Navigation Links
After a time-shift, mixed signals from the circadian clock

Circadian rhythms in mammalian behavior, physiology, and biochemistry are controlled by the central clock within a brain structure known as the suprachiasmatic nucleus (SCN). The clock is synchronized to environmental cycles of light and dark. It is well known, from everyday experience, that adjusting to new light schedules takes several days, though the details of how this adaptation takes place are not well understood. Researchers now report findings that suggest this adaptation process does not necessarily involve a gradual and synchronous adaptation by the neurons that comprise the central circadian clock--rather, that different components of the clock tend to adapt to a shifted light schedule at two different speeds.

The work is reported in the May 24 issue of Current Biology by a research team led by Johanna H. Meijer of Leiden University Medical Center in The Netherlands.

The researchers studied clock-resetting behavior in rats that were exposed to a six-hour delay of the light schedule, a shift that mimics a transition from the eastern U.S. to western Europe. By performing electrophysiological analysis of cells that constitute the central circadian clock, the researchers made a surprising discovery: one part of the clock mechanism, represented by a dorsal (upper) group of cells, exhibited oscillations in activity that corresponded to slow resetting of the clock in response to the shifted light schedule, while another part of the clock, represented by a ventral (lower) group of cells, exhibited a distinct pattern of activity that corresponded to fast resetting of the clock.

Perhaps contributing to the different behavior of the two groups of clock cells are the effects on these cells of the neurotransmitter GABA, which the researchers found to excite the cells of the dorsal SCN while inhibiting neurons in the ventral SCN. Because GABA transmits information between the ventral and dorsal SCN, such differences in effect might influence, in
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Bone Density Recovers After Teens Stop Injected Contraceptive
2. Youth With HIV Take More Risks After New Meds Introduced
3. Drug Offers Alternative to Surgical Treatment After Miscarriage
4. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
5. After the yeast is gone bacteria continue to develop flavor of sparkling wine
6. Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack
7. Plants respond similarly to signals from friends, enemies
8. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
9. Scientists discover that three overlapping signals in embryo help get the backbone right
10. Researchers make surprise discovery that some neurons can transmit three signals at once
11. Structure-building cell signals also may influence learning and memory
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: After time shift mixed signals from the circadian clock

(Date:4/17/2014)... honeybees in Europe, Asia and the United States are ... be impacting native honeybee populations at this time, according ... include including Nosema microsporidia and Varroa ... resilient to these invasive pests, which suggests to us ... Asia and the United States currently are not necessary ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
(Date:4/17/2014)... the University of Texas Medical Branch at Galveston ... treated with radiation for cervical cancer should begin ... , The UTMB researchers, finding a high incidence ... treated with radiation, offer new recommendations that the ... screening about eight years after their initial cervical ...
Breaking Biology News(10 mins):East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Methane climate change risk suggested by proof of redox cycling of humic substances 2Radiation therapy for cervical cancer increases risk for colorectal cancer 2
... Permanently Disposes Magnetically Recorded Data to Help QSGI,s ... Calif., Feb. 18 Fujitsu Computer Products of ... products including hard disk drives, peripherals and biometric ... using the Fujitsu Mag EraSURE degaussing ...
... In late 2007, hundreds of dead and stranded seabirds ... feathers saturated with water and coated with an unknown ... massive "red tide" bloom of marine algae had produced ... from the birds, feathers. This is the ...
... French . , Montreal, February 20, 2009 ... birds, and provides clues that can be applied across the ... Biology Letters , shows that Herring and Ring-billed gulls ... to assure their survival. Contrary to previous beliefs, this study ...
Cached Biology News:QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 2QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 3QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 4QSGI Integrates Fujitsu Mag EraSURE Data Degausser into its Suite of Information Technology Security Services 5Study links seabird deaths to soap-like foam produced by red-tide algae 2Study finds life-saving trend among seagulls 2
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
(Date:1/14/2014)... During the 1600’s through the 1800’s doctors contributed unknowingly ... this time period, doctors did not know that they needed ... death of vulnerable patients. In the same way, medical interns ... unwittingly transmitting herpes viruses to their patients. The CBCD explains. ...
(Date:1/14/2014)... 2014 Holloway America today announced an ... test reports (MTRs) for all pressure vessels and tank ... is particularly important for equipment that must meet ASME, ... features search functionality that allows authorized users to quickly ...
Breaking Biology Technology:The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 2Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 3
... the leading,manufacturer of specialized graphics solutions, confirms that ... controller boards with its,ME/CCL medical LCD displays., ... single-slot board with,all-digital, triple-monitor output and the flexibility ... resolutions from <1MP to,8MP with up to 1GB ...
... that included numerous medications, trips to the emergency room and surgery to ... Unit at an Ohio hospital. Both sides of his heart were dying ... ... TUCSON, Ariz. (Business Wire EON) October 8, 2008 -- "I swelled ...
... transport and ... storage of purified DNA, ... room temperature biosample management, announces the launch,of an innovative new ... built-in oxidative protection and,antimicrobial activity for dry, room temperature transport ...
Cached Biology Technology:Totoku Europe Chooses Matrox Xenia(TM) Series to Drive Medical Monitors 2 "Put Down the BBQ Ribs, We've Found You a Donor Heart," Nurse Tells Patient : Ohio Father near Death Gets Second Chance at Life with CardioWest&#8482; temporary Total Artificial Heart 2GenVault Corporation Launches GenTegra(TM) DNA 2GenVault Corporation Launches GenTegra(TM) DNA 3
... culture or fermentation is the ability to ... make rapid adjustments in response to changes ... provide immediate analysis of key nutrients, metabolites, ... media. BioProfile analyzers are fully automated, multi-test ...
... AAIPharmas Routine Testing Laboratory (RTL) ... developed over 25 years. ,,Microbial method ... used to monitor the conditions of ... quality for manufactured products,,We offer a ...
... sequence corresponds to residues 115-133 of rat SAP97. The sequence ... L - P - S - E - R - I ... N - E - V - L - G - P ... conjugation and is not a part of the native rat SAP97 ...
... for which no antibody exists? Having difficulty generating ... a variety of pharmaceutical, biotech and academic researchers ... technology and expertise in antibody generation to work ... RabMAb development technology , High affinity and high ...
Biology Products: