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Anti cancer virotherapy well tolerated in first human administration, research finds

Previously the Shafren group has published research on CVA21 that showed success in specifically targeting and killing melanoma cells in mice .

The virotherapy technique involves the specific targeting and killing of cancer cells through the introduction into the body of the appropriate viral material which then reproduces at a rapid rate over a short period of time, devouring the cancer cells in the process by attaching to the cells' ICAM-1 (intercellular adhesion molecule-1) and DAF (decay accelerating factor).

This CVA21 technology which has been identified by Professor Shafren and his team to be effective in killing cancer cells, is on-licensed to Psiron, as has Echovirus Type 1 (EV1), which has shown promise in animal studies in ovarian cancer.

Professor Shafren's research has shown EV1 to be successful in attacking aggressive ovarian cancer cells in the test tube and infected mice .

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Psiron is an anti-cancer biotechnology company focusing on virotherapy. Psiron is developing a suite of viruses for treatment of a range of cancers. Research and development is currently at preclinical stage, progressing to Phase I clinical trials in 2005. Initial clinical trials will be on melanoma and ovarian cancer. More information is available at www.psiron.com


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