Navigation Links
Antibody therapy prevents type 1 diabetes in mice

University of Pittsburgh investigators have successfully prevented the onset of type 1 diabetes in mice prone to developing the disease using an antibody against a receptor on the surface of immune T-cells. According to the investigators, these findings, which are being published in the January issue of the journal Diabetes, have significant implications for the prevention of type 1 diabetes.

More than 700,000 Americans have type 1 diabetes, an autoimmune disorder in which the body errantly attacks the insulin-producing cells of the pancreas, causing chronically elevated levels of sugar in the blood, leading to blindness, kidney failure, heart disease and nerve damage. Previously known as juvenile diabetes, type 1 diabetes is usually diagnosed at a very early age, but in some cases it can be diagnosed in adulthood.

In this study, the Pitt researchers treated non-obese diabetic (NOD) mice with an antibody -- a type of protein produced by the immune system that recognizes and helps fight infections and other foreign substances in the body -- directed against a receptor known as CD137 on the surface of a type of immune cell called T-cells. Treating NOD mice with the anti-CD137 antibodies significantly suppressed the development of diabetes, whereas most of the control mice developed diabetes by the time they were six months old.

Interestingly, the antibody therapy did not appear to cure the NOD mice because the researchers were still able to see lymphocytes in their pancreatic islets, a tell-tale sign of pancreatic inflammation and autoimmunity. In addition, when the researchers isolated cells from the spleens of the antibody-treated mice and injected these cells into immune-deficient NOD mice, seven of the nine recipient mice developed type 1 diabetes, indicating that the donor mice still harbored pathogenic T-cells. On the other hand, when the researchers transferred a certain subset of T-cells from anti-CD137-treated mice that expressed t wo other receptors known as CD4 and CD25 to other immune-deficient NOD mice, it prevented the onset of diabetes in the recipient mice.

According to senior author William M. Ridgway, M.D., assistant professor in the University of Pittsburgh School of Medicine's department of rheumatology and clinical immunology, this therapy, if given early enough, may offer a viable method for preventing the onset of type 1 diabetes in genetically at-risk people.

"Our studies and others suggest that CD137 plays a significant role in the development of and genetic predisposition to type 1 diabetes. In this study, for the first time, we have demonstrated that CD137 antibody therapy can suppress the development of type 1 diabetes in mice and that the effect is dependent on the induction of a certain subset of regulatory T-cells. If we can demonstrate this same genetic predisposition and therapeutic effect in human type 1 diabetes patients, then this may prove to be a significant step toward preventing this disease before it can take hold," he explained.


'"/>

Source:University of Pittsburgh Medical Center


Related biology news :

1. Antibody extends life of mice with breast cancer
2. Antibody signal may redirect inflammation to fuel cancer
3. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Gene therapy converts dead bone graft to new, living tissue
7. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
10. New therapy for HIV/AIDS eliminates needles and excessive toxicity
11. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/31/2017)...  Spero Therapeutics, LLC, a biopharmaceutical company founded ... bacterial infections, today announced it has acquired a ... Bono Bio Ltd (PBB) to bolster its pipeline ... of Gram-negative bacteria.   The assets acquired have been ... group company. "The acquisition of these ...
(Date:1/25/2017)... , Jan. 25, 2017 The Elements of ... (IAM) lifecycle is comprised of a comprehensive set ... purpose of maintaining digital identities and providing a ... applications. There are significant number of programs opted ... to time by optimizing processes and changing policies. ...
(Date:1/21/2017)... , Jan 20, 2017 Research and Markets ... Market 2017-2021" report to their offering. ... The global voice recognition biometrics market ... The report covers the present scenario and the ... To calculate the market size, the report considers the revenue generated ...
Breaking Biology News(10 mins):
(Date:2/28/2017)... ... February 28, 2017 , ... ... antibody therapeutics from millions-diverse immune repertoires, today announced a strategic partnership with ... genetically engineered to express human antibodies. The partnership will use GigaGen technology to ...
(Date:2/28/2017)... 2017  ITL Limited ( ASX:ITD ), an ... partner that provides innovative products and solutions to ... announces its rebrand to ITL Health Group (ITL). ... of the Company,s unified global rebranding plan and ... corporate website, ITLHealthGroup.com . ITL,s new brand ...
(Date:2/28/2017)... and NEW YORK , February 28, ... Application accepted by the FDA for avelumab  Prognosis ... has metastasized   EMD ... Germany , in the US and Canada ... Food and Drug Administration (FDA) has accepted for Priority Review ...
(Date:2/27/2017)... A Europe-wide survey of institutes conducted by the Basel Declaration ... treat them with due care. The survey polled a total of ... indicates that there is a strong commitment among animal researchers across ... of the 3Rs (Refine, Reduce, Replace)  ... What are the 3Rs? Refine: ...
Breaking Biology Technology: