Navigation Links
Alzheimer's cognitive decline slowed

ed for the study.

The human clinical trial was undertaken following extensive studies in primates conducted by Tuszynski and colleagues, which showed that grafting NGF-producing tissue into the brains of aged monkeys restored atrophied brain cells to near-normal size and quantity, and also restored axons connecting the brain cells, essential for communication between cells. The recent human studies were a Phase I clinical trial, designed to test safety and toxicity. The procedure was initially performed while patients were awake but lightly sedated, and two patients moved as the cells were being injected, resulting in bleeding in the brain. One of these patients died five week later. As a result of the bleeds, the protocol was redesigned to perform the procedure under general anesthesia and all subsequent procedures were performed without complication.

Cognitive outcomes were assessed in the six patients who completed the NGF delivery procedure safely. The Mini Mental Status Examination (MMSE), which evaluates cognitive function, was administered at screening, the time of treatment and at several intervals after treatment. Over an average post-treatment follow-up period of 22 months, the rate of decline on the MMSE among NGF-treated patients was reduced by as much as 51 percent. An additional test, called the Alzheimer's Disease Assessment Scale-Cognitive Subcomponent, or ADAS-Cog, also showed improvements in rates of decline followed the MMSE findings.

Post-operative PET scans in four subjects showed significant increases in the brain's absorption of a radioisotope called 18-fluorodeoxyglucose, an indicator of increased metabolic activity in the brain. The researchers noted that the increase was observed in most cortical regions that receive cholinergic input from forebrain nerve cells called the nucleus basalis, and in the cerebellum, a structure associated with cortical plasticity.

In addition to Tuszynski, authors of the paper in
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Neuronal traffic jam marks early Alzheimers disease
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Gene vaccine for Alzheimers disease shows promising results
4. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
5. Nanoscale Diagnostic Sets Sights on Alzheimers
6. One gene links newborn neurons with those that die in diseases such as Alzheimers
7. Scientists discover that three molecules may be developed into new Alzheimers drugs
8. Pinpointing a culprit molecule in Alzheimers disease
9. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
10. Hope for Alzheimers blossoms
11. Natural compound from pond scum shows potential activity against Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Alzheimer cognitive decline slowed

(Date:1/22/2015)... Fla. , Jan. 13, 2015  Today, FreeWavz ... technology, launched its crowdfunding campaign on Fundable, ... the build of production capacity to meet customer ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... WINSTON-SALEM, N.C. , Jan. 16, 2015  A man-made ... working memory and other mental capabilities in adults with ... a pilot study led by researchers at Wake Forest ... 60 adults diagnosed with amnesic mild cognitive impairment (MCI) ...
(Date:1/22/2015)... YORK , Jan. 21, 2015  Analyst Report Issued by ... Card Brands report showed that planet-wide, transactions at merchants on ... while the total number of credit, debit, and prepaid cards ... U.S. were victims of fraudulent card usage in 2012, and ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... LEDs to light UT arena . . . ... the University of Tennessee,s Thompson-Boling Arena will become the ... smaller, brighter and up to 85 percent more efficient ... fixtures developed by Oak Ridge-based LED North America incorporate ...
... peninsula of 11,500 km2 within the Arabian Peninsula. Both ... last decades, thus putting a strong pressure on native ... development has triggered a variety of studies of its ... confirmed the occurrence of 21 lizard species, two of ...
... bone marrow cells to deliver potentially curative gene therapy ... syndrome an often fatal condition that causes organ ... Children,s Hospital Medical Center and the National Institute of ... for treating the disease the week of Feb. 3-7 ...
Cached Biology News:Story tips from the Department of Energy's Oak Ridge National Laboratory, February 2014 2Story tips from the Department of Energy's Oak Ridge National Laboratory, February 2014 3Where do lizards in Qatar live? First distribution maps for the state 2Mouse study shows gene therapy may be possible cure for Hurler syndrome 2
(Date:1/22/2015)... GEA Niro Soavi the leader in high pressure ... 2000, which is ideal for new applications for processing ... . This compact laboratory homogenizer is the perfect solution ... additives and ingredients as well as for the ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
(Date:1/22/2015)... Madison, WI (PRWEB) January 22, 2015 Dr. ... at the 12th annual Scripps Natural Supplements Pre-Conference seminar on ... Supplements Conference is an annual continuing education conference for health ... 15th and included the topic of probiotics in health. Dr. ...
(Date:1/22/2015)... BRUNSWICK , Nueva Jersey , 22 de ... Award for Biomedical Research abre hoy su llamada a ... personas cuya investigación científica ha hecho, o tiene el ... la salud humana. Las nominaciones se aceptarán hasta el ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... of the CEOs caught up in the scandals of WorldCom, ENRON, ... Cohen & Grigsby . The people on this video make them ... no regard for people trying to make a living to support ... out there in the last couple of years that have not ...
... they didn't tell Jeanne Moreno when she joined her ... ago. Under the circumstances, she's just fine with that. ... to join a large, global business organization and find ... and obsolete business applications, but compounding the challenge were ...
... , An air ... system, , ... INTRODUCTION, ... label their product as sterile may use compressed,air in various applications. Applications include injection molding, ...
Cached Biology Technology:A disgusting video: U.S. companies sell out Americans 2A disgusting video: U.S. companies sell out Americans 3A disgusting video: U.S. companies sell out Americans 4CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 2CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 3CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 4CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 5Testing Compressed Air Lines for Microbiological Contamination 2Testing Compressed Air Lines for Microbiological Contamination 3Testing Compressed Air Lines for Microbiological Contamination 4Testing Compressed Air Lines for Microbiological Contamination 5Testing Compressed Air Lines for Microbiological Contamination 6Testing Compressed Air Lines for Microbiological Contamination 7
EPA II Buffer is a diluent formulated to stabilize the activity of Chemicon horseradish peroxidase (HRP)-antibody conjugates at high conjugate dilution for extended periods....
... SpliceArray service, ExonHit can design custom microarrays ... your gene list. Proprietary algorithms are ... microarray probes from high quality, spliced cDNAs ... event contained in a custom SpliceArray is ...
... DNA detection has been improved. With Gene Coloring ... can be detected > 20 ng. The excised ... organic solvent extraction or with other commercially available ... DNA excised from agarose gel can be used ...
... SPE Workstation is a modular, highly scalable, ... Utilizing 1ml or 3ml industry standard SPE ... 100 samples in less than two hours ... 10 cartridges, and up to 10 modules ...
Biology Products: