Navigation Links
Baby's genes affect mom's cholesterol levels

A group of Belgian researchers has determined that a pregnant woman's ability to metabolize fats is determined not only by her genes but by her baby's genes as well. The details of their findings appear in the November issue of the Journal of Lipid Research, an American Society for Biochemistry and Molecular Biology journal.

The researchers, led by Olivier S. Descamps of the Centre de Recherche Medicale de Jolimont in Haine Saint-Paul and of the Universite Catholique de Louvain in Brussels, studied genes and proteins involved in fat metabolism from the blood and placenta of 525 pregnant women. Because all cells from the placenta originate from the fetus, they are a good indication of the genes and proteins produced by the baby.

Descamps and his co-workers discovered that the baby's genes had almost as much influence as the mother's genes on her lipoprotein levels. Because increased levels of lipoproteins can lead to pre-eclampsia and pancreatitis in pregnant women and also increase their future risk of cardiovascular disease, these findings are of particular interest to the medical community.

"The lipoprotein particle is composed of proteins called apolipoproteins and lipids such as cholesterol and triglycerides." explains Descamps. "Lipoproteins represent the only way for lipids, which are insoluble in water, to be transported through the blood circulation, composed exclusively of water."

The study focused on two specific proteins involved in lipid metabolism, lipoprotein lipase and apolipoprotein E. "Apolipoprotein E and lipoprotein lipase play important roles in the degradation of triglyceride-rich lipoproteins," notes Descamps. "In pregnant women, the concentrations of these lipoproteins are particularly very high and it is thought that these lipoproteins are the forms that carry the lipids to the placenta.

The researchers looked at several genetic variations (also known as polymorphisms) of lipoprotein lipase and apoli poprotein E that are known to influence the concentrations of triglycerides and cholesterol in the general population. They found that when these polymorphisms were present in the babies, their mothers' triglyceride and cholesterol levels were influenced to the same extent that they would be if the polymorphisms were present in the mothers. However, when both the mother and fetus expressed the same polymorphism, the results were not always as predicted. For example, a genetic variation that raises the levels of triglycerides and cholesterol when expressed in mothers may lower these levels when it is expressed simultaneously by the fetus in the placenta.

These findings have implications for many women who are advised not to have children due to genetic defects in lipoprotein metabolism. Because their fetuses can compensate for their defects, the women may actually be able to bear children without complications.


'"/>

Source:American Society for Biochemistry and Molecular Biology


Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Inexpensive, mass-produced genes core of synthetic biology advances at UH
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. U-M scientists find genes that control growth of common skin cancer
5. Researchers find missing genes of ancient organism
6. Scientists document complex genomic events leading to the birth of new genes
7. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
8. Advances in the characterisation of the oyster mushroom genes
9. Researchers find new genes necessary to make embryo
10. Protein helps regulate the genes of embryonic stem cells
11. Compounds in plastic packaging act as environmental estrogens altering breast genes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica ... in people with peritoneal or pleural mesothelioma. Their findings are the subject of a ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: