Navigation Links
Bacteria ferry nanoparticles into cells for early diagnosis, treatment

at are drawn into the cell's interior. Once inside the cell, the bacteria dissolve the vesicle membrane and release the cargo.

The method might be used to take images of diseased tissues by inserting a cargo of fluorescent molecules into tumors that are ordinarily too small to be detected, said Demir Akin, a research assistant professor of biomedical engineering who specializes in nanomedicine.

"These bacteria can potentially deliver specific molecules into a variety of cells," said Akin, the first author of a research paper appearing online this week in the journal Nature Nanotechnology.

Experiments were carried out in cultures of human cancer cells, including intestinal, oral, liver, ovarian and breast cancer cells. The researchers also tested their method on live mice and showed how the technique could be used to deliver specific genes to various organs, including the liver and kidneys.

"The cells in the organs receiving the bacteria with nanoparticles made the intended therapeutic proteins and emitted a light similar to a firefly's glow," Akin said.

Certain bacteria are naturally programmed to dissolve vesicle membranes, a critical step to delivering the cargo. The nanoparticles are referred to as "smart" because they release their cargo at precisely the right moment after entering the cell.

"At the same time that the bacteria are breaking up this vesicle membrane, the cargo dislodges from the bacteria, which are both crucial steps in delivering this cargo," Akin said.

The nanoparticles, which range in size from 40 to 200 nanometers - or billionths of a meter - are attached to the bacteria with "linker molecules."

"The use of commercially available polystyrene nanoparticles makes this delivery system much simpler to implement than previous alternatives," Bashir said.

This new delivery system also is more efficient than other experimental techniques using viruses and bacteri
'"/>

Source:Purdue University


Page: 1 2 3

Related biology news :

1. Bacteria collection sheds light on urinary tract infections
2. Solution to Pollution: New Bacteria Eats Toxic Waste
3. The Bacterias guide to survival
4. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Where Bacteria Get Their Genes
7. Bacteria feed on smelly breath (and feet)
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Bacteria use hosts immune response to their competitive advantage
10. Say what? Bacterial conversation stoppers
11. Bacteria are key to green plastics, drugs
Post Your Comments:
(Date:10/30/2014)... University researchers have developed a suite of technologies that ... humans, which has applications in everything from search and ... "We,ve developed a platform for computer-mediated communication between humans ... for interpreting dogs, behavioral signals and sending them clear ... an assistant professor of computer science at NC State ...
(Date:10/29/2014)... who lose their hair as a consequence of chemotherapy ... improve the scalp cooling technology that prevents hair loss. ... being pioneered by global scalp cooling manufacturing company, Paxman ... biology department of the University of Huddersfield. , The ... who has a background in the pharmacology of cancer ...
(Date:10/29/2014)... factors, both genetic and environmental, have been blamed ... schizophrenia. Some, such as a family history of ... with Toxoplasma gondii , a parasite transmitted ... still viewed with skepticism. , A new study ... epidemiology at the University of Pennsylvania,s School of ...
Breaking Biology News(10 mins):New tech aims to improve communication between dogs and humans 2New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3
... have found that a strain of tuberculosis (TB) responsible ... first introduced to these communities by French Canadian fur ... found a traceable link between the fur trade routes ... professor with Queen,s Division of Infectious Diseases, is the ...
... Melding nanotechnology and medical research, Sandia National Laboratories, the ... and Treatment Center have produced an effective strategy that ... of killer drugs. , In the cover article of ... online April 17 , the researchers describe silica nanoparticles ...
... Monday, April 18, 2011, Cleveland: Researchers have identified ... as the cause of a fatal developmental disease in ... April 8, 2011, issue of Science . ... the cellular protein-making process, causing microcephalic osteodysplastic primoridal dwarfism ...
Cached Biology News:Tuberculosis strain in indigenous communities linked to Canadian fur trade 2Sandia and UNM lead effort to destroy cancers 2Sandia and UNM lead effort to destroy cancers 3Genetic mutation linked to lethal disease 2
(Date:10/30/2014)... James Sherley says he has been working ... cell technology since his days as a principal investigator at ... late 1990’s. Sherley founded the ASCTC as a new ... the intellectual property developed in Sherley’s research over the years ... of Technology (MIT), and more recently as a senior scientist ...
(Date:10/30/2014)... 30, 2014 Grace Century portfolio project, ... Manganello, Chairman of the Board, to the National Stem ... appointment was made by the Ministry of Health on behalf ... , More than a year after Bahamian Parliament ... Prime Minister Perry Christie said the government has completed the ...
(Date:10/30/2014)... of the key challenges in the development of quantum ... , In a paper published today (28 October) in ... show how to make a new type of flexibly ... such as high-precision sensors and specialised superfast computers, often ... the methods for trapping these tiny particles are hugely ...
(Date:10/27/2014)... , October 27, 2014 ... right to produce, exhibit and sell its artificial ... to impeach their patent.      (Photo: ... four years of fighting, the definitive judgement has ... and produces innovative and accessible hi-tech prostheses with ...
Breaking Biology Technology:Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2
... NeuroCog Trials, Inc. today announced the appointment of Michael ... Officer.  In this newly created position, Dr. Hufford will ... NeuroCog Trials, business, research and development, and operations. ... therapies across a wide variety of therapeutic areas has ...
... November 4, 2011 Major milestone achieved ... treatment of patients with refractory ascites due to liver ... Vienna and Vienna General Hospital (AKH Wien) reported that ... System were performed at Vienna General Hospital in October, ...
... Nov. 3, 2011 Sequenom, Inc. (NASDAQ: SQNM ), ... total revenues of $13.6 million for the third quarter of 2011, ... the third quarter of 2010.  Net loss for the third quarter ... to net loss of $22.7 million, or $0.30 per share for ...
Cached Biology Technology:NeuroCog Trials Appoints Industry Executive Michael Hufford, Ph.D. to Chief Operating Officer 2The Medical University of Vienna and Vienna General Hospital Perform the First two Commercial Implants Worldwide of Sequana Medical's ALFApump® System 2Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 2Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 3Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 4Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 5Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 6Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 7Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 8
Chicken Anti-Human Stomatin-like 2 (STOML2 Polyclonal AntibodyNew Applications: ELISA, Western Blot...
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
... (Ankyrin repeat and SOCS box-containing protein) This ... containing amino acids 75-93 and 348-368 of ... Catalog No. 40149) can be used as ... with mouse and rat Asb-2, based on ...
Monoclonal Anti-Gα o purified immunoglobulin buffered aqueous solution Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide. partially purified bovine brain Gα O ...
Biology Products: