Navigation Links
Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

In people infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy (HAART) may prevent most excess cases of Kaposi sarcoma and non-Hodgkin lymphoma, according to a new study in the March 16 issue of the Journal of the National Cancer Institute.

Studies of people with acquired immunodeficiency syndrome (AIDS) have reported increased risks of several cancers, including Kaposi sarcoma, non-Hodgkin lymphoma, and, to a lesser extent, anal cancer, invasive cervical cancer, and Hodgkin lymphoma. However, less well understood are the associations of these cancer risks with the use of HAART, with immune status, and with behavioral risk factors such as smoking.

To estimate excess cancer risk in people infected with HIV and investigate the modifying effects of the use of HAART and behavioral factors on this cancer risk, Gary M. Clifford, Ph.D., of the International Agency for Research on Cancer in Lyon, France, and colleagues analyzed data from the Swiss HIV Cohort Study and Swiss cancer registries on more than 7,300 people infected with HIV.

People with HIV in the study had a highly elevated risk of Kaposi sarcoma and non-Hodgkin lymphoma. They also had an increased risk of anal cancer, Hodgkin lymphoma, cervical cancer, liver cancer, cancer of the lip, mouth, and pharynx, and non-melanoma skin cancer. People who used HAART had lower risks of Kaposi sarcoma and non-Hodgkin lymphoma compared with those who did not use HAART, although even with HAART these tumors occurred 20 times more frequently than they do in the general population without HIV/AIDS. HAART use was not associated with lower risks of Hodgkin lymphoma or other cancers. Although people infected with HIV had increased risks of cancers of the lung, lip, mouth, and pharynx, no cases of these cancers were found among nonsmokers.

"In conclusion, HAART treatment may prevent excess risk of [Kaposi sarcoma] and non-Hodgkin lymphoma, but not that of Hodgkin lymp homa or other non–AIDS-defining cancers," the authors write. "Focusing on ways to encourage persons infected with HIV to quit smoking would be effective in reducing lung cancer in these persons."

In an editorial, Eric A. Engels, M.D., and James J. Goedert, M.D., of the National Cancer Institute, revisit the history of the AIDS epidemic and how the knowledge of cancer and immune diseases has grown since it began. They note that questions remain about the types and severity of cancers that will appear in coming years among patients on HAART, who have less severe but prolonged immunosuppression. "Controlling the epidemic and ameliorating the suffering of persons living with HIV/AIDS are more urgent than ever," they write. "Continued study of cancer in people with HIV/AIDS will redound to give us clues about cancer etiology to the benefit of all."

Citations:
# Article: Clifford GM, Polesel J, Rickenbach M on behalf of the Swiss HIV Cohort Study, Dal Maso L, Keiser O, Kofler A, et al. Cancer Risk in the Swiss HIV Cohort Study: Associations With Immunodeficiency, Smoking, and Highly Active Antiretroviral Therapy. J Natl Cancer Inst 2005;97:425?2.

# Editorial: Engels EA, Goedert JJ. Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome and Cancer: Past, Present, and Future. J Natl Cancer Inst 2005;97:407?.


'"/>

Source:Journal of the National Cancer Institute


Related biology news :

1. Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants
2. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
3. Columbia research lifts major hurdle to gene therapy for cancer
4. Combination therapy boosts effectiveness of telomere-directed cancer cell death
5. Gene therapy converts dead bone graft to new, living tissue
6. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
9. New therapy for HIV/AIDS eliminates needles and excessive toxicity
10. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
11. Gene therapy for Parkinsons disease moves forward in animals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/10/2018)... ... 2018 , ... Today, RoosterBio Inc. and Tissue Regeneration Therapeutics ... the development of the Regenerative Medicine field. This alliance will be focused ... umbilical cord perivascular cells (HUCPVCs). Together, it is anticipated that these technology ...
(Date:12/5/2018)... ... December 03, 2018 , ... Quanta System announced today ... the distribution and marketing of cutting-edge aesthetic devices in the US. Since inception ... 2018. Cartessa’s success can be attributed in-part to the company’s independent business ...
(Date:12/5/2018)... ... 2018 , ... The new program allows 3rd ... innovative solutions for which high-speed imaging is a necessary albeit challenging component. , ... and instrumentation, allowing partner companies to dedicate their resources on their core strengths ...
Breaking Biology News(10 mins):
(Date:11/9/2018)... ... November 08, 2018 , ... IC System, ... machine-learning powered approach to increasing recovery rates by creating a comprehensive contact strategy ... (AIC) product developed by NLP Logix, a Jacksonville, Florida-based AI solutions company, and ...
(Date:11/6/2018)... ... November 06, 2018 , ... ... for clinical trial data collection and management. TrialKit ™, an eClinical platform, ... generation devices can quickly and easily sign in to the app via facial ...
(Date:11/5/2018)... Ill. (PRWEB) , ... November 05, 2018 , ... ... Inc., for access to 2Blades’ Transcription Activator Like (TAL) effector code technology for ... for commercial uses of the technology in plants. Since its discovery in 2009, the ...
(Date:10/31/2018)... ... 30, 2018 , ... Myoscience, Inc. announced today that it ... Memphis, Tennessee. This study enrolled 125 patients and compares the effect of ... after total knee replacement surgery (TKA). , The Myoscience iovera° system is currently ...
Breaking Biology Technology: