Navigation Links
Antioxidant protects against lung damage in silicosis

Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.

These results appear in the second issue for October 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Yoshiaki Ishigatsubo, M.D., Ph.D., of the Department of Internal Medicine and Clinical Immunology at Yokohama City University in Japan, and 11 associates studied 46 male patients with silicosis, an inflammatory disorder caused by inhaling crystalline silica for prolonged periods. The study included 27 male patients with chronic obstructive pulmonary disease and 27 healthy male volunteers as controls. The investigators also studied a mouse model of silicosis.

Silicosis results from exposure to crystalline silica in mines and foundries, at sand blasting operations and at stone, clay, and glass manufacturing plants. Crystalline silica induces the production of reactive oxygen species, which can cause scar tissue to develop in the lungs.

About 1 million workers are believed to have been exposed to silica dust in the U.S. More than 10,000 silicosis patients are currently being followed in Japan.

"Pulmonary HO-1 expression is increased in silicosis," said Dr. Ishigatsubo. "HO-1 suppresses reactive oxygen species activity, and its subsequent pathologic changes, thereby reducing disease progression."

The researchers noted that their work was the first to demonstrate that HO-1 is synthesized in the lungs of patients with silicosis, thus contributing to a significant elevation of serum HO-1 levels in these patients.

"Silica particles were consistently associated with lesions containing HO-1 expressing cells," added Dr. Ishigatsubo. "The number of HO-1-expressing cells w as significantly higher in patients with silicosis than in control subjects."

The investigators said that their present results indicate that silicosis patients' serum HO-1 levels correlate significantly with their primary lung function test level and vital capacity. (Vital capacity is the maximum amount of air that can be exhaled after a maximum inhalation, showing the status of lung tissue.)

The authors believe that if serum HO-1 derives primarily from lung lesions, it could also represent a novel biomarker for evaluating the severity of silicosis.

In their mouse studies, hemin, a potent inducer of HO-1, suppressed acute inflammation after silica exposure, whereas zinc protoporphyrin, an inhibitor of HO-1, accelerated the development of silicosis lesions.
'"/>

Source:American Thoracic Society


Related biology news :

1. Antioxidant selenium offers no heart-disease protection
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Experiments provide proof of how traveling in groups protects insects
4. Experiments provide proof of how traveling in groups protects insects
5. Substance protects resilient staph bacteria
6. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
7. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
8. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
9. Excess liver gene protects against high-fat diet
10. New vaccine protects more effectively against tuberculosis
11. New type of rejection blocker protects kidneys after transplant

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... Dr. Greg Leyer, Chief Scientific ... on September 27th. His presentation is at 12:10pm in the Probiotics Resource Center, Mandalay ... at SupplySide West and discuss how probiotics have shown impressive data in areas outside ...
(Date:9/21/2017)... ... September 21, 2017 , ... Today, BioPharma ... has announced the addition of 5 new courses to its prospectus. These include ... Regulation 21 CFR Part 11 on Electronic Records and Electronic Signatures (Part 11 ...
(Date:9/20/2017)... ... ... The award-winning producers behind the American Farmer series proudly ... at helping farmers solve the problem of nitrogen loss. The upcoming episode is ... RFD-TV. Check your local listings for more info. , As a global ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... Huron Digital Pathology , a provider of whole slide imaging solutions, are hosting ... . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy for Digital Pathology,” will ...
Breaking Biology Technology: