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Association of herpesvirus with lung disorder questioned

nrelated patients.

Like the authors of the earlier study, Katano and colleagues performed two types of tests in the tissue samples, one to detect an antigen associated with HHV-8, the other to detect HHV-8 DNA. Both tests failed to detect either the antigen or the DNA in any of the 22 samples from the two groups with some form of pulmonary hypertension, whereas the antigen was detected in the control group of Kaposi's sarcoma tissue samples.

These data suggest that human herpesvirus 8 infection is not associated with Japanese cases of primary pulmonary hypertension, the investigators concluded. In contrast, the 2003 study identified evidence of HHV-8 in ten of 16 samples from U.S. patients with primary pulmonary hypertension.

The researchers noted that while their results call the earlier study results into question, there are other possible explanations for the divergent data. For example, the pathogenesis of primary pulmonary hypertension in Japan may be different from that in the United States. The sensitivity and methods of the tests used in each study may also have differed.

"We hope that our results provide scientists with another perspective on the potential causes of primary pulmonary hypertension," Dr. Katano said. "Further studies are required to clarify the possible association of human herpesvirus 8 with this disease."


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Source:Eurekalert


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