Navigation Links
Anti-fungal drug stops blood vessel growth

Researchers at Johns Hopkins have discovered to their surprise that a drug commonly used to treat toenail fungus can also block angiogenesis, the growth of new blood vessels commonly seen in cancers. The drug, itraconazole, already is FDA approved for human use, which may fast-track its availability as an antiangiogenesis drug.

In mice induced to have excess blood vessel growth, treatment with itraconazole reduced blood vessel growth by 67 percent compared to placebo. “We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis,?says Jun O. Liu, Ph.D., professor of pharmacology. “We couldn’t have predicted that an antifungal drug would have such a role.?

In their search for antiangiogenesis drugs, the researchers worked with cells from human umbilical cords, a rich source of blood vessels, and exposed them to 2,400 existing drugs - including FDA- and foreign-approved drugs, as well as nonapproved drugs that had passed safety trials - to see which ones could stop the cells from dividing.

“The best outcome was to find an already approved drug that worked, and the fact that we did was very satisfying,?says Liu, whose study appears online in ACS Chemical Biology.

As an antifungal drug, itraconazole blocks a key enzyme for making fungal cholesterol, causing these primitive life forms to become fragile and break apart. It turns out that itraconazole can block the same enzyme in blood vessels, but the researchers aren’t positive if that’s the reason blood vessels stop growing, because related antifungal drugs had much lower inhibitory effect.

“Our screening test did show that cholesterol-lowering statins also appear to stop blood vessel growth,?Liu says, “so there is likely some important connection between cholesterol and angiogenesis.?

While the researchers still must tease out exactly how itraconazole works to stop vessel growth, and test it in animals with cancer, th ey have high hopes for its use. “Itraconazole can be taken orally for fungal infection, and therefore oral delivery may work for angiogenesis as well,?Liu notes.


'"/>

Source:Johns Hopkins Medical Institutions


Related biology news :

1. One bacteria stops another on contact
2. Anthrax stops body from fighting back, study shows
3. New compound stops brain cell degeneration in Alzheimers disease
4. RNA interference stops colon cancer spread in mice
5. Insulin receptor stops progression of Alzheimers disease
6. MIT material stops bleeding in seconds
7. Natural protein stops deadly human brain cancer in mice
8. White blood cell waste disposal system plays critical regulatory role
9. Epstein-Barr virus protein crucial to its role in blood cancers
10. New insight into regulation of blood stem cells
11. Nano-bumps could help repair clogged blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/2/2018)... ... ... Stuart is a fun-loving eight-year-old Labrador retriever. Like many labs, Stuart’s favorite thing in ... ball so much that whenever anyone comes to our door, he grabs a toy to ... In early 2017, Stuart began limping and eventually could no longer play fetch. Though ...
(Date:10/2/2018)... ... October 02, 2018 , ... The ... 27th, 2018 at Tampa Convention Center. The Palo Alto-based face recognition company, Camvi ... on September 27th. Other speakers included U.S. Federal executives from Department of Defense ...
(Date:10/1/2018)... Mont. (PRWEB) , ... October 01, 2018 , ... ... company advancing targeted antibody drug conjugate (ADC) like, lipid based therapeutics, today announced ... (SBIR) Program had confirmed the award of first year funding for two ...
Breaking Biology News(10 mins):
(Date:9/22/2018)... ... September 20, 2018 , ... Catalent Pharma ... drugs, biologics and consumer health products, today announced that it will be co-hosting ... in Modern Pharmaceutical Development,”. The one-day event is to be held at the ...
(Date:9/15/2018)... ... , ... Next-generation genomic sequencing is transforming what is known about pediatric cancer ... past, the sheer size of genomics data has made sharing across the global scientific ... to advance cures by reducing the technological barriers to data sharing and analysis. Developed ...
(Date:9/13/2018)... ... September 13, 2018 , ... Asymmetrex’s director, James L. Sherley, M.D., ... in medicine, if we didn’t have the means to measure the number of drug ... answer, “Nowhere! And that is what’s holding up progress in stem cell medicine.” , ...
(Date:9/12/2018)... ... 2018 , ... Leading regenerative veterinary medicine company, VetStem Biopharma, ... later this month. The company’s CEO and founder, Dr. Robert Harman, ... chronic kidney disease in felines at a poster session on Saturday, September 29th. ...
Breaking Biology Technology: