Navigation Links
Anti cancer virotherapy well tolerated in first human administration, research finds

An international medical conference here heard that an Australian developed anti-cancer therapy based on the use of a common cold virus to control cancer cell growth has begun safety testing in human subjects.

The research was presented to the third International Meeting on Replicating Oncolytic Virus Therapeutics, on Friday 11 March by Newcastle University associate professor, Darren Shafren.

The technology is licensed to Australian Stock Exchange listed biotechnology company, Psiron Limited (ASX:PSX).

Professor Shafren has previously tested this virotherapy on cancer tumours in mice and this is the first testing in humans. Two patients only were approved to receive this virotherapy.

Professor Shafren reported to the conference that this research team had injected a single dose of Coxsackie A21 (CVA21) virus directly into the advanced melanoma tumours of these patients with end stage disease.

Both patients had many sites of spread melanoma tumours and injected and non-injected tumours were subsequently removed from the patients.

Professor Shafren's group observed no "systemic toxic effects or localised inflammation" as a result of the injections of the viral material and basic blood chemistry and liver enzyme levels remain unchanged in the these two patients.

Professor Shafren told conference delegates that these findings suggested that administration of a single dose of CVA21 directly into a cancerous tumour was well tolerated.

"Administration of CVA21 may be of potential therapeutic benefit in controlling the spread of melanoma," Professor Shafren said.

CVA21 is one of a small group of naturally occurring rather than genetically modified viruses the Shafren team has been investigating as potential therapies for different hard to treat malignancies including melanoma and ovarian cancer.

These viruses occur naturally and routinely in the community causing mild infections in adult humans.
'"/>

Source:SciWords


Page: 1 2

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
3. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Mitochondrial DNA mutations play significant role in prostate cancer
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. BRCA1 causes ovarian cancer through indirect, biochemical route
9. Researchers identify target for cancer drugs
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
(Date:8/20/2014)... scientists have discovered that acral melanomas the rare type ... are genetically distinct from other more common types of ... in the journal Pigment Cell & Melanoma Research . ... hands, soles of the feet, nail-beds and other hairless parts ... it,s not caused by UV damage from the sun. , ...
(Date:8/20/2014)... a chili pepper causes a burning spiciness that is ... the chili pepper,s effect are using their findings to ... pain, which can be caused by inflammation or other ... is being tested in clinical trials, in ACS, ... colleagues explain that decades ago, scientists had pegged a ...
(Date:8/20/2014)... (August 20, 2014) Women who are poor experience ... infants with elevated levels of the stress hormone, ... in life, according to a new research from the ... recently in the American Journal of Human Biology ... and relate it directly to the socioeconomic status of ...
Breaking Biology News(10 mins):Scientists learn more about rare skin cancer that killed Bob Marley 2CU Denver researcher shows economic disparities impact infant health 2
... Ohio, June 27, 2012 Expertise in fluid mechanics at ... research center designed to help physicians better diagnose and treat ... shoulders. Chiari malformation is a disorder of the neurologic ... spinal fluid. UA engineers are able to probe the ...
... is a very small unit, even smaller than the nano ... Alonso has devoted himself to studying green algae of this ... to the area beyond the Nervin estuary. This has enabled ... species that until now had not been catalogued in these ...
... Anatolian Neolithic" is the name of a new multinational ... Commission for the next four years. It is classified ... EU Marie Curie Actions program, which allows young scientists ... A basic requirement for funding is that the researchers ...
Cached Biology News:When does a headache need an engineer to fix it? 2When does a headache need an engineer to fix it? 3A nanoscopic look at the estuary's green algae 2A nanoscopic look at the estuary's green algae 3Mainz University coordinates new EU project on the origins of human settlement 2Mainz University coordinates new EU project on the origins of human settlement 3
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... biopharmaceutical contract development and manufacturing organization (CMO) announced ... Pharmaceuticals, Inc., an oncology company focused on the ... cancer, to manufacture the anti-prostate specific membrane antigen ... product candidate. Under the agreement the antibody ...
(Date:8/20/2014)... university inventions licensed to biotechnology firms has revealed ... open these roadblocks, the researchers suggest that better ... stage could lead to faster commercialization down the ... discoveries made in university laboratories and licensed to ... trials, which have a high failure rate. But ...
(Date:8/20/2014)... High performance computing (HPC) will ... complete climate and Earth system model to address ... , Eight national laboratories, including Lawrence Livermore ... for Atmospheric Research, four academic institutions and one ... national laboratories include Argonne, Brookhaven, Lawrence Berkeley, Los ...
(Date:8/20/2014)... 20, 2014 Not long ago, it ... should be performed late in the development cycle – ... current regulatory trends suggest that, like many things GxP, ... In recent years, multiple drug sponsors have been required ... specific questions during phase I/II. It’s not only clinical ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2
... Health-focused social networks,blogs, wikis and community sites ... can be their biggest opportunities. A marketing,executive ... increasing,importance of reputation monitoring and management in ... Generated Content and Enhancing its Impact,on Your ...
... EASTON, Mass., Dec. 11 Pressure BioSciences, Inc. (Nasdaq: ... Omni International ("Omni") today announced that they have entered ... Under the terms of the Agreement, the companies will: ... competitive information; (2) co-promote certain products at industry trade ...
... adults may be familiar with the,tetanus and diphtheria booster ... a booster shot that protects adolescents and adults from,whooping ... Listen to this report from ... Registered journalists can access video, audio, text, ...
Cached Biology Technology:Exclusive Conference on Managing Your Online Brand: Shaping the Noise from the Blogosphere 2Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 2Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 3Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 4Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 5
... kit contains 5 ml CELLection Dynabeads (4.5 ... the human epithelial antigen EpCAM and DNase ... log enrichment of epithelial tumour cells directly ... cells clumps can be enriched from bone ...
nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA...
Human PDGF R beta MAb (Clone # PR7212)...
... Ambion's ActivePro In Vitro ... an E.coli lysate, synthesizes ... as well as proteins ... than competing kits. This ...
Biology Products: