Navigation Links
Antibody extends life of mice with breast cancer

A monoclonal antibody developed by researchers at the University at Buffalo has been shown to extend significantly the survival of mice with human breast-cancer tumors and to inhibit the cancer's spread to the lungs in the animals by more than 50 percent.

The antibody, named JAA-F11, targets a particular disaccharide, an antigen known as TF-Ag, which aids the adhesion and spread of certain cancer cells. While the antibody did not kill the cancer cells, it blocked stages of cancer-cell growth that allow the cells to adhere to organ tissue, the research showed.

Results of the research appeared in the November 2006 issue of the journal Neoplasia.

Mice with breast-cancer tumors that received the antibody had a median survival time of 72 days, compared to 57 days for the animals that did not receive JAA-F11, the study found. In addition, exposing cultures of tumor cells to the antibody inhibited cell growth by a statistically significant 16 percent.

Kate Rittenhouse-Olson, Ph.D., associate professor of clinical and laboratory sciences in the UB School of Medicine and Biomedical Sciences, is senior author on the study.

"This antibody binds with a carbohydrate on the tumor cell surface that is involved in adhesion of the cell during the metastatic process," said Rittenhouse-Olson. "Not only would drugs attached to the antibody JAA-F11 bind to the tumor cell surface to direct their cytotoxic effect, but the binding of the antibody itself would block the cell from metastasizing."

The antibody was tested using in vitro models of tumor cell growth, in assays to determine its ability to damage or kill cells (cytotoxicity), in various models of cancer metastasis, and, finally, in mice with metastatic breast cancer.

"In addition to providing a survival advantage," said Rittenhouse-Olson, "JAA-F11 immunotherapy reduced the metastatic tumor burden significantly, reflected by both a dramatic decline in the overall
'"/>

Source:University at Buffalo


Page: 1 2

Related biology news :

1. Antibody signal may redirect inflammation to fuel cancer
2. Antibody therapy prevents type 1 diabetes in mice
3. Combined treatment extends life expectancy for lung cancer patients
4. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
5. Viral DNA sequence a possible trigger for breast cancer
6. Used in a new way, RNA interference permanently silences key breast cancer gene
7. Biomarkers isolated from saliva successfully predict oral and breast cancer
8. Study reveals dramatic difference between breast cancers in US and Africa
9. Compounds in plastic packaging act as environmental estrogens altering breast genes
10. Alcohol consumption disrupts breastfeeding hormones
11. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Antibody extends life mice with breast cancer

(Date:7/23/2014)... risk warning for Yellowknife and surrounding area because of ... In the image taken by the Aqua satellite, ... Fire is an obvious health hazard, but the ... obvious and its effects are insidious. , The smoke ... structure, tires, waste or wood burning) is a mixture ...
(Date:7/23/2014)... Roughly 780 million people around the world have no ... Health Organization (WHO), 3.4 million people die from water-related ... the goal of making a contribution to solving this ... Wendelin Stark, head of the Functional Materials Laboratory, the ... developing a prototype. , "What makes our DrinkPure filter ...
(Date:7/23/2014)... Worldwide Innovative Networking in personalized cancer medicine, (the WIN ... at Thomas Jefferson University will be one ... of this prestigious group in the Tri-State Area. The ... innovative personalized medicine to the patient by forging collaborations ... "Our participation in the WIN consortium means Jefferson cancer ...
Breaking Biology News(10 mins):ETH student develops filter for clean water around the world 2New partnership brings more personalized cancer treatment to Philadelphia 2
... engineers and sleep medicine specialists from two Michigan ... put innovative quantitative analysis, signal-processing technology and computer ... One of their recent findings is that a ... distinguish fibromyalgia patients from healthy controls. ...
... BETHESDA, Md. (Sept. 3, 2008) Mice given quercetin, ... were less likely to contract the flu, according to ... study also found that stressful exercise increased the susceptibility ... that negative effect. Quercetin, a close chemical relative ...
... widely cultivated crop that has been subjected to intensive ... years ago). The domestication of grapevine has undergone a ... The recent publication of the complete grapevine genome ... its content. This sequencing has shown that genes constitute ...
Cached Biology News:What a sleep study can reveal about fibromyalgia 2What a sleep study can reveal about fibromyalgia 3Substance found in fruits and vegetables reduces likelihood of the flu 2Substance found in fruits and vegetables reduces likelihood of the flu 3
(Date:7/23/2014)... , July 23, 2014 regulated information -- UCB ... and development pipeline with positive topline results from ... . This study was designed to evaluate the efficacy ... 200 mg/day, without titration) compared to placebo, as ... partial-onset seizures, not fully controlled despite treatment with ...
(Date:7/23/2014)...  Sofinnova Ventures, a Menlo Park ... Sofinnova Venture Partners IX, L.P. at the hard cap ... fund target of $425 million. Sofinnova focuses ... with recent funds, SVP IX will provide capital primarily ... with select investments in earlier stage opportunities. Investments will ...
(Date:7/23/2014)... 23, 2014 OncLive® is pleased ... has joined its Strategic Alliance Partnership program. ... program, UNC Lineberger will have the opportunity to ... of its cutting-edge research initiatives, community-directed cancer prevention ... will work with OncLive to educate their peers ...
(Date:7/23/2014)... July 23, 2014 Astra ... and comprehensive consultancy and pharma training services, and ... Safety (ACRES) , a non-profit integrating the expertise ... and maintain a global system for clinical trials, ... to improve the expertise of industry professionals through ...
Breaking Biology Technology:Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7Sofinnova Raises $500 Million Biotech Venture Fund 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 2Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 3
... , Italian , Japanese and Chinese . ... University of Bristol has developed a new approach to quantum computing ... be done by today,s computers. Scientists from Bristol,s Centre ... used to perform complex calculations and simulations using quantum particles in ...
... NEW YORK, Sept. 16 The 16th Annual National ... Vegas, November 30 – December 3, will focus on ... a time of economic recovery. ErgoExpo,s core educational topics ... workforce, and safety will be coupled with tracks specifically ...
... PRINCETON, N.J., Sept. 16 Novo Nordisk Inc. has been selected ... one of the nation,s top companies for family-friendly benefits. Earlier this ... "100 Best Companies to Work For" and NJBiz,s "Best ... Companies, family programs adeptly help employees in all areas of their ...
Cached Biology Technology:Optical chip enables new approach to quantum computing 2Optical chip enables new approach to quantum computing 32010 National Ergonomics Conference Coming To Las Vegas, Nov. 30 - Dec. 3 With Larger Expo; 22010 National Ergonomics Conference Coming To Las Vegas, Nov. 30 - Dec. 3 With Larger Expo; 32010 National Ergonomics Conference Coming To Las Vegas, Nov. 30 - Dec. 3 With Larger Expo; 4Novo Nordisk Named a 2010 Working Mother 100 Best Company 2Novo Nordisk Named a 2010 Working Mother 100 Best Company 3
... bath, with a comprehensive array of accessories. ... baths with seamless, splash-water protected keypad offer ... (LED) indicating up to 6 temperature values ... MICROPROCESSOR technology with PID temperature control eliminates ...
... Provides a buffered anti-freeze environment for ... Maintains a liquid, low viscosity solution at ... is necessary and sampling is convenient ... during long-term storage Protect enzyme conjugates ...
This buffer is Specifically formulated to be used with Endogen's Poly-HRP Streptavidin...
... SearchLight® Array Analyst Software has been ... arrays. Mathematical algorithms allow the software to ... spot within each well of an ELISA ... SearchLight® Array Analyst Software has been customized ...
Biology Products: