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Attacking cancer's sweet tooth is effective strategy against tumors

t we could attack but maybe, if we understand exactly all the steps involved, we could devise alternative strategies to attack the same pathway," Fantin said. What makes the prospect of anti-glycolytic therapies even more attractive is their potential safety. Healthy cells meet 90 percent of their energy needs through OXPHOS. People who lack the LDHA enzyme appear to function normally though they cannot be pushed toward anaerobic exercise. "They have muscle destruction because they lack an alternative route for producing energy," Fantin said. It is not clear whether they have a lower indidence of cancer.

Also appealing is the idea of combining anti-glycolytic therapies with anti-angiogenic ones.

"If you have a molecule that is very stable you could think about delivering it first, obliterating the glycolytic pathway," said Fantin. Angiogenesis inhibitors would wipe out blood vessels and the oxygen supply with it, leaving the cells with no way to cope. "There is definite potential to combining these things," she said.


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Source:Harvard Medical School


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