Navigation Links
Antioxidant protects against lung damage in silicosis

Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.

These results appear in the second issue for October 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Yoshiaki Ishigatsubo, M.D., Ph.D., of the Department of Internal Medicine and Clinical Immunology at Yokohama City University in Japan, and 11 associates studied 46 male patients with silicosis, an inflammatory disorder caused by inhaling crystalline silica for prolonged periods. The study included 27 male patients with chronic obstructive pulmonary disease and 27 healthy male volunteers as controls. The investigators also studied a mouse model of silicosis.

Silicosis results from exposure to crystalline silica in mines and foundries, at sand blasting operations and at stone, clay, and glass manufacturing plants. Crystalline silica induces the production of reactive oxygen species, which can cause scar tissue to develop in the lungs.

About 1 million workers are believed to have been exposed to silica dust in the U.S. More than 10,000 silicosis patients are currently being followed in Japan.

"Pulmonary HO-1 expression is increased in silicosis," said Dr. Ishigatsubo. "HO-1 suppresses reactive oxygen species activity, and its subsequent pathologic changes, thereby reducing disease progression."

The researchers noted that their work was the first to demonstrate that HO-1 is synthesized in the lungs of patients with silicosis, thus contributing to a significant elevation of serum HO-1 levels in these patients.

"Silica particles were consistently associated with lesions containing HO-1 expressing cells," added Dr. Ishigatsubo. "The number of HO-1-expressing cells w
'"/>

Source:American Thoracic Society


Page: 1 2

Related biology news :

1. Antioxidant selenium offers no heart-disease protection
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Experiments provide proof of how traveling in groups protects insects
4. Experiments provide proof of how traveling in groups protects insects
5. Substance protects resilient staph bacteria
6. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
7. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
8. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
9. Excess liver gene protects against high-fat diet
10. New vaccine protects more effectively against tuberculosis
11. New type of rejection blocker protects kidneys after transplant
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Antioxidant protects against lung damage silicosis

(Date:9/11/2014)... from the Rice Research Institute of Iran have ... from Europe and Asia, has changed its host preferences in ... importance of this adaptation for biological control of problematic weeds ... new host plant have been described in the open access ... of G. permixtana have been so far ...
(Date:9/11/2014)... of beetles in the genus Calathus , 17 of ... Ethiopian Highlands. Now scientists have found two new ones ... and have described them in Annals of the Entomological ... named for Juan Novoa, the son of one of the ... Adults are black and shiny, and are 9.5-11.5 millimeters long. ...
(Date:9/11/2014)... world and a concomitant upgrade of health care systems, ... a consequence, worldwide demand for agricultural products is also ... other important resources for seven billion humans. , ... wheat, maize, rice and vegetables. But as the ... to decline, the future ability to meet the world,s ...
Breaking Biology News(10 mins):Unusual host preference of a moth species could be useful for biological control 2Crop improvement and resistance to pathogens benefits from non-coding RNA studies 2Crop improvement and resistance to pathogens benefits from non-coding RNA studies 3
... A new study conducted in Bangladesh finds that ... levels in individuals chronically exposed to arsenic-contaminated drinking ... is naturally present in some soils and water. ... public health problem in at least 70 countries, ...
... projected increases in the use of corn for ethanol ... considerable, and water supply problems at the regional and ... from the National Research Council. The committee that ... for new agricultural techniques and technologies to help minimize ...
... study by Kevin Pope of Geo Eco Arc Research ... into the migration of anatomically modern humans out of ... present (BP). The comprehensive review of human ... supports the hypothesis, originally based largely on genetic evidence, ...
Cached Biology News:Folic acid lowers blood arsenic levels in Bangladesh 2Folic acid lowers blood arsenic levels in Bangladesh 3Increase in ethanol production from corn could significantly impact 2Increase in ethanol production from corn could significantly impact 3Environmental setting of human migrations in the circum-Pacific Region 2
(Date:9/11/2014)... a one atom thick sheet of carbon, can be ... form of graphene that could have a significant impact ... paint, it could provide an ultra-strong, non-corrosive coating for ... oxide solutions can be used to paint various surfaces ... After a simple chemical treatment, the resulting coatings behave ...
(Date:9/11/2014)... PA (PRWEB) September 11, 2014 ... conferee registration is now open for Pittcon ... for laboratory science. The event will be held ... Center, New Orleans, Louisiana. , The discounted ... 20, 2015. ($350 after 2/20/2015). This affordable price ...
(Date:9/11/2014)... - Portage Biotech Inc. ("Portage" or "the Company") (OTC: ... intends to conduct a Private Placement to raise ... preclinical development activities and financial commitments to Biohaven ... Company is proposing to complete a non-brokered offering ... a price of US$0.10 per Share, for gross ...
(Date:9/11/2014)... Awarded annually by Germany’s Design Zentrum Nordrhein-Westfalen, the ... label for excellent design. METTLER TOLEDO is extremely ... Dot award in recognition of high design ... , The Quantos Handheld Powder Dispenser (HPD) ... applications involving free-flowing powders. Forget the delicacy and ...
Breaking Biology Technology:Graphene paints a corrosion-free future 2Conferee Registration Opens for Pittcon 2015; Housing & Travel Open for Reservations 2Portage Announces Proposed Private Placement 2Portage Announces Proposed Private Placement 3Portage Announces Proposed Private Placement 4METTLER TOLEDO Handheld Powder Receives Red Dot Award for Product Design 2
... ... ... var shortURL ... we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
... ... ... var shortURL = ""; BitlyCB.alertResponse ... grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for (var key in ...
... in a row, a pair of Rensselaer students took ... held by the American Society of Mechanical Engineers (ASME). ... Jaron Kuppers won top honors in the national competition ... process. The SET process offers a new method for ...
Cached Biology Technology:YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 2YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 3YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 4YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 5YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 6YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 7YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 8YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387 9Medivir: R&D Day 2Medivir: R&D Day 3Medivir: R&D Day 4Medivir: R&D Day 5Medivir: R&D Day 6Medivir: R&D Day 7Medivir: R&D Day 8Rensselaer mechanical engineers win first place at ASME student manufacturing design competition 2Rensselaer mechanical engineers win first place at ASME student manufacturing design competition 3Rensselaer mechanical engineers win first place at ASME student manufacturing design competition 4
...
... Lyophilized. Lyophilized from 2 mM sodium ... human liver. Cathepsin D is a major ... as a 52 kDa proenzyme. Overexpression of ... associated with higher risk of relapse and ...
... Grade Thrombin is a highly purified preparation ... with appropriate vectors. The preparation is functionally ... is free of detectable contaminating proteases. Prepared ... by certified tests to be negative for ...
Rat Hepatocytes (RH) (>3,000,000 cells)...
Biology Products: