Navigation Links
An entropy-based gene selection method for cancer classification using microarray data

Accurate diagnosis of cancer subtypes remains a challenging problem. Building classifiers based on gene expression data is a promising approach; yet the selection of non-redundant but relevant genes is difficult. The selected gene set should be small enough to allow diagnosis even in regular clinical laboratories and ideally identify genes involved in cancer-specific regulatory pathways. Here an entropy-based method is proposed that selects genes related to the different cancer classes while at the same time reducing the redundancy among the genes.

Results

The present study identifies a subset of features by maximizing the relevance and minimizing the redundancy of the selected genes. A merit called "uncertainty" is employed to measure the relevance and the redundancy of the genes. In order to find a more representative subset of features, an iterative procedure is adopted that incorporates an initial clustering followed by data partitioning and the application of the algorithm to each of the partitions. A leave-one-out approach then selects the most commonly selected genes across all the different runs and the gene selection algorithm is applied again to pare down the list of selected genes until a "minimal" subset is obtained that gives a satisfactory accuracy of classification. The algorithm was applied to three different data sets and the results obtained were compared to work done by others using the same data sets.

This study presents an entropy-based iterative algorithm for selecting genes from microarray data that are able to classify various cancer sub-types with high accuracy. In addition, the feature set obtained is very compact, that is, the redundancy between genes is reduced to a large extent. This implies that classifiers can be built with a smaller subset of genes.


'"/>

Source:BioMed Central


Page: 1

Related biology news :

1. Cornell finds natural selection in humans
2. Natural selection at single gene demonstrated
3. Embryonic selection of sex avoids conceiving blind children
4. Does natural selection drive the evolution of cancer?
5. Pressured by predators, lizards see rapid shift in natural selection
6. Color-blind method opens new doors in DNA sequencing
7. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
8. Studies reveal methods viruses use to sidestep immune system
9. New methods of gene delivery using lasers
10. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
11. Shift of weather patterns necessitates rethinking of reforestation methods
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2016)... 2016 --> --> ... Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & ... the border security market and the continuing migration crisis in ... Europe has led visiongain to publish this unique ... --> defence & security companies in the border ...
(Date:3/15/2016)... Yissum Research Development Company of the Hebrew University ... University, announced today the formation of Neteera Technologies ... biological indicators. Neteera Technologies has completed its first round ... Neteera,s ... from sweat ducts, enables reliable and speedy biometric identification, ...
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ) - ... Images ( http://www.apimages.com ) - Germany . ... new refugee identity cards. DERMALOG will be unveiling this device, and ... Hanover next week.   --> Germany ... the new refugee identity cards. DERMALOG will be unveiling this device, ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... May 04, 2016 , ... Proove Biosciences, Inc. , ... strategic partnership with McGill University . The partnership is designed to advance research ... order to help patients in pain. With the new agreement, researchers at Proove Biosciences ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nutrafol®, a first-to-market smart-supplement for ... and stress related hair loss. With patent-pending formulas for both female hair loss ... in the medical and salon channels nationwide. , Dermatologists, Plastic Surgeons and ...
(Date:5/3/2016)... ... May 03, 2016 , ... Flagship Biosciences, the leader ... to its Board of Directors. Dr. Gillett recently retired from Charles River Laboratories ... and Chief Scientific Officer. A board-certified veterinary pathologist, Dr. Gillett joined Charles River ...
(Date:5/3/2016)... NY (PRWEB) , ... May 03, 2016 , ... According ... Hospital , for definitive prostate cancer treatment, patients traditionally had two main treatment options: ... treatment plan would be made. , New technology has enabled doctors to administer ...
Breaking Biology Technology: