Navigation Links
Attacks of King George III's madness linked to key metabolism molecule

ited mutations that disrupt the body's manufacture of heme. A reddish pigment that contains iron, heme is a building block of the oxygen-carrying hemoglobin in red blood cells. The complex synthesis requires eight different enzymes, and when any of them is deficient because of a mutation, the process is blocked. The resulting back up of "precursor" substances is toxic, and can cause a range of symptoms, including dark colored urine, abdominal pain, nausea, vomiting, constipation, weakness in the limbs, and psychiatric symptoms such as confusion, fits and hallucinations.

Earlier this year, the British journal Lancet published a report saying that a test of strands of George III's hair contained arsenic, which can provoke porphyria attacks. The authors of that report suggested that, ironically, he may have been exposed to arsenic contamination of a substance his doctors gave him as treatment.

PGC-1 alpha is a "transcriptional coactivator" that acts as an on-off switch for a number of genes involved in manufacture of glucose in the liver and in the "heating system" of brown fat cells that help prevent damage from cold in certain animals.

With their intimate knowledge of PGC-1 alpha and its varied roles in energy metabolism, the Dana-Farber researchers wondered if it might be involved in porphyria, since PGC-1 alpha is a regulator of heme manufacture in the liver. One of its actions is controlling the activity of the ALAS-1 gene that makes a protein that's crucial to the normal manufacture of heme. A defect in this genetic signaling pathway could cause ALAS-1 to accumulate in high levels, leading to the symptoms of porphyria attacks.

"We found that PGC-1 alpha is an important factor controlling the expression of ALAS-1 in the fasted and fed liver," the authors write. "Moreover, we showed that hepatic [in the liver] PCG-1 alpha is a major determinant of the severity of acute porphyric attacks in mouse models of chemical porphyria."

<
'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2 3

Related biology news :

1. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Low level of extinction during ice age linked to adaptability
4. Improved statistical tools reveal many linked loci
5. Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
6. Gene controlling circadian rhythms linked to drug addiction
7. Physical and functional interaction of key cell growth molecules linked to cancer
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Naturally occurring asbestos linked to lung cancer
10. Disappearing arctic lakes linked to climate change
11. Genes linked to treatment resistance in children with leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Attacks King George III madness linked key metabolism molecule

(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... to survive? The answer changes depending on climate, and some ... sprouts. Stanford researchers have found that the formation of ... meaning mouth) is controlled by a specific signaling pathway that ... The findings are described in a paper published Nov. 14 ...
... Nov. 24 M2SYS Technology, an award-winning,fingerprint ... that,InvoTech Systems Inc., the leading provider of ... industry, has chosen M2SYS Technology to,provide ... software and with M2SYS, M2-EasyScan(TM) optical fingerprint,reader. ...
... (NIST) announced today that it is awarding grants totaling ... cost-shared support for the construction of new scientific research ... in a special competition announced last spring. The ... the University of California at Berkeley for the build-out ...
Cached Biology News:Key link in how plants adapt to climate discovered by Stanford researchers 2InvoTech Selects M2SYS Technology for Leading-Edge Fingerprint Software Solution 2NIST awards $24M in grants for new research facilities 2NIST awards $24M in grants for new research facilities 3NIST awards $24M in grants for new research facilities 4NIST awards $24M in grants for new research facilities 5
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: PTBI, ... announced the closing of an underwritten public offering of 3,500,000 ... an aggregate 3,500,000 shares of common stock, at an offering ... warrants have a per share exercise price of $5.00, are ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... designed to introduce cutting edge communication technology, provide ... platform upgrades. This webinar series demonstrates online communication ... to leverage web conferencing’s most innovative and powerful ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... February 29, 2012 TREM Rx, Inc., a biotechnology ... to the skin, announced today the results of an in ... powerful cells of the immune system called TREMs (T Resident ... protective immune response that is far stronger than memory T ...
... has been shown to significantly improve the chances of pregnancy ... a Newcastle team of fertility experts at the University and ... a totally enclosed and controlled environment within which every step ... published today in the journal PLoS ONE reveals ...
... 2012 ARUP Laboratories, a leading national clinical and ... laboratory research and development, announced the establishment of a ... ) The new division is designed to ... enhance our ability to diversify into new market segments. ...
Cached Biology Technology:Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 2Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 3Increased fertility rate for IVF patients achieved by new equipment design 2ARUP Laboratories Announces Creation of Business Innovations Division 2
2'-Fluorine-CTP (2'-F-CTP) is readily incorporated into transcripts by T7 and SP6 R&DNA™ Polymerase and is available separately....
... J. Karn (1995) This ... information and methods for the study of ... cycle; reverse transcriptase, ribonuclease H, integrase and ... RNA binding assays; Tat and Rev assays; ...
Human Glypican 2 Biotinylated Affinity Purified PAb...
Human Contactin-2/TAG1 Affinity Purified Polyclonal Ab...
Biology Products: