Navigation Links
Ancient immune defense mechanism is no match for HIV-1

terplay between RNAi and SRS remains physiologically conserved from plants and invertebrates to higher vertebrate animals," explains Dr. Jeang. "Our finding that Tat is an SRS also helps explain the long-standing biological observation that when HIV-1 is engineered to be lacking Tat but contains alternative transcriptional activators, it fails to spread productively in human cells." The researchers also suggest that their findings raise a challenge to proposed therapeutic strategies making use of RNAi. "Because HIV-1 evades all other RNAi by point mutations, we reason that its requirement for an SRS is solely to shield this last 'Achilles' heel that we think HIV-1 cannot alter for functional reasons. The sequence we describe may represent a viable target for RNAi that HIV-1 cannot elude by using the point mutation mechanism, " explains Dr. Jeang.

The researchers include Yamina Bennasser and Kuan-Teh Jeang of the National Institute of Allergy and Infectious Diseases; Shu-Yun Le of the National Cancer Institute; and Monsef Benkirane of the Institut de Genetique Humaine, CNRS.

Bennasser, Y., Le, S.-Y., Benkirane, M., and Jeang, K.-T. (2005). Evidence that HIV-1 Encodes an siRNA and a Suppressor of RNA Silencing. Immunity, 22, 607-619. http://www.immunity.com


'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Ancient olfaction protein is shared by many bugs, offering new pest control target
2. Ancient DNA helps clarify the origins of two extinct New World horse species
3. Researchers Discover Ancient Origins Of Tuberculosis-causing Bacteria
4. Ancient DNA confirms single origin of Malagasy primates
5. Ancient anthropoid origins discovered in Africa
6. Ancient trans-Atlantic swarm brought locusts to the New World
7. Ancient humans brought bottle gourds to the Americas from Asia
8. Ancient DNA helps UF researchers unearth potential hemophilia therapy
9. Ancient DNA provides clues to the evolution of social behavior
10. Ancient ants arose 140-168 million years ago
11. Ancient fossil DNA found preserved in crystal
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Ancient immune defense mechanism match for HIV

(Date:8/21/2014)... Aug. 21, 2014 Nxt-ID, Inc. (OTCQB: NXTD), ... commerce market, announced today that its shares of common ... be issued in its proposed underwritten public offering of ... on The Nasdaq Capital Market, subject to closing of ... and warrants, and will trade under the symbol "NXTD" ...
(Date:8/21/2014)... dandruff, eczema and other itchy, flaky maladies in humans ... Hawaiian coral reefs and the extreme environments of arctic ... the scientific journal PLOS Pathogens considers the ... genus Malassezia in light of new insights ... world. , University of Hawai,i at Mānoa scientist Anthony ...
(Date:8/21/2014)... researchers from Beth Israel Deaconess Medical Center (BIDMC ) ... Most Influential Scientific Minds 2014," a comprehensive list ... web resource for science metrics and research performance analysis. ... most influential "are performing and publishing work that their ... science," according to a Thomson Reuters statement. Researchers were ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... at the Virginia Bioinformatics Institute and Duke University ... appears to play an important role in the ... brassicicola, a destructive fungal pathogen that causes black ... results in considerable leaf loss in many economically ...
... practice of killing wild badgers to prevent tuberculosis in ... led by Rosie Woodroffe, an ecologist at the University ... Group on Cattle TB. , In Britain, farming interests ... the merits of culling badgers to fight cattle tuberculosis, ...
... life--large, small, and microscopic. Bacteriophage (phage) viruses are minute, ... their communities through predation and parasitism. Despite their small ... of them in a bucket full of seawater as ... they can have a huge impact ecologically. , ...
Cached Biology News:Tearing down the fungal cell wall 2Tearing down the fungal cell wall 3British cattle give TB to badgers, finds UC Davis expert 2Hundreds of thousands of viral species present in the world's oceans 2
(Date:8/22/2014)... today (August 22nd), in the scientific journal ... Programme establish the effect of serotonin on sensitivity ... and optical techniques., "Serotonin is a small molecule ... of brain functions, from the control of sleep ... behaviours, This neurotransmitter is also popularly thought to ...
(Date:8/22/2014)... Ophthalmic drug delivery technologies or ... endeavors as the anatomy, physiology and biochemistry of ... foreign substances. Ocular drug delivery technologies provide several ... minimal use of needles; also it enables high ... specific targeting within the ocular globe. On the ...
(Date:8/22/2014)... Research and Markets has announced the addition ... Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - ... The global molecular biology enzymes market was ... to grow at a CAGR of 13.74% to reach ... reagents find applications in a large number of fields ...
(Date:8/22/2014)... 22, 2014 The identification of ... can be accelerated by exome sequencing. Built on ... the custom SeqCap EZ Developer system has been ... Watson will additionally present how he achieved coverage ... human and mouse exome kits. With over 236,000 ...
Breaking Biology Technology:From happiness to pain: Understanding serotonin's function 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2
... provides the Company and investor an option to sell or ... purchase additional $67.5 million in securities, SEATTLE, April ... CTIC ; MTA) today announced that it has,entered into agreements ... Series E Convertible Preferred Stock (the "Preferred,Stock"), 13.5% Convertible Senior ...
... 29 Onyx,Pharmaceuticals, Inc. (Nasdaq: ONXX ) today ... discuss first quarter 2008 financial,results and provide a general ... Eastern Time (2:00 p.m. Pacific Time). Financial results for ... earlier that day., Interested parties may access a ...
... SOUTH SAN FRANCISCO, Calif., April 29 ,Anesiva, Inc. ... exclusive Zingo(TM),marketing and distribution agreement, with Green Vision ... powder intradermal injection system is approved in the ... IV insertions or blood,draws in children three to ...
Cached Biology Technology:Cell Therapeutics, Inc. Sells $64.5 million Units Consisting of Preferred Stock, New 2014 Convertible Senior Notes and Warrants to a Single Institutional Investor 2Cell Therapeutics, Inc. Sells $64.5 million Units Consisting of Preferred Stock, New 2014 Convertible Senior Notes and Warrants to a Single Institutional Investor 3Anesiva Announces New Zingo Marketing and Distribution Agreement 2Anesiva Announces New Zingo Marketing and Distribution Agreement 3
Rabbit Polyclonal antibody to Perilipin Applications: This antibody is useful for Western blot anlaysis where a band at ~60 kDa is seen....
... A thermostable, thermoactive designer enzyme ... single-tube-reaction. AccuRT RNA PCR enzyme allows ... be performed at elevated temperatures (65C), ... from the template and results in ...
Request Info...
EML1 (K-16)...
Biology Products: