Navigation Links
Attacking cancer's sweet tooth is effective strategy against tumors

An ancient avenue for producing cellular energy, the glycolytic pathway, could provide a surprisingly rich target for anti-cancer therapies.

A team of Harvard Medical School (HMS) researchers knocked down one of the pathway's enzymes, LDHA, in a variety of fast-growing breast cancer cells, effectively shutting down glycolysis, and implanted the cells in mice. Control animals carrying tumor cells with an intact glycolytic pathway did not survive beyond 10 weeks. In striking contrast, only two of the LDHA-deficient mice died, one at 16 weeks, another at just over 18 weeks. Eighty percent of the mice outlived the four month experiment. The findings by Valeria Fantin, Julie St-Pierre, and Philip Leder appear in the June Cancer Cell.

"This is an exciting contribution that reveals a surprising Achilles heel in cancer cells. It also adds to our sense of opportunity for new avenues of cancer therapeutics," said Stuart Schrieber, Morris Loeb professor and chair of the Department of Chemistry and Chemical Biology at Harvard University.

As a tumor grows, cells crowd one another and may be cut off from oxygen-carrying blood vessels--a distinct disadvantage since most cells require oxygen to produce the bulk of their energy-storing adenosine triphosphate (ATP). In the 1920s, Otto Warburg proposed that some cancer cells evolved the ability to switch over to an ancient, oxygen-free route, the glycolytic pathway. What is more, they continue to use this pathway even when access to oxygen is restored. Though the so-called Warburg effect has since been confirmed, the role played by glycolysis in cancer has been largely ignored. Few have attempted to attack specific points along the glycolytic pathway to gain a therapeutic effect.

"LDHA could be one weak point that we could attack but maybe, if we understand exactly all the steps involved, we could devise alternative strategies to attack the same pathway," said Fantin, who was an HMS research fellow in
'"/>

Source:Harvard Medical School


Page: 1 2 3

Related biology news :

1. New understanding of cell movement may yield ways to brake cancers spread
2. Catching cancers spread by watching hemoglobin
3. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
4. Bitter or sweet? The same taste bud can tell the difference
5. UW-Madison scientists zero in on drugs sweet spots
6. Sweet water taste paradoxically predicts sweet taste inhibitors
7. Scientists seek to unwrap the sweet mystery of the sugar coat on bacteria
8. Healing honey: The sweet evidence revealed
9. A sweet solution for Alzheimers disease?
10. Uncovering DNAs sweet secret
11. A sweet step toward new cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Attacking cancer sweet tooth effective strategy against tumors

(Date:7/24/2014)... (July 24, 2014) Scientists at The New ... one step closer to creating a viable cell ... own cells. , For the first time, ... lines from skin samples of patients with primary ... accelerated protocol to induce these stem cells into ...
(Date:7/24/2014)... by 45% on average over a 35 year period ... on the impact of humans on declining animal numbers. ... such as insects, spiders, crustaceans, slugs and worms bring ... for crops, decomposition for nutrient cycling, water filtration and ... and led by UCL, Stanford and UCSB, focused ...
(Date:7/24/2014)... identified two factors that characterize sustainable university and ... highly qualified physics teachers. Specifically, one or more ... education in combination with institutional motivation and commitment ... Technology, Engineering and Math (STEM) teacher shortages are ... the way for institutions seeking to increase the ...
Breaking Biology News(10 mins):NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Creating sustainable STEM teacher preparation programs 2
... Genetics has provided surprising insights into why vaccines ... serious childhood infections can eventually fail. The study, published ... bacteria change their disguise to evade the vaccines, has ... effective. Pneumococcus ( Streptococcus pneumoniae ) causes potentially ...
... Climate Change today finds that tropical vegetation contains 21 ... combination of remote sensing and field data, scientists from Woods ... Maryland were able to produce the first "wall-to-wall" map (with ... carbon storage of forests, shrublands, and savannas in the tropics ...
... aspect of light that humans are essentially blind to: polarized ... reef dwelling animals are but this has not always been ... Thanks to generous support provided by a Yulgilbar Foundation Fellowship, ... Ecology of Vision Laboratory in Bristol,s School of Biological Sciences, ...
Cached Biology News:Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines 2Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines 3The good news about carbon storage in tropical vegetation 2The good news about carbon storage in tropical vegetation 3Capturing an octopus-eye view of the Great Barrier Reef 2
(Date:7/24/2014)... Gain recognition for leadership and ... the biotech industry. Nominations are now being accepted ... you by the Bio Supply Management Alliance ... management professionals for the past 7 years. , ... Biotech industry – Manufacturers, Service Providers, Material Suppliers, ...
(Date:7/24/2014)... leader Yung-Eun Sung has announced that they have ... graphenes which can be applied as high performance ... Sung is both a group leader at the ... Science* (IBS) and a professor at the Seoul ... with regards to the development of relative simplicity, ...
(Date:7/24/2014)... DUBLIN , July 24, 2014 ... the "Global Genomics and Proteomics Analytical Instruments Market ... http://photos.prnewswire.com/prnh/20130307/600769 Genomics is the ... is the study of the structure and functions of ... and bioinformatics tools and technology. Genomics involves the mapping ...
(Date:7/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Sulphate basic information, including its definition, classification, ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis, ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... To mark 50 years of,service to the Parkinson,s ... authoritative round-up of the state of Parkinson,s,research at ... Friday, October,12. The jam-packed program will feature 43 ... science and quality,of life initiatives., The meeting, ...
... a privately,held biotechnology company focused on developing novel ... appointed William,T. Poncy, M.B.A., as vice president of ... of Ketasyn (AC-1202) as a medical food,product in ... "Given his strong track record in all ...
... AUSTIN, Texas, Oct. 10 Luminex Corporation,(Nasdaq: LMNX ... quarter,results on Wednesday, October 24, 2007. Results are scheduled ... hold a conference call to discuss the operating,highlights and ... on October 25, 2007, at 8:00 a.m. Eastern time. ...
Cached Biology Technology:The Parkinson's Disease Foundation Commemorates its 50th Anniversary with Special Scientific Symposium on Parkinson's Disease 2The Parkinson's Disease Foundation Commemorates its 50th Anniversary with Special Scientific Symposium on Parkinson's Disease 3Accera, Inc. Names William T. Poncy Vice President of Commercial Development 2Accera, Inc. Names William T. Poncy Vice President of Commercial Development 3Luminex Corporation Third Quarter Earnings Release Scheduled for October 24, 2007 2Luminex Corporation Third Quarter Earnings Release Scheduled for October 24, 2007 3
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
... Kit is designed to purify double-stranded DNA (dsDNA) ... and PCR. The process is simple and fast. ... g can be efficiently purified and concentrated. The ... is bound to the Microfilter Cartridge in the ...
Normal donkey serum collected from healthy normal donkeys....
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Biology Products: