Navigation Links
Anti-fungal drug stops blood vessel growth

Researchers at Johns Hopkins have discovered to their surprise that a drug commonly used to treat toenail fungus can also block angiogenesis, the growth of new blood vessels commonly seen in cancers. The drug, itraconazole, already is FDA approved for human use, which may fast-track its availability as an antiangiogenesis drug.

In mice induced to have excess blood vessel growth, treatment with itraconazole reduced blood vessel growth by 67 percent compared to placebo. “We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis,?says Jun O. Liu, Ph.D., professor of pharmacology. “We couldn’t have predicted that an antifungal drug would have such a role.?

In their search for antiangiogenesis drugs, the researchers worked with cells from human umbilical cords, a rich source of blood vessels, and exposed them to 2,400 existing drugs - including FDA- and foreign-approved drugs, as well as nonapproved drugs that had passed safety trials - to see which ones could stop the cells from dividing.

“The best outcome was to find an already approved drug that worked, and the fact that we did was very satisfying,?says Liu, whose study appears online in ACS Chemical Biology.

As an antifungal drug, itraconazole blocks a key enzyme for making fungal cholesterol, causing these primitive life forms to become fragile and break apart. It turns out that itraconazole can block the same enzyme in blood vessels, but the researchers aren’t positive if that’s the reason blood vessels stop growing, because related antifungal drugs had much lower inhibitory effect.

“Our screening test did show that cholesterol-lowering statins also appear to stop blood vessel growth,?Liu says, “so there is likely some important connection between cholesterol and angiogenesis.?

While the researchers still must tease out exactly how itraconazole works to stop vessel growth, and test it in animals with cancer, th ey have high hopes for its use. “Itraconazole can be taken orally for fungal infection, and therefore oral delivery may work for angiogenesis as well,?Liu notes.


'"/>

Source:Johns Hopkins Medical Institutions


Related biology news :

1. One bacteria stops another on contact
2. Anthrax stops body from fighting back, study shows
3. New compound stops brain cell degeneration in Alzheimers disease
4. RNA interference stops colon cancer spread in mice
5. Insulin receptor stops progression of Alzheimers disease
6. MIT material stops bleeding in seconds
7. Natural protein stops deadly human brain cancer in mice
8. White blood cell waste disposal system plays critical regulatory role
9. Epstein-Barr virus protein crucial to its role in blood cancers
10. New insight into regulation of blood stem cells
11. Nano-bumps could help repair clogged blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... Vortex ... of “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology ” ... result of a collaboration with Dr. Dino Di Carlo and Dr. Matthew Rettig at ...
(Date:5/23/2017)... Switzerland (PRWEB) , ... May 23, 2017 , ... ... forces machine manufacturers to re-engineer their control technology again and again. METTLER TOLEDO ... problem for machine manufacturers. The videos illustrate how integration of the ACT350 into ...
(Date:5/21/2017)... , ... May 20, 2017 , ... ... helps avoid the lengthy trial and error process by finding the right antidepressant ... can also strengthen the doctor-patient relationship through a personalized approach to treatment. ...
(Date:5/18/2017)... , ... May 16, 2017 , ... Clinical Supplies Management ... appointments as the company continues to grow. CSM has doubled in size over ... is executing an aggressive growth strategy. , Roger Gasper joins CSM as Chief Financial ...
Breaking Biology Technology: