Navigation Links
Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

A team of Howard Hughes Medical Institute (HHMI) scientists has peeled back some of the mystery of how cells are able to turn off genes selectively to control critical events of development. The new insights arise from the first clear molecular images of the structure of Dicer, an enzyme that enables cells to dissect genetic material precisely.

The finding, which is reported in the January 13, 2005, issue of the journal Science by an HHMI research team at the University of California, Berkeley, provides scientists with new information about a mechanism that enables cells to silence genes, a process that governs key developmental events ranging from brain development to stem cell differentiation.

The study was led by Jennifer A. Doudna, a Howard Hughes Medical Institute investigator at the University of California, Berkeley. Doudna's research team used x-ray crystallography to assemble a detailed three-dimensional picture of an enzyme known as Dicer. In cells, Dicer jumpstarts RNA interference, a process that causes genes to be turned off and which, in turn, prompts a host of key developmental events.

With the structure of Dicer solved, Doudna's group showed that the enzyme is more than a molecular cleaver -- it also carefully measures and snips strands of RNA into precise increments. When Dicer cleaves large strands of RNA into smaller fragments, it initiates the process of RNA interference, which can turn genes off and thereby dictate key developmental events.

"The bottom line we've learned from the structure is that Dicer is a molecular ruler," Doudna explained. "It gives us a lot of insight into how the mechanism works."

Dicer, which is ubiquitous in the cells of higher animals, including humans, is a widely studied molecule. It was first discovered in 2001 by Gregory J. Hannon, an HHMI investigator at Cold Spring Harbor Laboratory, and has become a powerful laboratory tool to study cancer and other developmental events thr
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3 4

Related biology news :

1. Applied Biosystems Introduces Advanced Gene Expression Service Provider Program
2. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
3. New comparative toxicogenomics database
4. Measuring the impact of post-genomics on Mediterranean populations
5. Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
6. Enlisting genomics to understand flu evolution
7. Drawing with DNA: Bioart illuminates genomics
8. Study reveals genomics of inflammation from severe injury
9. NIH launches comprehensive effort to explore cancer genomics
10. Environmental metagenomics diagnosing extreme environments, tapping opportunities for clean energy
11. Ticks, flukes, and genomics: Emerging pathogens revealed
Post Your Comments:
(Date:8/1/2014)... eye diseases is tricky enough. Knowing what causes them ... Now, University of Iowa researchers have created the most ... human eye long associated with blinding diseases, such as ... of proteins in the choroid, which supplies blood and ... By seeing differences in the abundance of proteins in ...
(Date:8/1/2014)... most diverse families in the ocean today -- marine ... more than 400 million years ago in the Silurian ... its modern members. This Geology study by ... on 25 July 2014, tracks the remarkable evolutionary expansion ... is origin, the Lucinidae family remained at very low ...
(Date:8/1/2014)... co-authors of a new study, including two Simon ... scientists, industry representatives and policymakers must collaborate closely ... shale gas development. Viorel Popescu and Maureen Ryan, ... Biological Sciences department, are among eight international co-authors ... in Ecology and the Environment . , Shale ...
Breaking Biology News(10 mins):A map for eye disease 2Symbiotic survival 2Symbiotic survival 3Symbiotic survival 4Symbiotic survival 5Symbiotic survival 6Symbiotic survival 7Symbiotic survival 8Symbiotic survival 9Symbiotic survival 10Symbiotic survival 11Symbiotic survival 12Symbiotic survival 13Symbiotic survival 14Scientists warn time to stop drilling in the dark 2Scientists warn time to stop drilling in the dark 3
... Colorado and TUSTIN, Calif., April 21, 2009--Peregrine ... biopharmaceutical company developing monoclonal antibodies for the ... today reported that two preclinical studies presented ... provided further confirmation of the immunomodulatory mechanisms ...
... 50 years as one of the most effective treatments ... been entirely sure exactly how it operates in the ... scientists suggests a mechanism for how Lithium works, opening ... tests on cells have shown that Lithium affects a ...
... MEDFORD/SOMERVILLE, Mass. -- A collaborative team of student designers, ... and Tufts University will use Earth Day as an ... a house that will be solar powered, attractive and ... April 22, at 11:00 a.m. at Sophia Gordon Hall ...
Cached Biology News:Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies 2Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies 3Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies 4Tufts students host Earth Day with groundbreaking ceremony for solar house 2Tufts students host Earth Day with groundbreaking ceremony for solar house 3
(Date:7/31/2014)... see through organs and even the entire body to ... cellular structures has been a long-time dream of biologists. ... 31st in the journal Cell has now ... making opaque organs, bodies, and human tissue biopsies transparent, ... protocols could pave the way for a better understanding ...
(Date:7/31/2014)... BLOOMINGTON, Ind. -- Chemists at Indiana University Bloomington ... in bricks-and-mortar fashion, a development with potential value ... as field-effect transistors and photovoltaic cells. , Their ... 3D Crystalline Solids and 2D Self-Assembled Crystals," has ... a journal of the Royal Society of Chemistry. ...
(Date:7/31/2014)... , July 31, 2014 According ... Research "Quantum Dots Market - Global Industry Analysis, Size, ... market was valued at USD 88.5 million in 2011, ... 2023, growing at a CAGR of 53.8% from 2013 ... Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand ...
(Date:7/31/2014)... July 31, 2014 Graphite Metallizing Corporation ... temperature oven carts. These bearings are uniquely suited to ... ball bearings because of the high temperatures . ... help from the design engineers at Graphite Metallizing to ... process. During their manufacturing operation, pans containing blocks of ...
Breaking Biology Technology:See-through organs and bodies will accelerate biomedical discoveries 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3
... Nile Therapeutics,Inc. (OTC Bulletin Board: NILT.OB), a ... today announced the,appointment of Gregory W. Schafer to ... audit committee. Mr. Schafer is a seasoned biotechnology ... finance and operations., "We are delighted to ...
... Lentigen Corporation today announced,the appointment of Tim Ravenscroft ... chairman, commented, "The board of Lentigen,is delighted that ... are about to enter,clinical trials for our first ... particularly strong background and global leadership in,healthcare products ...
... Arno Therapeutics, Inc., a,privately held drug development ... license agreements with The Ohio State University,("OSU") for ... therapies for cancer., Pursuant to the license ... for the treatment of cancer, including OSU-03012 (NSC,D728209) ...
Cached Biology Technology:Nile Therapeutics Appoints Gregory W. Schafer to Board of Directors 2Nile Therapeutics Appoints Gregory W. Schafer to Board of Directors 3Lentigen Appoints Tim Ravenscroft as Chief Executive Officer 2Arno Therapeutics Completes License Agreements for the Exclusive Rights to Novel, Targeted Cancer Compounds 2Arno Therapeutics Completes License Agreements for the Exclusive Rights to Novel, Targeted Cancer Compounds 3
... The Brownlee Precision Model 440 incorporates ... circuitry in a friendly easy-to-use instrument. Each ... amplifier, an 8-pole Bessel lowpass filter, a ... output offset controls. A control knob sets ...
... versatile & modular instrument which can be used ... Extracellular, Transducer & Multi-channel Isolated Amplification ... Supply unit (NL900D) forms the heart of every ... by this unit, but wiring within the case ...
Rat Epidermal Keratinocytes (REK) (>500,000 cells)...
... The Brownlee Precision Model 410 is a ... used to amplify small signals from sources which ... frequency noise. Each channel consists of a high ... 2-pole lowpass filter, and an output offset control. ...
Biology Products: