Navigation Links
Ancient immune defense mechanism is no match for HIV-1

Researchers have discovered that mammalian cells infected with HIV-1 engage a primitive defense mechanism that was previously observed only in plants and invertebrates. The research also reveals exactly how HIV-1 successfully thwarts this rare form of immunity in vertebrate cells. However, elucidation of the mechanism HIV-1 uses to protect itself provides some critical insight into a potential vulnerability within the HIV-1 molecule. Identification of what might be a long sought after weakness in the virus may have application for rational design of future anti-HIV-1 therapies. The study is published in the May issue of Immunity.

RNA silencing is a type of natural immune defense in which sequence-specific RNA degradation follows the recognition of double-stranded RNA (dsRNA). The dsRNA is processed by a protein called Dicer, which chops the long strands of RNA into smaller pieces, resulting in the production of an RNA-induced silencing complex (RISC). RISC can specifically identify and degrade complementary target RNA. This process is known as RNA interference (RNAi) and can silence the ability of a virus to successfully reproduce itself. Although this mechanism has been artificially manipulated to selectively inhibit specific genes in mammalian cells, it was not known whether mammalian viruses naturally elicit this type of immunity in vertebrate cells.

Drs. Yamina Bennasser and Kuan-Teh Jeang from the Molecular Virology Section at the National Institute of Allergy and Infectious Disease and colleagues found that infection with HIV-1 induces RNAi in human cells. However, the researchers discovered that HIV-1 has an intriguing strategy to combat this cellular defense. The HIV-1 protein Tat, well known as a transcriptional activator, also can function as a suppressor of RNA silencing (SRS). Tat helps HIV-1 to elude the cell's natural RNAi defense by interfering with the ability of Dicer to process dsRNAs.

"Our results suggest that the dynamic in
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Ancient olfaction protein is shared by many bugs, offering new pest control target
2. Ancient DNA helps clarify the origins of two extinct New World horse species
3. Researchers Discover Ancient Origins Of Tuberculosis-causing Bacteria
4. Ancient DNA confirms single origin of Malagasy primates
5. Ancient anthropoid origins discovered in Africa
6. Ancient trans-Atlantic swarm brought locusts to the New World
7. Ancient humans brought bottle gourds to the Americas from Asia
8. Ancient DNA helps UF researchers unearth potential hemophilia therapy
9. Ancient DNA provides clues to the evolution of social behavior
10. Ancient ants arose 140-168 million years ago
11. Ancient fossil DNA found preserved in crystal
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Ancient immune defense mechanism match for HIV

(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
(Date:12/10/2014)... 2014  Valencell, a leader in performance biometric data ... demand from its licensees for highly accurate, clinically validated ... solely coming from fitness and health sectors, but first ... wearable is only as useful as the biometric data ... driver in long-term mass consumer adoption of wearable products," ...
(Date:12/10/2014)...     Jifflenow ...   Jifflenow, a leading provider ... business-to-business (B2B) events, today announced a partnership with ... communication (NFC), Bluetooth low energy (BLE), and cloud-based ... Jifflenow will integrate its meeting scheduling ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... available in German . Leaf beetles fascinate ... coloring. Their larvae, however, are dangerous plant pests. Larvae of ... tree species: willow and birch. To fend off predator attacks, ... whose precursors they ingest with their leafy food. Scientists ...
... animals, their genes, and their ecosystems (such as rainforests ... than the last mass extinction 65 million years ago. ... that exist today are estimated to be extinct by ... integral part of this extensive network of life. We ...
... This release is available in French . ... today on the grounds of the Botanical Garden. The new ... the Botanical Garden and the Montral Insectarium, two Espace pour ... facilities for research into biodiversity, its preservation and its promotion. ...
Cached Biology News:Host change alters toxic cocktail 2Host change alters toxic cocktail 3Earth's biodiversity: What do we know and where are we headed? 2Earth's biodiversity: What do we know and where are we headed? 3The University of Montreal Biodiversity Centre opens 2The University of Montreal Biodiversity Centre opens 3
(Date:12/22/2014)... 2014  ( www.competitivehealth.com ) — Competitive Health is ... review and advocacy service, has signed an agreement to ... discount health services marketplace. 63% of Americans ... they expected to pay. As part of an ongoing ... Savings is pleased to offer medical bill review and ...
(Date:12/22/2014)... Chicago, Illinois (PRWEB) December 22, 2014 ... representing tenants and occupiers of commercial real estate, has ... two new offices in Perth and Brisbane, Western Australia, ... board of directors. , ITRA Global / ACORPP ... and totally independent consultancy company providing property services to ...
(Date:12/19/2014)... 19, 2014 Bioject Medical Technologies ... manufacturer of needle-free injection technology, today announced that ... Therapeutics, Inc. (“ITI”) for ITI to use the ... LAMP™ vaccine platform. , In the agreement, ... license to the Biojector®-2000 that triggers based on ...
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... the promotion of Nick Maroulis, Pharm.D. to the newly ... , In this position, Dr. Maroulis will continue ... the directors of our multi-site pharmacies as the company ... and during that time he has served in many ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... , , , , , , , , ... -- NeoStem, Inc.,(NYSE Amex: NBS ) ("NeoStem" or the "Company"), ... , announced,today that it priced a public offering of 5,000,000 shares ... from the offering, after underwriting,discounts and commissions and expenses, will be ...
... , , , , ... 3SBio Inc. ( SSRX),("3SBio" or "the Company"), a leading China ... its unaudited financial results,for the fourth quarter and full year ended ... Financial Highlights:, -- Total net revenues in 2009 increased ...
... growth call for sweeping changes in how the world produces ... including an expert in plant genetics at the University of ... science and technology adviser to Secretary of State Hillary Clinton, ... popular biases against the use of agricultural biotechnology," as well ...
Cached Biology Technology:NeoStem Prices Public Offering of 5,000,000 Shares of Common Stock 2NeoStem Prices Public Offering of 5,000,000 Shares of Common Stock 3NeoStem Prices Public Offering of 5,000,000 Shares of Common Stock 43SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 23SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 33SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 43SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 53SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 63SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 73SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 83SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 93SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 103SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 113SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 123SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 133SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 143SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 153SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 163SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 173SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 183SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 193SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 203SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 213SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 223SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 233SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 243SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 253SBio Inc. Announces Unaudited Fourth Quarter and Full Year 2009 Results 26Dramatic changes in agriculture needed as world warms and grows, researchers say 2
RayBio Human Angiogenesis Antibody Array 2.1 (8 array membranes) with Accessory, detects 23 angiogenic factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
... for cryogenic vials. Racks ... stainless steel boxes for 2ml, ... Vapor phase or Liquid ... risers to be ordered separately ...
Rat CINC-2 alpha/beta Affinity Purified Polyclonal Ab...
Mouse TREM-2 Affinity Purified Polyclonal Ab...
Biology Products: