Navigation Links
Adding radiation decreases breast cancer recurrence

Radiotherapy after breast conserving surgery for breast cancer reduces recurrence and prevents development of additional breast tumors in older women with early stage breast disease, according to a new study. Published in the March 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study suggests that women also benefit from the recommended five years of tamoxifen treatment for hormone responsive tumors. Among women over 65 and treated with breast conserving surgery, the risk of local or regional recurrence increased up to 3.5 times if they did not receive radiation after their surgery.

Great strides have been made in breast cancer treatment. Breast conserving surgery in combination with radiotherapy and mastectomy provide women with two good options for their initial treatment. Augmenting surgery with hormone modulating drugs, such as tamoxifen, further improves survival and reduces recurrence.

Women over 65 are at the highest risk for breast cancer and make up half of those diagnosed. However, they are less likely to receive standard therapy, particularly radiotherapy after breast conserving surgery, than younger women. Making treatment recommendations for older patients, who may have more comorbidities than younger patients, is complicated by under-representation of older women in clinical trials and prognostic studies.

Led by Ann M. Geiger, M.P.H., Ph.D., of Wake Forest University School of Medicine and formerly of Kaiser Permanente Southern California, researchers retrospectively followed 1,837 women over 65 for ten years who were treated with surgery for early stage breast cancer to examine the impact of treatment on the occurrence of recurrent and additional breast tumors for this patient population. This analysis was part of a larger study led by Rebecca Silliman, M.D., Ph.D., of the Boston University Medical Center. It was conducted under the auspices of the National Cancer Institute-funded Can cer Research Network.

They found that women, regardless of age or comorbidities, who underwent breast conserving surgery but no radiotherapy, were more likely to have recurrence of disease or develop additional breast tumors compared to women who received breast conserving surgery and radiation or mastectomy alone. The risk was highest for local and regional recurrence. These results held regardless of tamoxifen treatment, suggesting that adjuvant radiation treatment was highly effective.

In addition, the researchers found that women who received less than one year of tamoxifen were more likely to have disease recurrence or develop additional breast tumors compared to women who completed the recommended five year course.

Based on these study findings, the authors "recommend that mastectomy or breast conserving surgery with radiation therapy, along with adequate duration of adjuvant hormonal therapy for hormone-responsive tumors, be considered standard therapy in women of all ages and comorbidities, excepting those with very limited life expectancies."

Source:John Wiley & Sons, Inc.

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Gene therapy may protect normal tissues during radiation retreatment for lung cancer
3. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
4. One therapeutic dose of radiation causes 30 percent spongy bone loss in mice
5. Gene therapy protects mice from the effects of whole-body irradiation
6. Cancer stem cells linked to radiation resistance
7. Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage
8. Intravenous gene therapy protects normal tissue of mice during whole-body radiation
9. New way of tracking muscle damage from radiation
10. Men with prostate cancer avoid radiation due to misconceptions
11. Researchers uncover protection mechanism of radiation-resistant bacterium

Post Your Comments:

(Date:6/21/2016)... British Columbia , June 21, 2016 /PRNewswire/ ... appointed to the new role of principal product ... been named the director of customer development. Both ... NuData,s chief technical officer. The moves reflect NuData,s ... teams in response to high customer demand and ...
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
(Date:6/7/2016)... June 7, 2016  Syngrafii Inc. and San ... relationship that includes integrating Syngrafii,s patented LongPen™ eSignature ... This collaboration will result in greater convenience for ... union, while maintaining existing document workflow and compliance ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the ... the Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s ... how hardware projects are designed, built and brought to market. , The Design ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
Breaking Biology Technology: