Navigation Links
Aging cells, aging body: Fresh evidence for a connection

Brown University biologists have uncovered intriguing evidence to support the theory that old cells help make old bodies. In a study of baboons, scientists showed that as these animals age, the number of aging cells in their skin significantly increases.

Over time, cells lose their ability to divide, a state known as replicative senescence. The new research, published in an advanced online edition of Science, is the first to quantify the presence of replicatively senescent cells in any species.

"For 40 years, we've known about replicative senescence," said John Sedivy, a Brown professor of medical science and the senior scientist on the project. "Whether it promotes the aging of our bodies, however, is highly controversial. While it may make intuitive sense, skeptics say 'Show us the evidence.' The first solid evidence is in this study. These initial findings won't settle the debate, but they make a strong case."

Human cells replicate anywhere from 60 to 90 times before senescence sets in, a phenomenon scientists believe is a safeguard against disease. While senescent cells still function, they don't behave the way young cells do ?and are associated with skin wrinkles, delayed wound healing, weakened immune system response and age-related diseases such as cancer.

"There is good evidence that senescent cells are not benign," Sedivy said. "But until now, no one has been able to confirm that they exist in appreciable numbers in old animals."

So the Brown team began to study aging animals ?baboons living on a research preserve that ranged in age from 5 to 30. In human years, that age range is roughly 15 to 90.

Veterinarians took small skin samples from the monkeys' forearms. Scientists in the Sedivy lab tested the connective tissue for the presence of six biomarkers, or biological "red flags," that signal cellular aging. For replicative senescence, the most important biomarker is telomere dysfunction-induced foci, or TIFs.
'"/>

Source:Brown University


Page: 1 2

Related biology news :

1. Research on Worms Yields Clues on Aging
2. Cellular Defects in Premature Aging Disease are Reversible
3. Young Blood Revives Aging Muscles, Stanford Researchers Find
4. Gene Expression in the Aging Brain
5. Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging
6. Its never too late to get it back! Aging interrupted
7. Scientists generate patient-specific stem cells, Science study says
8. Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection
9. Drug dials down the energy within cells, UM researchers find
10. New biochip helps study living cells, may speed drug development
11. Cloned mice created from fully differentiated cells, a milestone in cloning research
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Aging cells aging body Fresh evidence for connection

(Date:8/29/2014)... of marine phytoplankton, such as the prolific bloomer ... (thiamine), researchers have discovered. The finding contradicts the common ... eukaryotic microbes depend on scarce supplies of thiamine in ... way to think about the ocean," says CIFAR Senior ... ISME Journal paper with CIFAR fellows John ...
(Date:8/28/2014)... now available from the Lady Bird Johnson Wildflower Center ... harmful non-native plant, insect and other invasive species statewide. ... about $137 billion in economic and other damage annually ... plants and more. , "By having streamlined tools like ... occur, we,re more likely to catch these threats early ...
(Date:8/28/2014)... is available in German . ... owes its name to a striking pattern of blue stripes ... cells, reflective silvery cells, and yellow cells emerge during growth ... as a multilayered mosaic to compose the characteristic colour pattern. ... types have to interact to form proper stripes, the embryonic ...
Breaking Biology News(10 mins):Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Mobile app makes ID of harmful plants, insects in Texas a snap 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... complex analysis of protein interactions, researchers from IRB Barcelona ... mechanisms that may be involved in the development of ... cell biologists, was led by IRB Barcelona group leader ... the Genome Research , a reference journal in ...
... View, Calif. -- 23andMe has launched a project funded ... aimed at validating 23andMe,s highly-scalable platform for pharmacogenomics research. ... American Recovery and Reinvestment Act of 2009 for "Web-based ... NIH,s National Human Genome Research Institute. ...
... French . A mother,s voice will preferentially activate the ... researchers from the University of Montreal and the Sainte-Justine ... discovery after performing electrical recordings on the infants within ... also revealed that while the infants did react to ...
Cached Biology News:Scientists identify the largest network of protein interactions related to Alzheimer's disease 223andMe receives NIH funding to evaluate web-based research on the genetics of drug response 2Allô allô! Mom's voice plays special role in activating newborn's brain 2
(Date:8/29/2014)... York (PRWEB) August 29, 2014 ... at $5.6 billion in 2019. It is expected ... 2013 to 2019, and was valued at $1.8 ... published by Transparency Market Research. , For more ... http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, titled ...
(Date:8/29/2014)... Three Lawrence Livermore researchers have ... Production R&D Award for their research in ... sunlight. , Shared with collaborators from the National ... Nevada, Las Vegas (UNLV), the award recognizes the ... solar-hydrogen production and corrosion processes. , These models ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Best Sanitizers, ... for the food processing industry, is asking industry professionals ... side comparison of the E2 soap they’re currently using ... Foam Soap . Hand hygiene is critical to ... food processing environment. Six key criteria are identified to ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire/ ... new market research report is ... Whole Exome Sequencing Market ... Preparation, Target Enrichment), by Services ... Synthesis), by Application (Cancer, Monogenic ...
Breaking Biology Technology:Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Livermore Team Awarded for Hydrogen Production Research 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13
... 15, 2011 Amsterdam Molecular Therapeutics (Euronext: AMT), ... today that the Company has a negative equity position, as ... negative equity position is in line with previous guidance that ... alternatives for additional financing. AMT announced on November ...
... 2011 National Ergonomics Conference and Exposition (ErgoExpo) held at Caesars ... largest annual gathering of ergonomics decision makers and vendors in ... the last few hours of the show, the room still ... renewed and new exhibitors had signed up for 2012.  ...
... December 14, 2011 Elsevier, a world-leading ... services, and the Federation of Biochemical Societies (FEBS) announced ... an open access journal. The journal is dedicated to ... in both health and disease. , ,In launching this ...
Cached Biology Technology:Amsterdam Molecular Therapeutics Announces Negative Equity Position 2Amsterdam Molecular Therapeutics Announces Negative Equity Position 32011 ErgoExpo Attendees' Choice Award Winners Announced During Sold Out Expo; Exhibitor Renewal for 2012 Hits 96% and Counting 22011 ErgoExpo Attendees' Choice Award Winners Announced During Sold Out Expo; Exhibitor Renewal for 2012 Hits 96% and Counting 3Elsevier and Federation of Biochemical Societies Launch New Journal: FEBS Open Bio 2Elsevier and Federation of Biochemical Societies Launch New Journal: FEBS Open Bio 3
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
Rabbit polyclonal to Reptin/TIP49B/RUVB2 ( Abpromise for all tested applications). Antigen: Synthetic peptide (Human) Entrez Gene ID: 10856 Swiss Protein ID: Q6FIB9...
Goat polyclonal to ORC2L ( Abpromise for all tested applications). entrezGeneID: 4999 SwissProtID: Q13416...
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: