Navigation Links
Antioxidant protects against lung damage in silicosis

Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.

These results appear in the second issue for October 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Yoshiaki Ishigatsubo, M.D., Ph.D., of the Department of Internal Medicine and Clinical Immunology at Yokohama City University in Japan, and 11 associates studied 46 male patients with silicosis, an inflammatory disorder caused by inhaling crystalline silica for prolonged periods. The study included 27 male patients with chronic obstructive pulmonary disease and 27 healthy male volunteers as controls. The investigators also studied a mouse model of silicosis.

Silicosis results from exposure to crystalline silica in mines and foundries, at sand blasting operations and at stone, clay, and glass manufacturing plants. Crystalline silica induces the production of reactive oxygen species, which can cause scar tissue to develop in the lungs.

About 1 million workers are believed to have been exposed to silica dust in the U.S. More than 10,000 silicosis patients are currently being followed in Japan.

"Pulmonary HO-1 expression is increased in silicosis," said Dr. Ishigatsubo. "HO-1 suppresses reactive oxygen species activity, and its subsequent pathologic changes, thereby reducing disease progression."

The researchers noted that their work was the first to demonstrate that HO-1 is synthesized in the lungs of patients with silicosis, thus contributing to a significant elevation of serum HO-1 levels in these patients.

"Silica particles were consistently associated with lesions containing HO-1 expressing cells," added Dr. Ishigatsubo. "The number of HO-1-expressing cells w
'"/>

Source:American Thoracic Society


Page: 1 2

Related biology news :

1. Antioxidant selenium offers no heart-disease protection
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Experiments provide proof of how traveling in groups protects insects
4. Experiments provide proof of how traveling in groups protects insects
5. Substance protects resilient staph bacteria
6. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
7. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
8. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
9. Excess liver gene protects against high-fat diet
10. New vaccine protects more effectively against tuberculosis
11. New type of rejection blocker protects kidneys after transplant
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Antioxidant protects against lung damage silicosis

(Date:7/31/2014)... make a rational choice to be liberal or conservative? ... a matter of genetics?, Two political scientists from the ... say that neither conscious decision-making nor parental upbringing fully ... right. , A growing body of evidence shows that ... of political differences, the researchers say in the latest ...
(Date:7/31/2014)... In the same week that the U.S. surgeon general ... cancer, researchers at Montana State University published a paper ... code in every cell responds when exposed to ... of DNA damage by the UV rays found in ... and some degenerative eye diseases. , "Our paper ...
(Date:7/31/2014)... found that bacteria in the Gulf of Mexico consumed ... during the Deepwater Horizon spill in the months after ... In two new studies conducted in a deep sea ... bacteria called Colwellia likely consumed gaseous hydrocarbons ... were released as part of the oil spill. ...
Breaking Biology News(10 mins):Scientists find growing consensus: Political attitudes derive from body and mind 2New paper describes how DNA avoids damage from UV light 2New paper describes how DNA avoids damage from UV light 3
... human activity and the extinction of species around the ... a Canadian zoologist. This ecological damage also endangers human ... Dr. Daniel (Dan) Brooks, a parasitologist at the University ... linked to the emergence of new human and wildlife ...
... doing or reading a paper about microarray-based experiments,reproductibility, especially ... If I redo the same experiment in one month, ... demonstrated that microarrays experiments performed in different labs ... , as long as standardized protocols are carefully followed". ...
... study to examine the probability of,HIV infection per act ... has found that uncircumcised men have more,than twice the ... study, published in the Feb. 15 issue of The ... colleagues,from the United States and Kenya collected detailed sexual ...
Cached Biology News:Ecological destruction fuels emerging diseases 2Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible 2Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible 3Male circumcision reduces risk of HIV transmission from women to men 2
(Date:7/31/2014)... SHENZHEN, China , July 31, 2014 /PRNewswire/ ... of an Irys™System by BGI , ... to enable comprehensive exploration of human structural variation (SV) ... of interest, including those where no reference exists. In ... new methods for multiplexing on the Irys System, enabling ...
(Date:7/31/2014)... July 31, 2014 “Rapid technological ... across the U.S., increasing unemployment, depressing American consumer ... It is a Catch 22—we need automated manufacturing ... means fewer jobs,” says economist and corporate relocation ... Corporate Top 10 Pro-Business States for 2014, co-published ...
(Date:7/31/2014)... 31, 2014 Sales Horizons, a leader ... online sales training course – Mastering the Complex ... performance. , Drawn from proven sales training programs used ... the Complex Sale online sales training course is available ... has face-to-face contact with customers, like technical support, engineers, ...
(Date:7/30/2014)... 30, 2014 A study presented at ... and efficacy of CSL Behring,s C1 Inhibitor (C1-INH) ... in highly sensitized patients. C1-INH is a human ... system. The study shows that post-transplant ... the levels of complement components 3 and 4, ...
Breaking Biology Technology:BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3
... Catapult Systems , a leading Microsoft IT ... Microsoft SharePoint 2010 and FAST implementation for Array BioPharma, ... commercialization of targeted small molecule drugs to treat patients ... Earlier this year, Array conducted a proof of concept ...
... Inc. (OTC Bulletin Board: WDST ) a biotechnology ... restore the health of damaged tissues and organs, today announced ... viewing. LINK: www.retailinvestorconferences.com ... 90 days. Investors may download shareholder materials from the "virtual ...
... Halozyme Therapeutics, Inc. (Nasdaq: HALO ... targeting the extracellular matrix for the ... reported financial results for the third quarter ended ... http://photos.prnewswire.com/prnh/20100302/LA63139LOGO ) (Logo: http://www.newscom.com/cgi-bin/prnh/20100302/LA63139LOGO ) ...
Cached Biology Technology:Catapult Systems Awarded SharePoint 2010 and FAST Intranet Project 2Catapult Systems Awarded SharePoint 2010 and FAST Intranet Project 3Regenicin Presentation Now Available Online at RetailInvestorConferences.com 2Halozyme Therapeutics Reports Third Quarter 2010 Financial Results 2Halozyme Therapeutics Reports Third Quarter 2010 Financial Results 3Halozyme Therapeutics Reports Third Quarter 2010 Financial Results 4Halozyme Therapeutics Reports Third Quarter 2010 Financial Results 5Halozyme Therapeutics Reports Third Quarter 2010 Financial Results 6Halozyme Therapeutics Reports Third Quarter 2010 Financial Results 7
... Leukemia Virus Reverse Transcriptase (M-MLV RT) is an ... cDNA synthesis with long messenger RNA templates (>5kb). ... gene of M-MLV and consists of a single ... RNase H activity of M-MLV RT is weaker ...
... the determination of digitonin and digoxin. Physical form: ... 4 and 0.06% NaCl Preparation Note: Sodium ... Biophys. Res. Commun., 19, 755 (1965). Unit ... inorganic phosphorus from ATP per min at pH ...
kismet (dK-20)...
... Thermo Hybaid's unique Electro-4 design allows "4 ... Electro-4 it is possible to run 200,samples ... by stacking up to four,horizontal gels. To ... according to the number of gels being ...
Biology Products: