Navigation Links
Another Look Finds Promising Proteomics Test is Not Biologically Plausible

In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer.

In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimental test intended to identify early ovarian cancer from a small sample of blood is unlikely to lead to a reliable clinical test right away.

After conducting repeated checks of the data that supported the test’s effectiveness, the researchers say their findings indicate that claims about the experimental protein-based assay are not biologically plausible.

“We view this as a cautionary tale. If you are not careful with this new technology, whose quirks we don’t fully understand, you can find results that may be due to something other than biology,?says the study’s lead author, Keith Baggerly, Ph.D., an associate professor in the Department of Biostatistics & Applied Mathematics.

He adds that this study “illustrates the need for researchers to set standards by which to conduct proteomics research,?meaning that protocols involved in these investigations should be common across laboratories so that results from one lab can be verified by others.

"We are moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting better and we are getting more reproducible results.?
Researchers worldwide are excited about the notion of using protein “barcodes?to identify individual cancers before symptoms appear, but Baggerly and others maintain that the promise of this emerging field of proteomics has not yet been met due to the difficulty in finding complex, reproducible patterns of proteins.

According to Baggerly, that now appears to be the case with the experimental ovarian cancer test at issue, which was first proposed in 2002 by researc
'"/>

Source:The University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. Acid rain and forest mass: Another perspective
2. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
3. Study Finds Moderate Hypothermia A Safe Treatment For Traumatic Brain Injury In Kids
4. Comparison of Cocaine, Methamphetamine ‘Highs?Finds Differences
5. Promising new West Nile therapy cures disease in mice
6. Promising therapies for haemophilia & heart disease
7. Promising cell protein may play role in infection and dry eye
8. TrueBlue Archive Will Store Raw Life Sciences Data for Proteomics and Drug Testing
9. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
10. Biologically inspired sensors can augment sonar, vision system in submarines
Post Your Comments:
(Date:7/11/2014)... The Chinese University of Hong Kong, BGI and other ... to salt tolerance, with implication for improving this important ... online in Nature Communications provides an effective ... , Soybean is an important crop for the world. ... less genetic diversities than their wild counterparts. Among the ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... at Chapel Hill shows how a protein may be crucial ... protein, called "eed," is needed for an essential chemical modification ... findings appear in the May 24 issue of the journal ... a new wave of thinking in genetics: that not all ...
... most, the mere mention of the word "virus" stirs ... suffering. But in recent years, scientists have been trying ... the fight against cancer. , Through genetic engineering, viruses ... abilities to infiltrate, commandeer, replicate and destroy, but only ...
... Howard Hughes Medical Institute have succeeded in mapping the ... range of odors, including vanilla, skunk, fish, urine, musk, ... of neural activity represents a significant step in understanding ... in the nose into odor perception in the brain, ...
Cached Biology News:Protein helps regulate the genes of embryonic stem cells 2Turning viruses into allies against cancer 2Turning viruses into allies against cancer 3Turning viruses into allies against cancer 4Decoding the logic of olfaction 2Decoding the logic of olfaction 3Decoding the logic of olfaction 4
(Date:7/11/2014)... July 11, 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. ... (eslicarbazepine acetate) for use as a once-daily adjunctive ... with epilepsy who are not satisfactorily controlled with conventional ... in patients under 18 years of age. ... disorders and according to Epilepsy Canada, it affects 0.6% ...
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... Understanding the need for better quality ... the gap that currently exists in this area, ChanTest ... portfolio of validated ion channel and GPCR cell lines. ... as ion channels control many critical physiological functions throughout ... the potential to treat a variety of human diseases. ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of ... to announce the relaunch of his highly informative blog, now ... called “ What are Stem Cells ?” Dr. Harman’s ... foundation in the basics of stem cell therapy so that ... type of treatment when considering regenerative medicine. , A veterinarian ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... 2011 Emerson Ecologics, LLC, the leading provider ... market, today announced that the company has expanded ... for their full product line of nutritional supplements. ... reversing chronic illness and improving health through science-based ...
... July 13, 2011 Reportlinker.com announces that ... in its catalogue: Industrial ... http://www.reportlinker.com/p0570053/Industrial-Biotechnology-China-News-1106.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Renewable_energy In this ... policy and regulation about biofuel, which include ...
... AMSTERDAM, July 12, 2011 , ... technical and,medical information products and services, today ... SciVal Strata,( http://www.info.scival.com/strata ),a web-based tool focused ... offers researchers and research administrators the,flexibility to ...
Cached Biology Technology:Emerson Ecologics Expands Partnership With Metagenics, Announces National Distribution Agreement 2Emerson Ecologics Expands Partnership With Metagenics, Announces National Distribution Agreement 3Industrial Biotechnology China News 1106 2Industrial Biotechnology China News 1106 3Industrial Biotechnology China News 1106 4Elsevier Integrates New Collaboration Analysis Capabilities Into SciVal Strata to Further Enhance Research Evaluation 2Elsevier Integrates New Collaboration Analysis Capabilities Into SciVal Strata to Further Enhance Research Evaluation 3
... introduced the highly potent TURBO DNase (patent pending) ... was set in DNA removal capabilities. TURBO DNase ... that is much more efficient than wild type ... unwanted DNA. TURBO DNase binds DNA substrates 6-fold ...
... IEC Centra CL3 series is designed ... research and clinical applications at a ... package includes quick connect rotors and ... yet intuitive interface allows you to ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
... DNA Polymerase I Large (Klenow) Fragment, Exonuclease ... lacks both the 5´→3´ and the 3´→5´ ... DNA Polymerase I (1,2). It is used ... strand displacement amplification (5). Klenow Fragment, Exonuclease ...
Biology Products: