Navigation Links
Ancient retrovirus sheds light on modern pandemic

Human resistance to a retrovirus that infected chimpanzees and other nonhuman primates 4 million years ago ironically may be at least partially responsible for the susceptibility of humans to HIV infection today.

These findings, reported by a team of researchers at Fred Hutchinson Cancer Research Center in the June 22 issue of Science, provide a better understanding of this modern pandemic infection through the study of an ancient virus called Pan troglodytes endogenous retrovirus, or PtERV1.

"This ancient virus is a battle that humans have already won. Humans are not susceptible to it and have probably been resistant throughout millennia," said senior author Michael Emerman, Ph.D., a member of the Human Biology and Basic Sciences divisions at the Hutchinson Center. "However, we found that during primate evolution, this innate immunity to one virus may have made us more vulnerable to HIV."

Evidence of human immunity to this ancient retrovirus first emerged with the sequencing of the chimpanzee genome. "When the chimp genome was sequenced, a team of scientists at the University of Washington led by Evan Eichler found the largest difference overall between the chimp and human genomes was the presence or absence of PtERV1," Emerman said. "Chimps have 130 copies of PtERV1 and humans have none."

It is believed that retroviruses have been entering the genome for many millions of years, and so humans share many retroviral DNA fragments with their primate cousins. Such vestiges of primitive infection, rendered inactive by eons of genetic mutation, make up about 8 percent of the human genome.

Innate protection against PtERV1 in humans could be credited, the researchers believe, to the presence of an ancient, rapidly evolving antiviral defense gene called TRIM5a, which produces a protein that binds to and destroys the virus before it can replicate within the body.

"We know that PtERV1 infected chimps, gorillas and old-w
'"/>

Source:Fred Hutchinson Cancer Research Center


Page: 1 2 3

Related biology news :

1. Ancient olfaction protein is shared by many bugs, offering new pest control target
2. Ancient immune defense mechanism is no match for HIV-1
3. Ancient DNA helps clarify the origins of two extinct New World horse species
4. Researchers Discover Ancient Origins Of Tuberculosis-causing Bacteria
5. Ancient DNA confirms single origin of Malagasy primates
6. Ancient anthropoid origins discovered in Africa
7. Ancient trans-Atlantic swarm brought locusts to the New World
8. Ancient humans brought bottle gourds to the Americas from Asia
9. Ancient DNA helps UF researchers unearth potential hemophilia therapy
10. Ancient DNA provides clues to the evolution of social behavior
11. Ancient ants arose 140-168 million years ago
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Ancient retrovirus sheds light modern pandemic

(Date:9/18/2014)... world-leading provider of scientific, technical and medical information ... Society (ARMS), recognized the academic research achievements of ... Researcher of the Year Awards. , The award ... Centre and in conjunction with the ARMS 2014 ... and New Zealand,s scientific community. Guest of honour ...
(Date:9/18/2014)... can swim up to 400 kilometres in search of a ... change. , Clownfish spend their entire adult lives under the ... wander the open ocean, says study co-author, Dr Hugo Harrison ... (Coral CoE) at James Cook University. , "In the past ... given a rare glimpse into how far they can swim, ...
(Date:9/17/2014)... the Arts and Humanities has received a $260,000 grant ... project, "The Boundaries of the Human in the Age ... a wide-ranging series of events aimed at exploring two ... artists and researchers who are exploring the boundaries of ... humanism, and the other involves the increasingly influential hypothesis ...
Breaking Biology News(10 mins):Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Nemo's epic journey to find a new home 2Mellon Foundation awards grant for major project in the humanities and sciences 2
... 31 January 2014 VIB and CD3 (KU Leuven) ... agreement with AstraZeneca for the development of novel MALT1 ... The research teams of Thijs Baens and Peter ... Beyaert (VIB-UGent, Inflammation Research Center) were among the first ...
... University have just published a comprehensive overview of forensic research ... "By pulling all of this information together in one ... some children and find justice for others," says Dr. Ann ... author of the paper. Ross is also co-editor of the ...
... were domesticated more than 15,000 years ago and it ... to form close relationships with humans stems from changes ... on the interactions between the animals have not received ... Range and Zsfia Virnyi, two members of the University ...
Cached Biology News:VIB&CD3 enter into license and collaboration agreement with AstraZeneca for development of MALT1 inhibitor 2Forensic experts compile guide on how to ID child abuse, starvation 2Teaching young wolves new tricks 2
(Date:9/18/2014)... LOUIS , Sept. 18, 2014  U.S. biotech ... by signing an exclusive license for technology developed by ... control gene expression in plants, including for applications in ... The technology was developed under the ... officer at Kultevat and former president of the Danforth ...
(Date:9/18/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... with Merck Animal Health to market Neogen,s Igenity ® ... Dairy Heifer Program consists of genomic tests that offer ... of replacement dairy heifers. The genomic tests can be ... an excellent tool in the decision-making process for breeding ...
(Date:9/18/2014)... YARDLEY , Pennsylvanie, 18 septembre 2014 ... Lyon en 1974, a été ... à compléter les évaluations cliniques traditionnelles par ... Reported Outcomes) et sur les impacts économiques ... http://photos.prnewswire.com/prnh/20140618/119365 A cours ...
(Date:9/18/2014)... OMICS Group International invites researchers, authors and ... ‘Open Access Week’ by actively contributing their research ... Journals from 20-26th October, 2014. , Pharmaceutical ... accelerating with a tremendous speed to provide improved ... industry is gearing with innovation and technological revolution ...
Breaking Biology Technology:Kultevat obtains license of gene switch technology 2Merck Animal Health to market Neogen's dairy genomic program 21974 - 2014 - Mapi fête ses 40 ans 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... Feb. 21 AstraZeneca,believes this lawsuit is legally and ... Supreme Court, if the trial court does not reject ... premise that the,Alabama State Medicaid Agency did not understand ... We believe numerous errors occurred during the proceedings ...
... Today, Nycomed US Inc.,successfully completed the acquisition ... therapeutic markets in the United States. With,this acquisition, ... offered through its PharmaDerm Division and thereby increase,market ... Fougera,Division, which is a leader in the topical ...
... Cardinal Health, a,global provider of products and services ... announced an order by the New York,Department of Health ... expanding statewide plan to maintain emergency response readiness, New,York ... over the past two years., Cardinal Health has ...
Cached Biology Technology:Nycomed US Inc. Acquires Bradley Pharmaceuticals, Inc. 2New York Strengthens Emergency Preparedness with Cardinal Health Ventilators 2
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: