Navigation Links
Activation of microRNA inhibits cancer gene in human cancer cells

Scientists report that tumor cells display a dramatic reduction of cancer-causing genes when a newly discovered method is used to activate the expression of protective microRNAs in the cancer cell genome. The research, published in the June issue of Cancer Cell, demonstrates that agents known to regulate gene expression can also impact regulatory RNAs that may function as tumor suppressors in normal cells and proposes a novel strategy for treating human cancers.

DNA methylation and histone deacetylation are epigenetic processes involved in the regulation of gene expression. In the case of cancer, these processes are thought to turn off genes that may protect cells from abnormal cell growth. Drugs that inhibit DNA methylation and histone deacetylation, known as chromatin-modifying drugs, can reactivate genes that have been abnormally silenced in cancer cells. It is conceivable that these processes may also regulate expression of some RNAs.

MicroRNA (miRNA) is small and noncoding RNA that can regulate gene expression by inhibiting protein translation. Recent research has implicated miRNAs in cancer development and has led to the observation that some miRNAs are reduced in various human cancers and may normally function as tumor suppressors. According to study author Dr. Peter A. Jones from the Norris Comprehensive Cancer Center at the University of Southern California in Los Angeles, "Although the biological importance of miRNA is becoming increasingly apparent, regulation of miRNA expression is not fully understood."

Dr. Jones and his colleagues examined whether miRNAs can be controlled by epigenetic alterations linked to chromatin remodeling. Cancer cells and normal cells were treated with chromatin-remodeling drugs to simultaneously inhibit DNA methylation and histone deacetylation. A subset of miRNAs was upregulated in the cancer cells but not the normal cells. Importantly, miR-127, which is downregulated in 75% of the human cancer cells t ested, was highly induced after treatment with the chromatin-remodeling drugs. Induction of miR-127 resulted in downregulation of BCL6, a known proto-oncogene. Therefore, induction of miR-127 by treatment with chromatin-remodeling drugs may have an anticancer effect.

"Taken together, our results suggest an effect of epigenetic treatment that couples inhibitors of DNA methylation and histone deacetylation to induction of some miRNAs. These miRNAs can potentially regulate expression of target genes that are important in the development and progression of human cancer. Further studies on epigenetic regulation of miRNA expression are necessary, and regulation of miRNA expression by epigenetic treatment may be a novel strategy for prevention or treatment of human cancer," offers Dr. Jones.


'"/>

Source:Cell Press


Related biology news :

1. An HIV Protein Plays a Surprising Role in Gene Activation
2. Activation of thermoreceptors mediates raw garlics burning pungency
3. Activation of a protein solidifies fear memory in the brain
4. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
5. Molecular steps involved in the creation of gene-silencing microRNAs identified
6. Scientists find microRNAs regulate plant development
7. Role of microRNA identified in thyroid cancer
8. Twin molecular scissors link creation of microRNAs with gene-silencing
9. Single microRNA causes cancer in transgenic mouse
10. Pair of microRNA molecules controls major oncogene in most common leukemia
11. Unicellular microRNA discovery
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... Blood centers traditionally see a dangerous drop of ... is a struggle for community blood centers as high schools are out and many ... Commerce is teaming up with the South Texas Blood & Tissue Center ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... clinical trial solutions, today announced safety software company AB Cube has joined ... Solutions business segment to advance technology innovation across life sciences and healthcare. ...
(Date:7/17/2017)... ... 17, 2017 , ... DuPont Pioneer today announced the launch ... (openinnovation.pioneer.com) dedicated to connecting third-party innovators with DuPont Pioneer scientists is now available ... biologicals and digital solutions. , “DuPont Pioneer is building on its long history ...
(Date:7/14/2017)... , ... July 13, 2017 , ... Dr. Joshua Mondlick ... dental implants into his practice, Mondlick Perio, in the Phoenix area. Dr. ... world's first and only FDA cleared laser treatment to re-grow bone and with significantly ...
Breaking Biology Technology: