Navigation Links
Antibodies from plants protect against anthrax

Scientists have produced, in tobacco plants, human antibodies that could be used to treat anthrax exposure. They report their findings today at the 2005 American Society for Microbiology Biodefense Research Meeting.

"The nature of bioterrorism is such that an aggressor is likely to strike at a time and place calculated to induce maximum terror through mass casualties. The unpredictable nature of such events compels us to develop cost-effective, highly stable medical countermeasures to enable authorities to treat individuals exposed to bioterror agents such as anthrax," says Les Baillie of the Naval Medical Research Center. Dr. Baillie, who is also associated with the University of Maryland Biotechnology Institute, conducted his research in collaboration with Dr. Vidadi Yusibov, Director of the Fraunhofer USA Center for Molecular Biotechnology (CMB) in Newark, Delaware. Funding for this project at the Fraunhofer USA CMB was obtained through the efforts of a congressional delegation lead by Delaware's Senior Senator Joe Biden.

To create the "plantibodies," Baillie and his colleagues first collected the cells that make antibodies from individuals who had been vaccinated against anthrax. Then genes that encode the antibody itself were inserted into a bacterium that transfers the gene into the plant cells. "The plant makes the antibody for you in a few days," says Baillie.

The antibodies were then purified from leaves harvested from the infected plants and tested for their ability to protect mice against anthrax infection. The plant-produced antibodies were just as effective as the antibodies produced by human cells from immunized individuals.

The antibodies can be used either before exposure to prevent infection or after exposure as treatment.

"If you've been exposed to an agent, you want protection as soon as possible. Vaccination can take a very long time to build immunity. Antibodies give you immediate protection," says Baillie.

"Plant-produced antibodies are also safer because there is no risk of contamination by human or animal pathogens, and plant viruses are not known to infect humans," says Yusibov.

"It is an easy, inexpensive and, very stable system. If you're looking for a way to stockpile a large amount of antibodies for a long periods of time, plant-produced antibodies are the answer," says Baillie.

Anthrax antibodies are just the first step for Baillie and his collaborators. Plantibodies against the plague bacterium and botulism are also in development.


'"/>

Source:American Society for Microbiology


Related biology news :

1. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
2. New RNA polymerase discovered in plants
3. Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
4. Scientists discover how plants disarm the toxic effects of excessive sunlight
5. Defenseless plants arm themselves with metals
6. At long last, scientists figure out how plants grow
7. Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes
8. Engineers improve plastics potential for use in implants by linking it to biological material
9. Innovative coating could give medical implants a longer life
10. Mechanism for the captation of nutrients in plants- unknown to date
11. Its electric: Cows show promise as powerplants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2019)... ... 2019 , ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived ... hosted by Dr. Steven Sampson and Dr. Danielle Aufiero of the Orthohealing Center ... highlighted the ongoing efforts to promote research, educate the public, and provide support to ...
(Date:11/20/2019)... ... 20, 2019 , ... BioInformatics Inc., part of Science and Medicine Group, the ... winners of the Life Science Industry Awards for the most innovative new products in ... Innovation: , Most Innovative New Product – Cell Biology, ...
(Date:11/19/2019)... ... November 19, 2019 , ... The inaugural Cell & ... in New York City. The one-day event will be chaired by Dr Aiman Shalabi, ... in the space. , “We are witnessing significant innovation in cell and gene ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... ... ... a German Shepherd, was demonstrating signs of osteoarthritis in April 2019. He was lame ... his willingness to play were normal, it was clear that he was in pain. , ... Hospital and Referral Center in San Diego, California. Dr. Mullen is an experienced ...
(Date:10/30/2019)... RAPID CITY, S.D. (PRWEB) , ... October 30, 2019 , ... ... a team of researchers and students at South Dakota School of Mines & ... kill cancer cells while leaving healthy cells alive. , If successful, the technique ...
(Date:10/29/2019)... ... October 29, 2019 , ... ... the skin*. Using Silios CMS-C multispectral imagers , researchers identified people by ... replace identification based on retinal imaging, face recognition, fingerprints and vasculature. , ...
(Date:10/22/2019)... ANGELES (PRWEB) , ... October 22, 2019 , ... ... provider, today announced integration of the Alertus Mass Notification System into its digital ... infrastructure to the Enplug platform, making it possible for users to leverage their ...
Breaking Biology Technology: