Navigation Links
Attacks of King George III's madness linked to key metabolism molecule

ited mutations that disrupt the body's manufacture of heme. A reddish pigment that contains iron, heme is a building block of the oxygen-carrying hemoglobin in red blood cells. The complex synthesis requires eight different enzymes, and when any of them is deficient because of a mutation, the process is blocked. The resulting back up of "precursor" substances is toxic, and can cause a range of symptoms, including dark colored urine, abdominal pain, nausea, vomiting, constipation, weakness in the limbs, and psychiatric symptoms such as confusion, fits and hallucinations.

Earlier this year, the British journal Lancet published a report saying that a test of strands of George III's hair contained arsenic, which can provoke porphyria attacks. The authors of that report suggested that, ironically, he may have been exposed to arsenic contamination of a substance his doctors gave him as treatment.

PGC-1 alpha is a "transcriptional coactivator" that acts as an on-off switch for a number of genes involved in manufacture of glucose in the liver and in the "heating system" of brown fat cells that help prevent damage from cold in certain animals.

With their intimate knowledge of PGC-1 alpha and its varied roles in energy metabolism, the Dana-Farber researchers wondered if it might be involved in porphyria, since PGC-1 alpha is a regulator of heme manufacture in the liver. One of its actions is controlling the activity of the ALAS-1 gene that makes a protein that's crucial to the normal manufacture of heme. A defect in this genetic signaling pathway could cause ALAS-1 to accumulate in high levels, leading to the symptoms of porphyria attacks.

"We found that PGC-1 alpha is an important factor controlling the expression of ALAS-1 in the fasted and fed liver," the authors write. "Moreover, we showed that hepatic [in the liver] PCG-1 alpha is a major determinant of the severity of acute porphyric attacks in mouse models of chemical porphyria."

<
'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2 3

Related biology news :

1. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Low level of extinction during ice age linked to adaptability
4. Improved statistical tools reveal many linked loci
5. Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
6. Gene controlling circadian rhythms linked to drug addiction
7. Physical and functional interaction of key cell growth molecules linked to cancer
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Naturally occurring asbestos linked to lung cancer
10. Disappearing arctic lakes linked to climate change
11. Genes linked to treatment resistance in children with leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Attacks King George III madness linked key metabolism molecule

(Date:7/30/2015)... , July 30, 2015 Cellecta, ... for gene function analysis and biomarker discovery, announced ... (sgRNA) Knockout Library targeting all human protein coding ... permanently "knock out" a gene,s function. Cellecta,s new ... high throughput screening tool so that researchers can ...
(Date:7/27/2015)... ANGELES , July 27, 2015   ... evidence- and experience-based clinical improvement solutions, today announced ... solution is now available on Android smartphones and ... inpatient and post-care organizations can use ZynxCarebook to ... same patient,s condition, streamline care transitions to other ...
(Date:7/23/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) has ... of the Biometrics Industry 2015 " report ... biometrics market is likely to witness significant growth ... the uptake of multiple technologies available. The year ... growth of biometrics in existing applications as well ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... GSA BULLETIN science published online 9-20 March includes ... the Southern Pyrenees, and the western Gulf of Mexico. ... in south-central Chile, characterizing the source and age of ... pieces of mid-oceanic ridge found above ground, and large ...
... associated with storing nuclear waste and the possibility of ... may no longer be obstacles on the road to ... the University of Notre Dame, led by Thomas E. ... concurrent professor of chemistry and biochemistry, showcases Notre Dame ...
... WASHINGTON The water flowing through Venice,s famous canals ... not only because of a rising sea level. Although previous ... that the historic city continues to slowly sink, and even ... be continuing to subside, at a rate of about 2 ...
Cached Biology News:How old are these rocks, how were they made, and how long ago did these geologic changes happen? 2How old are these rocks, how were they made, and how long ago did these geologic changes happen? 3How old are these rocks, how were they made, and how long ago did these geologic changes happen? 4How old are these rocks, how were they made, and how long ago did these geologic changes happen? 5How old are these rocks, how were they made, and how long ago did these geologic changes happen? 6How old are these rocks, how were they made, and how long ago did these geologic changes happen? 7New paper by Notre Dame researchers describes method for cleaning up nuclear waste 2AGU: Venice hasn't stopped sinking after all 2AGU: Venice hasn't stopped sinking after all 3AGU: Venice hasn't stopped sinking after all 4
(Date:8/4/2015)... -- Trigemina, Inc., a biopharmaceutical company focused on the ... products, announced today that the company has appointed Shashidhar ... officer. Dr. Kori brings over 30 years of clinical ... focused in the neuroscience and headache space. ... clinical team given his vast experience managing clinical development ...
(Date:8/4/2015)... ... August 04, 2015 , ... On August 4, 2015, the White ... of entrepreneurs from across the United States to talk about their experiences with innovation ... be chosen to be among the attendees. , One of the day’s aims is ...
(Date:8/3/2015)... , August 3, 2015 At ... Portland Hospital waved the shortfall of Jude ... stand normally for the first time.      ... http://photos.prnewswire.com/prnh/20150803/254229 ) The Selective Dorsal ... allowing him to carry out his wish to kick ...
(Date:8/3/2015)... -- Aethlon Medical, Inc. (Nasdaq: AEMD ), the pioneer ... today announced that it will host its First Quarter ... August 13, 2015 at 4:30 p.m. Eastern Time. ... of fiscal 2016 first quarter results.  A recorded version ... after the call at the Investor Relations portion of ...
Breaking Biology Technology:Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 2Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 3White House Invites uBiome CEO Jessica Richman to First-Ever Startup Demo Day 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2
... FRAZER, Pa., Dec. 6, 2010 Cephalon, Inc. (Nasdaq: ... company,s Chairman and Chief Executive Officer, will not be ... will remain on a medical leave of absence indefinitely.  ... Operating Officer, will continue to perform Dr. Baldino,s day-to-day responsibilities ...
... Dec. 6, 2010 Investigators report no evidence of toxicity ... a gene therapy trial using a vector under development ... College London) to correct the inherited bleeding disorder. ... with low and intermediate doses of the vector expected to ...
... SIGNAL HILL, Calif., Dec. 6, 2010 The medical ... recognized by the U.S. Department of Health and Human ... therapeutic discovery."  The designation earns the company a grant ... Project designation and grant is provided for under the ...
Cached Biology Technology:Cephalon Announces Chairman and CEO to Remain on Medical Leave of Absence Indefinitely 2Early Safety Results Promising for Phase I/II Trial of Gene Therapy Treatment of Hemophilia B 2Early Safety Results Promising for Phase I/II Trial of Gene Therapy Treatment of Hemophilia B 3Early Safety Results Promising for Phase I/II Trial of Gene Therapy Treatment of Hemophilia B 4Integrated Medical Systems' Technology Recognized as Qualified Therapeutic Discovery 2
... polystyrene with frosted labeling surfaces, volume ... counting. 100% integrity tested. Linkage: This ... number, created to easily match Cornings ... yet, please order under the old ...
... CellBIND surface is produced by a ... more hydrophilic surface giving more consistent, ... and yields. CellBIND enhances cell attachment ... reduced serum or serum-free medium. • ...
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
... 100-240 V, uses multiplex suspension array technology ... up to 100 proteins and peptides in ... is composed of up to 100 color-coded ... conjugated with a unique reactant specific to ...
Biology Products: