( t we could attack but maybe if we unde...)Attacking cancer's sweet tooth is effective strategy against tumors

t we could attack but maybe, if we understand exactly all the steps involved, we could devise alternative strategies to attack the same pathway," Fantin said. What makes the prospect of anti-glycolytic therapies even more attractive is their potential safety. Healthy cells meet 90 percent of their energy needs through OXPHOS. People who lack the LDHA enzyme appear to function normally though they cannot be pushed toward anaerobic exercise. "They have muscle destruction because they lack an alternative route for producing energy," Fantin said. It is not clear whether they have a lower indidence of cancer.

Also appealing is the idea of combining anti-glycolytic therapies with anti-angiogenic ones.

"If you have a molecule that is very stable you could think about delivering it first, obliterating the glycolytic pathway," said Fantin. Angiogenesis inhibitors would wipe out blood vessels and the oxygen supply with it, leaving the cells with no way to cope. "There is definite potential to combining these things," she said.

'"/>

Source:Harvard Medical School


Page: 1 2 3
Related biology news :

1. New understanding of cell movement may yield ways to brake cancers spread
2. Catching cancers spread by watching hemoglobin
3. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
4. Bitter or sweet? The same taste bud can tell the difference
5. UW-Madison scientists zero in on drugs sweet spots
6. Sweet water taste paradoxically predicts sweet taste inhibitors
7. Scientists seek to unwrap the sweet mystery of the sugar coat on bacteria
8. Healing honey: The sweet evidence revealed
9. A sweet solution for Alzheimers disease?
10. Uncovering DNAs sweet secret
11. A sweet step toward new cancer therapies