Navigation Links
Any exposure to tobacco smoke during pregnancy is risky

A re-examination of data from earlier studies suggests that exposure to second-hand smoke during pregnancy can be just as detrimental to a developing fetus as primary exposure through maternal smoking, according to a recent paper from the University of Pittsburgh Graduate School of Public Health.

In a study published in the online journal BMC Pediatrics, Stephen G. Grant, Ph.D., associate professor of environmental and occupational health, reports that both active maternal smoking and secondary maternal exposure result in similarly increased rates of genetic mutation that are basically indistinguishable.

"This analysis shows not only that smoking during pregnancy causes genetic damage in the developing fetus that can be detected at birth, but also that passive ?or secondary ?exposure causes just as much damage as active smoking, and it is the same kind of damage," said Dr. Grant, whose primary area of study is genotoxicity and the mechanisms of DNA repair. "These kinds of mutations are likely to have lifelong repercussions for the exposed fetus, affecting survival, birth weight and susceptibility to disease, including cancer."

This is a startlingly different conclusion than that reached by three previous studies looking at the potential effects of tobacco smoke exposure to babies in the womb, one of which Dr. Grant co-authored. The primary papers largely discounted the effects of secondary ?and sometimes even direct exposure through maternal smoking ?or produced contradictory results.

The original studies looked at mutation rates at the HPRT gene located on the X chromosome in cord blood samples from newborns. Dr. Grant's analysis pooled the studies' data, looking for frequency of induced mutation as well as the resulting molecular spectrum of mutations. In particular, the new analysis redefines the "non-smokers" used as controls to consider their second-hand exposure to tobacco smoke through other family members at home, at work or in social situations at restaurants or even outdoors.

"Moreover, we found similarly increased induced mutation in women who had quit smoking during pregnancy, usually when they found out they were pregnant," said Dr. Grant, who also is an assistant investigator at the Magee-Womens Research Institute. "Perhaps, like certain pharmaceutical warnings, it would be appropriate to caution women to quit smoking if they are pregnant or likely to become pregnant. It is equally imperative that workplace protection be offered to reduce passive exposure."


Source:University of Pittsburgh Medical Center

Related biology news :

1. Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers
2. Prenatal exposure to famine increases risk of schizophrenia
3. Prenatal exposure to marine toxin causes lasting damage
4. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
5. Prenatal nicotine exposure reduces breathing response of newborns...
6. Nicotine exposure during development leads to hearing problems
7. Bird brains shrink from exposure to contaminants
8. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
9. Solvent exposure linked to birth defects in babies of male painters
10. Early exposure to indoor fungus molecules may protect infants against future allergies
11. Scientists turn tobacco against cancer
Post Your Comments:

(Date:10/27/2015)... Munich, Germany , ... (ASGM) automatically maps data from mobile eye tracking videos ... so that they can be quantitatively analyzed with SMI,s ... Germany , October 28-29, 2015. SMI,s Automated Semantic ... eye tracking videos created with SMI,s Eye Tracking ...
(Date:10/26/2015)... Calif. and LAS VEGAS ... Nok Nok Labs , an innovator in modern authentication ... , today announced the launch of its latest version ... unified platform enabling organizations to use standards-based authentication that ... Nok Nok S3 Authentication Suite is ideal for organizations ...
(Date:10/23/2015)... and GOLETA, California , October ... conference, BIOPAC and SensoMotoric Instruments (SMI) announce a mobile ... tracking data captured during interactive real-world tasks ... play integration of their established wearable solutions for eye ... synchronize gaze behavior captured with SMI Eye Tracking ...
Breaking Biology News(10 mins):
(Date:11/26/2015)... , England , November 26, 2015 /PRNewswire/ ... Medical, an innovative medical device company specializing in imaging technologies, ... from the European Commission as part of the Horizon 2020 ... company to carry out a large-scale clinical trial in breast ...      (Logo: , --> ...
(Date:11/25/2015)... ANNAPOLIS, Md. , Nov. 25, 2015  PharmAthene, ... of Directors has adopted a stockholder rights plan (Rights ... its net operating loss carryforwards (NOLs) under Section 382 ... --> --> PharmAthene,s use of its ... an "ownership change" as defined in Section 382 of ...
(Date:11/25/2015)... November 25, 2015 Studies reveal ... human plaque and pave the way for more effective treatment ... cats     --> ... diagnosed health problems in cats, yet relatively little was understood ... collaborative studies have been conducted by researchers from the WALTHAM ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. ... Gorman , President and CEO of Neurocrine Biosciences, will ... Conference in New York . ... visit the website approximately 5 minutes prior to the ... replay of the presentation will be available on the ...
Breaking Biology Technology: