Navigation Links
Agreement will speed research on microbicides for women

cific role in orchestrating the immune response. Defects in TACI were found in 4 of 19 unrelated patients with CVID and in 1 of 16 unrelated patients with IgA deficiency. None of 50 healthy people they studied had a TACI mutation. The scientists believe that it is likely that as yet unidentified genetic defects underlie CVID and IgA deficiency in those cases where TACI was not mutated.

When the scientists further examined four of the five individuals with TACI mutations, they found all four had relatives with the same mutations. Eleven of the 12 identified relatives with CVID or IgA deficiency reported a history of recurrent infections and were also found to have low levels of IgA and/or low levels of another type of antibody, immunoglobulin G (IgG).

TACI mutations interfere with two aspects of the immune response that involve maturation of B cells. Normally, TACI triggers B cells to switch from making immunoglobulin M (IgM), an antibody produced early in the immune response, to making other antibodies such as IgA and IgG. More important, TACI signals B cells to produce antibodies against specific invading bacteria and viruses.

Because TACI mutations are genetically dominant, a person with TACI mutations in one of the two TACI genes he or she inherits is unable to mount a strong antibody response. Each child of a person so affected has a 50 percent chance of inheriting the mutation and being predisposed to IgA deficiency and CVID.

“A test for TACI defects would enable the diagnosis of more children and their relatives with these immune deficiencies,?says Dr. Geha, senior author of the study and the James Gamble Professor of Pediatrics at Harvard Medical School. “Many children who are sick with these disorders are now missed, because they can have normal IgA and IgG levels, yet they still have poor antibody responses and get the same bacterial and virus infections again and again.?/p>

But the gene discovery will not immediately cha
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Affymetrix and bioMerieux Extend Their Agreement on GeneChip(R) Technology to Breast Cancer Diagnostics
2. First atlas of key brain genes could speed research on cancer, neurological diseases
3. Influenza vaccine uses insect cells to speed development
4. Rabies spread speeds up
5. New technique may speed DNA analysis
6. Scientists discover gene that controls speed of tuberculosis development
7. Flies on speed offer insight into the roles of dopamine in sleep and arousal
8. Stressed cells spark DNA repair missteps and speed evolution
9. UW scientists report a new method to speed bird flu vaccine production
10. Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB
11. World first research to speed up cure for ear infections
Post Your Comments:
(Date:12/15/2009)... Dec. 15 The PTR Group, a leading ... that it has agreed to sponsor three high school ... Robotics Competition ( http://usfirst.org ). ,, The ... teams in three different states. The teams from ... TX, and James Madison HS in Vienna, VA all ...
(Date:12/14/2009)... Rice University and Baylor College of Medicine (BCM) have ... real time with MRI as it homes in on ... kills them with heat. The all-in-one particle is one ... "theranostics" that develops technologies physicians can use to diagnose ... research is available online in the journal Advanced ...
(Date:12/14/2009)... that could help wean the nation from oil, would ... gasoline, especially in winter, according to a new study ... both gasoline and E85, a blend of gasoline and ... warm sunny weather than during the cold weather and ... to ozone formation. But E85 produces different byproducts of ...
Breaking Biology News(10 mins):The PTR Group Announces Financial and Technical Support to US FIRST Robotics Competition Teams 2Tracking new cancer-killing particles with MRI 2Ethanol-powered vehicles generate more ozone than gas-powered ones 2Ethanol-powered vehicles generate more ozone than gas-powered ones 3Sun exposure may trigger certain autoimmune diseases in women 53245 1Sun exposure may trigger certain autoimmune diseases in women 53245 2Scientists uncork a potential secret of red wines health benefits 9432 1Scientists uncork a potential secret of red wines health benefits 9432 2Recovery act funded research projects aid communities across the country 9428 1
... Va. -- The National Institutes of Health has renewed ... million to an international biodiversity group lead by David ... Tech. , Kingston is known internationally for his ... agents. Consistent with the Convention on Biological Diversity, he ...
... 2008) Multiple sclerosis is a disease caused by ... fibers of the spinal cord. Therapeutic hope for curing ... possibility that stem cell transplants could help remyelinate the ... (UK) conducted experiments using animal models to see if ...
... of a study funded by the National Environment Research ... School of Biological Sciences and colleagues from Cambridge University ... conference in Spain this week. , The World Conference ... 11 and 15 November. , The Queen,s research forms ...
Other Biology News:Chemist to donate potential pharmaceutical royalties to Madagascar 2Intraspinal implant of mesenchymal stem cells may not heal the demyelinated spinal cord 2Queen's University Belfast researchers trace octopuses' family tree 2
(Date:12/14/2009)... WALTHAM, Mass., Dec. 14 Lionbridge ... it has signed a new, three-year master ... company with products and services that serve ... agreement Lionbridge will become the sole provider ... which includes regulatory, marketing, training, human resources, ...
(Date:12/14/2009)... - Results From a Survey Conducted by ... Major Industrialized Countries , , - A ... impacts their enjoyment of the ... arthritis find shopping for gifts, ... difficult to do, ...
(Date:12/11/2009)... 2009 -- Researchers have discovered a new explanation for differences ... excess copies of a certain gene, the more serious the ... it is suspected that it is the amount of copies ... being published in the American Journal of Human Genetics ... of Guy Froyen connected to VIB, a life sciences research ...
(Date:12/11/2009)... Dec. 11 Marrone Bio Innovations (MBI) ... management team. Mr. Chris Hildreth joined MBI as ... responsible for expanding all commercial aspects of the ... Dr. Kin Sing (Ray) Lam joined MBI as ... company,s development efforts in scaling its broad pipeline ...
Breaking Biology Technology:Multi-Billion Dollar Biotech Firm Chooses Lionbridge as Exclusive Translation Provider with Three-Year Master Services Agreement 2Multi-Billion Dollar Biotech Firm Chooses Lionbridge as Exclusive Translation Provider with Three-Year Master Services Agreement 3Rheumatoid Arthritis Patients Want Pain-Free Days at Christmas 2Rheumatoid Arthritis Patients Want Pain-Free Days at Christmas 3Rheumatoid Arthritis Patients Want Pain-Free Days at Christmas 4Amount of gene surplus determines severity of mental retardation in males 2Marrone Bio Innovations Announces Two New Executive Appointments 2Marrone Bio Innovations Announces Two New Executive Appointments 3
... Martek Biosciences,Corporation (Nasdaq: MATK ) today ... Court in Wilmington, Delaware, has ruled on various,post-trial ... Martek,s favor,against the defendants in the patent infringement ... and Nutrinova Nutrition Specialties &,Food Ingredients GmbH. The ...
... KOOL ), a leading supplier of innovative products ... of,adult stem cells for treatment of disease and injury, ... first quarter ended September,30, 2007, on Thursday, November 8, ... will host a conference call Thursday, November 8, 2007 ...
... - Canadian Biotechnology Company demonstrates the technical feasibility of ... in safflower - ... TSX symbol: SBS, ... company developing a portfolio of therapeutic,proteins for metabolic and cardiovascular diseases, ...
Other Biology Technology:Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 2Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 3ThermoGenesis Corp. to Announce First Quarter Fiscal 2008 Results on November 8, 2007 2ThermoGenesis Corp. to Announce First Quarter Fiscal 2008 Results on November 8, 2007 3SemBioSys announces 2007 third quarter results 2SemBioSys announces 2007 third quarter results 3SemBioSys announces 2007 third quarter results 4SemBioSys announces 2007 third quarter results 5SemBioSys announces 2007 third quarter results 6SemBioSys announces 2007 third quarter results 7SemBioSys announces 2007 third quarter results 8SemBioSys announces 2007 third quarter results 9SemBioSys announces 2007 third quarter results 10SemBioSys announces 2007 third quarter results 11SemBioSys announces 2007 third quarter results 12
... Forma Incubated Orbital Shakers combine ... temperature performance and ease of use. ... vibration, allowing the unit to run ... loads. The unit's class-leading temperature range ...
... The Xcise is a powerful technology ... throughput proteome analysis. High quality sample ... untrained user. , The Xcise is a ... for high throughput proteome analysis. It combines ...
CQCS kit for first KR 4i , (first unit)....
... 384 offers lower consumption of reagents ... applications. The Multidrop 384 is an ... and microvolume dispensing into 384- and ... flexibility. It can easily switch from ...
Biology Products: