Navigation Links
Asthma gene clusters identified

Children who suffer from acute asthma attacks share a genetic profile that appears to be unique to these children, according to a new study by researchers at Cincinnati Children's Hospital Medical Center. The discovery opens the door to the possibility of designing treatments specifically tailored to children who suffer from the severest forms of asthma.

The findings appear in the Feb. 10 issue of the Journal of Allergy and Clinical Immunology.

The study is based on an Affymetrix "GeneChip" analysis of RNA isolated from the nasal epithelium of children who have an acute case of asthma or asthma stabilized with medication. The analysis revealed two distinct gene expression profiles in these groups of children, according to Gurjit K. Khurana Hershey, MD, PhD, director of the Center for Translational Research in Asthma and Allergy at Cincinnati Children's and senior author of the study.


"We found that children who were having an acute asthma attack had a gene expression profile that was clearly different from those seen in someone with stable (controlled) asthma. The amazing thing was that the gene expression profiles were consistent across patients, despite the likely differences with respect to the cause of asthma," she said.

Asthma is the most common chronic disease of childhood affecting 20 million Americans, according the Centers for Disease Control. Experts know that environmental factors can lead to asthmatic conditions in children, but they also know that genetics contributes to susceptibility. There are no cures for asthma, but it can be controlled with treatment.

To date, researchers have identified individual genes involved in asthma, but this is the first time that clusters of known genes have been identified as being activated in acute forms of childhood asthma.

Dr. Hershey said the findings open the door to the possibility of developing treatments based on the unique genetic profile of patients. For ex
'"/>

Source:Cincinnati Children's Hospital Medical Center


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation
3. Bacteria in Household Dust May Trigger Asthma Symptoms
4. How Dirt Could Educate The Immune System And Help Treat Asthma
5. Software agents could help unmask reality of disease clusters
6. Source of molecular triggers in cutaneous T cell lymphoma identified
7. Key molecule in plant photo-protection identified
8. Critical role in programmed cell death identified
9. Key mechanism in genetic inheritance during cell division identified
10. Two new retroviruses—transmitted from animals—identified
11. Molecular steps involved in the creation of gene-silencing microRNAs identified
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Asthma gene clusters identified

(Date:4/23/2014)... shows that male black widow spiders prefer their female ... of mate preference by male spiders. , ... Maydianne Andrade, a professor in UTSC,s Department of Biological ... wild that males overwhelmingly chose to mate with well-fed, ... tell whether a potential mate is well-fed and unmated ...
(Date:4/23/2014)... Scientists have conclusive evidence that the source of a ... Ocean and called the "bio-duck," is the Antarctic minke ... by submarine personnel in the 1960s who thought it ... recorded at various locations in the Southern Ocean, but ... In February 2013, an international team of researchers deployed ...
(Date:4/23/2014)... group decision increases with the abundance of brains involved ... variety of factors as often happens in life ... groups actually tend to make more accurate decisions while ... pieces of information. , The findings present a significant ... the "wisdom of crowds," wherein individual observations even ...
Breaking Biology News(10 mins):Picky male black widow spiders prefer well-fed virgins 2Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... herders are facing the challenges of adapting to climate ... for herds to find food and navigate. To help ... them with satellite-based snow maps. "Snow is of ... whether reindeer are able to access the pastures that ...
... ANN ARBOR, Mich. Head and neck cancer patients who ... they were diagnosed had worse survival outcomes than those with ... University of Michigan Comprehensive Cancer Center. "While there has ... be linked to cancer survival, the health habits a person ...
... report finds that man-made toxic chemicals used as flame retardants in consumer products are found in all US coastal ... Click here for more information. , ... , , , ... , , , , ...
Cached Biology News:Satellite snow maps help reindeer herders adapt to a changing Arctic 2Health choices predict cancer survival, U-M study finds 2NOAA report calls flame retardants concern to US coastal ecosystems 2NOAA report calls flame retardants concern to US coastal ecosystems 3NOAA report calls flame retardants concern to US coastal ecosystems 4
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... investment in science and technology, as well expand ... third Office of Naval Research (ONR)-sponsored International Lecture ... headquarters. "The Arrival of Brazil" lecture featured ... Warfare Center, Carderock; Dr. Eugenius Kaszkurewicz, director of ...
... Oct. 22 Shrink Nanotechnologies, Inc. ("Shrink") (OTC ... nanotechnology company developing products and licensing opportunities in ... and biotechnology research and development tools businesses, announced ... to produce a high content screening tool for ...
... Encorium Group, Inc. (Nasdaq:  ENCO), (the "Company"), ... conducting studies in over 30 countries for many ... today announced that, on October 20, 2010, it ... (the "Panel") has determined to delist the Company,s ...
Cached Biology Technology:ONR lecture focuses on Brazil's growth in global science and technology 2Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 2Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 3Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 4Shrink Nanotechnologies Enters Into Agreement to Produce High Content Screening Software Called 'Stemage' for its StemDisc Stem Cell Culturing Products 5Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 2Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 3Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 4
Features , Designed to assist users in applying domed caps to tube strips and plates , Minimises the pressure required to seal the caps effectively , Enables multiple tubes to be sealed simultaneousl...
Request Info...
Sterile, individually wrapped, 4mm Cuvettes...
versican (H-56)...
Biology Products: