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Activation of thermoreceptors mediates raw garlic's burning pungency

TRPV1 and TRPA1 and as the likely key chemical component responsible for garlic's pungency. Allicin is converted to a variety of more stable sulfide compounds over time or with heating, in correspondence with the significantly milder taste of roasted garlic.

Garlic's pungency most likely evolved as a defense mechanism against browsing by animals, and indeed many animals--though clearly not all humans--are known to be repelled by it.

The researchers include Lindsey J. Macpherson, Michael Bandell, Samer R. Eid, SunWook Hwang, and Ardem Patapoutian of the The Scripps Research Institute; Bernhard H. Geierstanger, Veena Viswanath, Michael Bandell, SunWook Hwang, and Ardem Patapoutian of the Genomics Institute, Novartis Research Foundation; and SunWook Hwang of the College of Medicine, Korea University. The authors are supported by grants from the National Institute of Neurological Disorders and Stroke. S.R.E. is supported by a fellowship from the Swiss Foundation for Medical-Biological Stipends. A.P. is a Damon Runyon Scholar.

Lindsey Macpherson, Bernhard H. Geierstanger, Veena Viswanath, Michael Bandell, Samer R. Eid, SunWook Hwang, and Ardem Patapoutian: "The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin." Current Biology, Vol. 15, 929?34, May 24, 2005. http://www.current-biology.com


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Source:Cell Press


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