Navigation Links
Age-related changes in DNA repair illuminate the connection between age and genetic damage

Researchers have uncovered a new way in which the aging process is linked to DNA damage--which occurs normally as a result of cell metabolism and environmental influences--and the various ways in which cells repair that damage. In the new work, researchers found that cells in young fruit flies make use of a different mix of molecular DNA-repair mechanisms compared to cells in older flies. The findings are reported by William Engels and colleagues at the University of Wisconsin and appear in the October 24th issue of the journal Current Biology, published by Cell Press.

DNA repair is essential for the accurate preservation of genetic information and to ensure the healthy functioning of cells, and a connection between aging and DNA damage has long been suspected. One line of evidence supporting the connection is that defects in certain genes needed for DNA repair produce maladies that mimic those of accelerated aging. In humans and other mammals, these effects include elevated occurrence of malignancies, osteoporosis, hearing loss, graying of hair, and hair loss. It is also known that DNA damage accumulates with age in cells of a variety of tissue types.

Breaks in the DNA chain have a variety of causes and occur frequently in the course of natural cellular processes. Repairing such breaks is an essential but hazardous process, often leaving missing or added bases at the point of repair. Cells possess a variety of methods for repairing broken DNA, and the cell's "choice" of how to repair a particular break can be critical. Some repair methods are simple but error prone, whereas the more accurate methods have elaborate molecular requirements and are probably much slower.

The new results show that the reproductive cells of young flies tend to use the rough-and-ready repair processes that do not involve extensive DNA synthesis and do not require a matching DNA template for the repair. As the organisms age, however, the same kind of DNA breaks a re repaired primarily by the slower but much more accurate methods that make use of a matching template. These findings raise the question of whether the rapid but risky methods of DNA repair used by cells of young individuals contribute to the accumulation of genetic damage, and perhaps to the aging process itself. Older cells may use the safer repair methods, but they still carry the genetic damage incurred during DNA repair in the fly's "reckless" youth.
'"/>

Source:Cell Press


Related biology news :

1. Researchers trace evolution to relatively simple genetic changes
2. Plants defy Mendels inheritance laws, may prompt textbook changes
3. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
4. Customized gene chip provides rapid detection of genetic changes in childrens cancer
5. New amphibian species result from exploration, not from rule changes
6. Embryonic stem cells accrue genetic changes
7. New view of cancer: Epigenetic changes come before mutations
8. Meditation associated with structural changes in brain
9. Bird song changes sound alarm over habitat fragmentation
10. Ocean dead zones trigger sex changes in fish, posing extinction threat
11. Genome changes tracked during multiple myeloma initiation, progression and treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
Breaking Biology News(10 mins):
(Date:9/14/2017)... ... September 14, 2017 , ... Boston Strategic Partners, ... with Health Economics and Outcomes Research (HEOR) and ‘big data’ to provide in-depth ... US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent on hospitalizations. BSP ...
(Date:9/14/2017)... ... September 14, 2017 , ... ... exploratory analytics solutions, today announced that its Anzo Smart Data Lake has been ... list includes technologies and solutions that help organizations succeed in surpassing their knowledge ...
(Date:9/12/2017)... NJ (PRWEB) , ... September 12, 2017 , ... ... of the fastest growing b2b product testing and development companies will be exhibiting ... service offerings. , Contract Pharma is an educational conference ...
(Date:9/12/2017)... Pittsburgh, PA (PRWEB) , ... September 12, 2017 ... ... Program Committee is extremely pleased to announce that Jeremy Nicholson, Head of the ... Faculty of Medicine, will deliver the 2018 Wallace H. Coulter Lecture. His ...
Breaking Biology Technology: