Navigation Links
Aspirin reduces cardiovascular risks in men and women -- but differently

Aspirin can significantly reduce the risk of cardiovascular events -- a combined endpoint including stroke, heart attack and death due to cardiovascular disease -- in both men and women, according to a new meta-analysis of more than 95,000 patients by a Duke University Medical Center cardiologist.

However, the researchers found, the major reasons for the risk reduction differed between the sexes. For men, aspirin lowered the risk of a heart attack, while in women, aspirin reduced the risk of a stroke.

The use of aspirin, however, also carries an increased risk of bleeding among both sexes, the study found. The results of the new analysis lead the researchers to recommend that all patients and physicians should discuss the benefits and drawbacks of regularly taking aspirin as a preventative measure against cardiovascular events.

"Aspirin is a drug that has been used for many years ?it is well-understood, effective, inexpensive and widely available," said Duke cardiology fellow Jeffrey Berger, M.D, first author of a paper published Jan. 18, 2006, in the Journal of the American Medical Association. He performed much of the research while at Beth Israel Medical Center, New York, under senior author cardiologist David Brown, M.D.

"This is good news because many of the past studies of the effect of aspirin in preventing cardiovascular events looked only at men, so physicians were reluctant to prescribe aspirin for women because there was little data," Berger continued. "But now, the combined data of recent trials involving women demonstrates that women can benefit just as much from aspirin therapy as men."

Berger emphasized that more healthy men and women who can tolerate aspirin should be taking the medication for the prevention of cardiovascular disease. It is estimated that fewer than five percent of the population suffers from the known gastrointestinal side effects of aspirin or are allergic to it, meaning that many more serious cardiovascular events could be prevented if aspirin was more widely used, Berger said

In his analysis, Berger combined the data from six different randomized clinical trials, which yielded a total of 95,456 patients, none of whom had coronary artery disease. Of that total, 51,342 were women. The trials all involved the comparison of low-dose aspirin versus placebo for the primary prevention of cardiovascular disease.

The analysis revealed that aspirin conferred a 12 percent reduction in risk in cardiovascular events for women, and a 14 percent reduction for men.

"Our findings are particularly noteworthy in that aspirin's main beneficial effects appeared to be the reduction in the risk of stroke for women and reduction in the risk of heart attacks for men," Berger said. "While our analysis showed that aspirin may have different effects in men and women, the relatively small number of heart attacks among women and strokes among men suggest that more research is needed to better understand any differences in cardiovascular responses to aspirin."

Specifically, among the 51,342 women in the analysis, there were 625 strokes and 469 heart attacks. Among the 44,114 men, there were 597 strokes and 1,023 heart attacks.

However, the routine use of aspirin does not come without potential risks, especially in terms of major bleeding episodes. The analysis found that routine aspirin use for an average of 6.4 years would lead to 2.5 major bleeding events per 1,000 women and 3 major bleeding events per 1,000 men.

"For this reason, while we believe that many more people could benefit from taking aspirin, it is important for patients and their physicians to discuss the issue and weigh the benefits and potential drawbacks to this therapy," Berger said. "Also, aspirin should never replace other ways of reducing cardiovascular risks, such eating a proper diet and exercising."

Of the six randomized clinical trials involved in the a nalysis, three enrolled solely men, one included only women, and two enrolled both sexes. The trials were: Physicians Health Study, British Doctor's Trial, Thrombosis Prevention Trial, Hypertension Optimal Treatment Trial, Primary Prevention Project and the Women's Health Study.


'"/>

Source:Duke University Medical Center


Related biology news :

1. Aspirin discovery may improve cancer treatments
2. Male circumcision reduces risk of HIV transmission from women to men
3. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
4. New miniaturised chip dramatically reduces time taken for DNA analysis
5. New processing method reduces peanut allergenicity
6. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
7. Study finds that nutritionally enhanced rice reduces iron deficiency
8. Overfishing in inland waters reduces biodiversity and threatens health
9. New gene reduces retinal degeneration in fruit flies
10. Prenatal nicotine exposure reduces breathing response of newborns...
11. Heat-shock protein vaccine reduces alveolar bone loss
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:5/24/2016)... May 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology ... LCD display is the latest premium product recently added to the range of products ... ... ... 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of ... their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been ... Target to its list of well-respected retailers. This list includes such fine stores ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
Breaking Biology Technology: