Navigation Links
Antibiotic inhibits cancer gene activity

A little-known antibiotic shows early promise as an anti-cancer agent, inhibiting a gene found at higher-than-normal levels in most human tumors, according to researchers at the University of Illinois at Chicago College of Medicine.

Their findings appear in the Oct. 1 issue of Cancer Research.

"We chose to target a gene believed to be over-expressed in cancer cells to screen for promising anti-cancer agents," said Andrei Gartel, assistant professor of medicine and of microbiology and immunology at UIC and principal investigator on the study.

The FoxM1 gene is responsible for turning on genes needed for cell proliferation and turning off genes that block proliferation. Uncontrolled proliferation is characteristic of cancer cells.

The researchers developed a new screening system, based on a naturally fluorescent protein called luciferase, to identify small molecules that inhibit proteins that turn genes on and off. Using this system, they identified an antibiotic, siomycin A, that specifically targets FoxM1 without affecting other cell functions.

In further experiments in tissue cultures, the researchers found that siomycin A induced cancer cells, but not normal cells, to commit suicide in a process called apoptosis.

The new screening technique, Gartel said, gives researchers a rapid way to find agents that target oncogenes -- genes believed to cause cancer. He said siomycin A, the first compound found with the method, "is particularly promising because we know that it is not toxic."

Siomycin A must now be tested against other cell lines in the laboratory and in preliminary animal experiments before human trials could be planned. Only a tiny fraction of promising candidate drugs enter clinical trials, and few of those are ever approved.

Gartel said the participation of the late Robert Costa, professor of biochemistry and molecular genetics at UIC and a leader in research on FoxM1, was critical for the success of the project thus far.

Senthil Radhakrishnan, a visiting bioinformatics expert at UIC, is first author of the paper. Uppoor Bhat, Douglas Hughes and I-Ching Wang also contributed to the study.
'"/>

Source:University of Illinois at Chicago


Related biology news :

1. Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey
2. Antibiotic might fight HIV-induced neurological problems
3. New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
4. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
5. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
6. Use of Antibiotics for Acne May Increase Risk of Common Illness
7. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
8. Antibiotic treats lymphoma of the eye
9. Novel antiviral technology inhibits RSV infection in mice
10. Researchers find molecule that inhibits regrowth of spinal nerve cells
11. Techniques available to detect soil that inhibits destructive soybean pest

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
(Date:3/22/2016)... PROVO and SANDY, ... Screening Ontario (NSO), which operates the highest sample volume ... testing, and Tute Genomics and UNIConnect, leaders in clinical ... today announced the launch of a project to establish ... testing panel. NSO has been contracted ...
(Date:3/15/2016)... , March 15, 2016 Yissum Research ... the technology-transfer company of the Hebrew University, announced today ... remote sensing technology of various human biological indicators. Neteera ... $2.0 million from private investors. ... on the detection of electromagnetic emissions from sweat ducts, ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... 04, 2016 , ... PBI-Gordon Corporation is pleased to announce Doug Obermann has ... his career at PBI-Gordon in February 1988, after finishing his masters in agronomy from ... from customer service to national product manager, to helping develop, name and launch many ...
(Date:5/3/2016)... , ... May 03, 2016 , ... ... enterprise talent development, skill-building and compliance training platform on mobile devices, today released ... Overview of Regulatory Requirements for Medical Devices. The course is essential for owners ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... of Dr. Nancy Gillett to its Board of Directors. Dr. Gillett recently retired ... Corporate Executive Vice President and Chief Scientific Officer. A board-certified veterinary pathologist, Dr. ...
(Date:5/3/2016)... - And Other Rising Companies - a ... Biologics  - Biosimilar Drug Producers - Your ... Who are the most important and promising ... potentials? Discover, in our updated survey, organisations, outlooks from ... forecasting. Visiongain,s new study analyses ...
Breaking Biology Technology: