Navigation Links
Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

For the first time, scientists have found that bacteria can use a Sonar-like system to spot other cells (either normal body cells or other bacteria) and target them for destruction. Reported in the December 24 issue of Science, this finding explains how some bacteria know when to produce a toxin that makes infection more severe. It may lead to the design of new toxin inhibitors. “Blocking or interfering with a bacterium’s “detection?mechanism, should prevent toxin production and limit the severity of infection,?says Michael Gilmore, PhD, lead author of the study, and currently director of research at the Schepens Eye Research Institute and professor of ophthalmology at Harvard Medical School.

Gilmore and his team have spent years studying the bacterium known as Enterococcus faecalis, one of the leading causes of hospital-acquired infections, to find new ways to treat them. These infections are frequently resistant to many, and sometimes all, antibiotics. Tens of thousands of deaths due to antibiotic resistant infection occur each year in the US, adding an estimated $ 4 Billion to health care costs. Scientist have known since 1934 that especially harmful strains of Enterococcus produce a toxin that destroys other cells, including human cells and even other types of bacteria. They also knew that this toxin was made only under some conditions. Until Gilmore’s study, scientists were unable to explain how the Enterococcus knew when to make it. In the Science study, Gilmore and his team found that this toxin is made whenever there is another cell type in the environment near the bacterium, such as a human blood cell. They discovered how these bacteria know when other cells are present, and respond accordingly. In the laboratory, the team found that Enterococcus releases two substances into the environment. One substance sticks to foreign cells. The second substance reports back and tells the Enterococcus to make the toxin. If no cells are in the area, the first su bstance sticks to the second, preventing it from reporting back to the Enterococcus, and as a result, no toxin is made. According to Gilmore, “These bacteria are actively probing their environment for enemies or food. Based on whether or not they ‘see?other cells, they make the toxin appropriately.?Gilmore says this discovery has several significant implications for the future. “This is a new mechanism that nature devised to ‘see?the environment, and based on that information, respond accordingly. We may be able to learn from nature and adapt a similar strategy to help the aging population cope with loss of vision,?says Gilmore. “Secondly, this discovery will help us to develop new ways to treat infections that are resistant to antibiotics, making them less severe. Based on an understanding of how this toxin system works, we hope to develop toxin inhibitors,?says Gilmore. The third area of interest is currently science fiction, says Gilmore. “If bacteria can see cells in the environment, maybe we can tame these bacteria and engineer this system so that it can be used to see other things in the environment, such as minerals or possibly other disease-causing bacteria,?says Gilmore.
'"/>

Source:Schepens Eye Research Institute


Related biology news :

1. Antibiotic might fight HIV-induced neurological problems
2. New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
3. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
4. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
5. Use of Antibiotics for Acne May Increase Risk of Common Illness
6. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
7. Antibiotic treats lymphoma of the eye
8. Antibiotic inhibits cancer gene activity
9. Resistant bacteria increasing source of muscle infection
10. Resistant HIV quickly hides in infants cells
11. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
(Date:3/17/2016)... , March 17, 2016 ABI ... intelligence, forecasts the global biometrics market will reach ... impressive 118% increase from 2015. Consumer electronics, particularly ... embedded fingerprint sensors anticipated to reach two billion ... Dimitrios Pavlakis , Research Analyst at ...
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... AVIV, Israel , May 24, 2016   MedyMatch ... providing physicians with artificial intelligence, real-time decision support tools in ... to present at the 2016 Israeli Advanced Technology Industries (IATI) ... of Israel,s 15th National Life Sciences ... 26th at the David Intercontinental Hotel in Tel ...
(Date:5/23/2016)... ... 23, 2016 , ... The need for blood donations in South Texas and across the nation ... Blood & Tissue Center, blood donations are on the decline. In fact, donations across the ... 21 percent in South Texas in the last four years alone. , There is no ...
(Date:5/23/2016)... May 23, 2016 Oxitec CEO ... at 10:15 a.m. ET before the United States House ... engineered mosquitos can play in controlling the spread of the ... Zika virus.      (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) ... with a self-limiting gene. Trials in Brazil ...
(Date:5/23/2016)... Palo Alto, CA (PRWEB) , ... May 23, ... ... tank and public interest organization focused on molecular nanotechnology, announced the winners for ... honor of pioneer physicist Richard Feynman, are given in two categories, one for ...
Breaking Biology Technology: