Navigation Links
Avian influenza survivors' antibodies effective at neutralising H5N1 strain

Adults who have recovered from the potentially deadly H5N1 strain of avian influenza may hold the key to future treatments for the virus, according to an international team of researchers. In a study published today in the open access journal PLoS Medicine, the researchers have shown how specific antibodies taken from avian flu survivors in Vietnam can be reproduced in the laboratory and prove effective at neutralising the virus in culture vitro and in mice.

The H5N1 influenza virus has caused disease and death in millions of poultry across the globe and occasionally has been transmitted to humans, often fatally. By mid-May 2007, according to the World Health Organization, there had been 306 known cases in humans, 185 of them fatal.

Now, doctors based at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam, the Institute for Research in Biomedicine in Bellinzona, Switzerland and the National Institute of Allergy and Infectious Diseases in Bethesda, US, have shown that monoclonal antibodies generated from blood of human survivors of the H5N1 virus are effective at both preventing infection in mice and neutralising the virus in those already infected. The research had been fast-tracked for funding by the UK's Wellcome Trust and is also supported by grants from the National Institutes of Health in the US and the Swiss National Science Foundation.

The researchers found that the antibodies provided significant immunity to mice that were subsequently infected with the Vietnam strain of H5N1. This reduced significantly the amount of virus found in the lungs and almost completely prevented the virus reaching the brain or spleen. In those people in Vietnam who died from the H5N1 strain, the virus was found to have spread from the lungs; this was not the case in those who survived.

"We have shown that this technique can work to prevent and neutralise infection by the H5N1 'bird flu' virus in mice," says Dr Cameron Simmons, a
'"/>

Source:Wellcome Trust


Page: 1 2

Related biology news :

1. NIAID Initiates Trial of Experimental Avian Flu Vaccine
2. Avian influenza virus in mammals spreads beyond the site of infection to other organ systems
3. Avian flu transmission to humans may be higher than thought
4. Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic
5. Computers to be used to find blueprint for new influenza drug
6. Less virulent strains of avian influenza can infect humans
7. Drug resistant avian influenza viruses more common in Southeast Asia than North America
8. New vaccine platform may fight infections with causes from influenza to bioterrorism
9. First big influenza genome study reveals flu evolution
10. Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
11. New influenza vaccine takes weeks to mass produce
Post Your Comments:
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 Based ... 5S, Samsung introduces for the first time a fingerprint ...
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ...
(Date:12/15/2014)... and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) has announced ... 2015-2019" report to their offering. ... a technology used for the identification of individuals. Facial ... person such as nose, jaw edges, mouth, and the ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... of the marine food chain, albatrosses accumulate toxic contaminants ... A new study has found dramatic differences in contaminant ... in different areas of the North Pacific. Researchers also ... in both species over the past ten years. , ...
... scrubbing off and discarding the outer layer of long-grain ... the first time, scientists in Japan have shown that ... significantly lowers blood pressure in rats whose hypertension resembles ... in the March 8 issue of the Journal ...
... a blueprint for boosting anti-cancer drugs' effectiveness and lowering ... sinker onto the drugs. This extra weight makes the ... Chemotherapy drugs often fall short of achieving their full ... the tumor too rapidly, said the scientists from Duke ...
Cached Biology News:Albatross study shows regional differences in ocean contamination 2Albatross study shows regional differences in ocean contamination 3How nice, brown rice: Study shows rice bran lowers blood pressure in rats 2Weighting cancer drugs to make them hit tumors harder 2Weighting cancer drugs to make them hit tumors harder 3Weighting cancer drugs to make them hit tumors harder 4
(Date:12/24/2014)... 23, 2014 GMO corn cases filed across ... in the process of being consolidated in a Kansas federal ... Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 in ... Management of the Syngenta GMO corn multidistrict litigation (MDL) has ...
(Date:12/24/2014)... December 23, 2014 SoundConnect’s ... to introduce cutting edge communication technology, provide continued ... upgrades. This webinar series demonstrates online communication features ... leverage web conferencing’s most innovative and powerful tools. ...
(Date:12/24/2014)... According to Ross Selinger, President of Selinger ... the national office market continues to be strong, driven by ... by the third quarter’s surprising 3.9% GDP, unemployment decreasing to ... have held inflation down and the Fed is keeping interest ...
(Date:12/24/2014)... Nashville, Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for Reproductive Medicine ... research in reproductive medicine. In his new role as ... board and will have a voice in furthering the mission ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... Neogen Corporation (Nasdaq: NEOG ) announces ... Results WebcastWhen: Thursday, March 19, 2009 @ ... Live over the Internet -- Simply log on ... Contact: Terry Maynard of Neogen Corporation, +1-800-234-5333.If ...
... expands to EU, LATAM and AfricaSAINT JOHN, New Brunswick, ... immediate availability of ThyroChek, the rapid test for elevated ... in the European Union. Until now, it has only ... test for adults to the 200,000 physician office labs. ...
... Inc. (Nasdaq: INSM ), a developer of follow-on biologics (FOB) and ... Company Highlights , , ... Insmed entered into a definitive agreement with ... related to Insmed,s follow-on biologics platform. , ...
Cached Biology Technology:SD Canada Announces CE Mark for ThyroChek(R) Adult and NeoNatal Tests 2Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 2Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 3Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 4Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 5Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 6Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 7Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 8Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 9Insmed Announces Fourth Quarter and Full-Year 2008 Financial Results 10
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Rabbit Anti-Mouse Ym1 Polyclonal Antibody,...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
... Analysis of large numbers of samples may ... system which requires minimum operator attention. ... PowerStream software and interface CE 4900. The ... operates in Windows XP and Windows 98 and ...
Biology Products: