stem Cell Funding Restrictions 2Merrimack Pharmaceuticals Promotes Ulrik B. Nielsen, Ph.D. to Chief Scientific Officer and Edward J. Stewart to Senior Vice President of Business Development 2
... materials for 1,464 array sample elements. , , ,Includes: ... , Blocker BSA in PBS (10X): 50 ml ... Phosphate Buffered Saline: 8 packs , 10% Tween-20: ... Luminol Enhancer: 2 x 25 ml , SuperSignal West ...
... Counter Analyser counts cells based on specific ... only cells, so that other non cellular ... through a 250 m square quartz cuvette ... which is used as a counting signal ...
... Accurate Results Laser Capture Microdissection (LCM) ... and accuracy of molecular assays by starting ... multi-cellular structures isolated from whole tissue or ... in 1996 at the National Institutes of ...
Mouse monoclonal antibody raised against a partial recombinant DHX8. NCBI Entrez Gene ID = DHX8...
Biology Products: