Navigation Links
Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

For the first time, scientists have found that bacteria can use a Sonar-like system to spot other cells (either normal body cells or other bacteria) and target them for destruction. Reported in the December 24 issue of Science, this finding explains how some bacteria know when to produce a toxin that makes infection more severe. It may lead to the design of new toxin inhibitors. “Blocking or interfering with a bacterium’s “detection?mechanism, should prevent toxin production and limit the severity of infection,?says Michael Gilmore, PhD, lead author of the study, and currently director of research at the Schepens Eye Research Institute and professor of ophthalmology at Harvard Medical School.

Gilmore and his team have spent years studying the bacterium known as Enterococcus faecalis, one of the leading causes of hospital-acquired infections, to find new ways to treat them. These infections are frequently resistant to many, and sometimes all, antibiotics. Tens of thousands of deaths due to antibiotic resistant infection occur each year in the US, adding an estimated $ 4 Billion to health care costs. Scientist have known since 1934 that especially harmful strains of Enterococcus produce a toxin that destroys other cells, including human cells and even other types of bacteria. They also knew that this toxin was made only under some conditions. Until Gilmore’s study, scientists were unable to explain how the Enterococcus knew when to make it. In the Science study, Gilmore and his team found that this toxin is made whenever there is another cell type in the environment near the bacterium, such as a human blood cell. They discovered how these bacteria know when other cells are present, and respond accordingly. In the laboratory, the team found that Enterococcus releases two substances into the environment. One substance sticks to foreign cells. The second substance reports back and tells the Enterococcus to make the toxin. If no cells are in the area, the first su bstance sticks to the second, preventing it from reporting back to the Enterococcus, and as a result, no toxin is made. According to Gilmore, “These bacteria are actively probing their environment for enemies or food. Based on whether or not they ‘see?other cells, they make the toxin appropriately.?Gilmore says this discovery has several significant implications for the future. “This is a new mechanism that nature devised to ‘see?the environment, and based on that information, respond accordingly. We may be able to learn from nature and adapt a similar strategy to help the aging population cope with loss of vision,?says Gilmore. “Secondly, this discovery will help us to develop new ways to treat infections that are resistant to antibiotics, making them less severe. Based on an understanding of how this toxin system works, we hope to develop toxin inhibitors,?says Gilmore. The third area of interest is currently science fiction, says Gilmore. “If bacteria can see cells in the environment, maybe we can tame these bacteria and engineer this system so that it can be used to see other things in the environment, such as minerals or possibly other disease-causing bacteria,?says Gilmore.
'"/>

Source:Schepens Eye Research Institute


Related biology news :

1. Antibiotic might fight HIV-induced neurological problems
2. New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
3. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
4. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
5. Use of Antibiotics for Acne May Increase Risk of Common Illness
6. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
7. Antibiotic treats lymphoma of the eye
8. Antibiotic inhibits cancer gene activity
9. Resistant bacteria increasing source of muscle infection
10. Resistant HIV quickly hides in infants cells
11. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)...  Perkotek an innovation leader in attendance control systems is proud to announce the ... employers to make sure the right employees are actually signing in, and to even ... ... ... ...
(Date:6/7/2016)... TORONTO , June 7, 2016  Syngrafii ... begun a business relationship that includes integrating Syngrafii,s ... pilot branch project. This collaboration will result in ... for the credit union, while maintaining existing document ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... June 23, 2016 On Wednesday, June ... 4,833.32, down 0.22%; the Dow Jones Industrial Average edged 0.27% ... at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the ... Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. ... BIND ). Learn more about these stocks by ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... focused on quality, regulatory and technical consulting, provides a free webinar ... presented on July 13, 2016 at 12pm CT at no charge. , Incomplete ...
(Date:6/23/2016)... SAN FRANCISCO , June 22, 2016  Amgen ... platinum sponsorship of the QB3@953 life sciences ... improve human health. The shared laboratory space at QB3@953 ... startups overcome a key obstacle for many early stage ... As part of the sponsorship, Amgen launched two "Amgen ...
Breaking Biology Technology: