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Aging cells, aging body: Fresh evidence for a connection

Presence of these structures signals that the protective chromosome caps called telomeres have dwindled enough to halt cell division.

Scientists painstakingly counted the cells with aging biomarkers. What they found: The number of senescent cells increased exponentially with age. TIF-positive cells made up about 4 percent of the connective tissue cell population in 5-year-olds. In 30-year-olds, that number rose as high as 20 percent.

Director of the Center for Genomics and Proteomics at Brown, Sedivy now plans to track the presence of TIFs in muscle and blood vessels.

"This research confirms that telomeres are important in aging," he said. "But we've only scratched the surface. Now that we've come up with the tools and methods for further TIF research, I am eager to see if the same patterns play out in other tissue."

Brown post-doctoral research fellow Utz Herbig is the lead author of the article. Brown undergraduate Mark Ferreira rounds out the Brown research team. Laura Condel and Dee Carey from the Southwest Foundation for Biomedical Research also contributed.


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Source:Brown University


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