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Alzheimer's found to be mostly genetic

us research with twins, Gatz identified possible preventive or delaying factors, such as a low incidence of inflammatory disease or a work environment with a high degree of human interaction.

The sample for the study consisted of all participants in the Swedish Twin Registry aged 65 or older in 1998 - the year the study began -- for a total of 11,884 twin pairs.

Of these, 392 pairs showed evidence of Alzheimer's in at least one twin.

In the model that best fit the data, genetic influence accounted for 79 percent of Alzheimer's risk, with 95percent confidence in a range of 67 to 88 percent.

The other 21 percent of Alzheimer's risk was due to non-shared environmental causes. Risk from shared environments, such as childhood settings that were the same for both twins, was statistically negligible.

Genetic risk for Alzheimer's was the same for men and women after controlling for age.

The study is notable for its careful approach to Alzheimer's diagnosis. All individuals were screened for cognitive dysfunction. Suspected cases of dementia, of which Alzheimer's is the most common form, received complete, in-home clinical diagnostic evaluations by a doctor and nurse. Autopsy confirmation of diagnoses is being collected.

The research for this study was supported by grants from the National Institute on Aging and the Alzheimer's Association.

The other USC researcher on the study was co-principal investigator Nancy Pedersen, a research professor with ajoint appointment as professor at Karolinska Institutet.


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Source:University of Southern California


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