Navigation Links
Activation of a protein solidifies fear memory in the brain

When activated, a specific protein in the brain enhances long-term storage of fearful memories and strengthens previously established fearful memories, Yale School of Medicine researchers report this week in Nature Neuroscience.

"This report is the first to demonstrate evidence of enhancements in memory reconsolidation in the brain," said the senior author, Jane Taylor, associate professor in the Department of Psychiatry. "Understanding these molecular mechanisms may provide critical insights into psychiatric disorders."

She said recent data suggest that memories can continue to be changed or eliminated long after they have been formed, or consolidated. Based on findings that suggest memories are susceptible to loss after retrieval, a mechanism that is required to maintain and place back memories into long-term storage has been proposed, Taylor said.

"This 'reconsolidation' process is supported by studies suggesting that disruption of cellular functions known to be required for memory storage after retrieval of a memory can cause a specific loss of that memory," she said.

Taylor and her colleagues found that within the amygdala, a brain region known to be critically involved in the creation and storage of fearful memories, selective activation of protein kinase A (PKA) is sufficient to enhance memory reconsolidation and strengthen a previously established fearful memory. Conversely, inhibiting PKA in the amygdala disrupted memory reconsolidation.

"These findings show bidirectional behavioral plasticity after memory retrieval," Taylor said. "Moreover, we find that amygdalar PKA activation does not affect other memory processes after retrieval, including extinction of fear memory, further showing that our findings are specific for a reconsolidation process."

She said enhancement of reconsolidation may contribute to the development of maladaptive memories in psychiatric disorders such as post-traumatic stress disorder, dep
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. An HIV Protein Plays a Surprising Role in Gene Activation
2. Activation of thermoreceptors mediates raw garlics burning pungency
3. Activation of microRNA inhibits cancer gene in human cancer cells
4. New, automated tool successfully classifies and relates proteins in unprecedented way
5. New binding target for oncogenic viral protein
6. Controversial drug shown to act on brain protein to cut alcohol use
7. Timing is everything: First step in protein building revealed
8. UWs Rosetta software to unlock secrets of many human proteins
9. Researchers find how protein allows insects to detect and respond to pheromones
10. Signaling protein builds bigger, better bones in mice
11. Ancient olfaction protein is shared by many bugs, offering new pest control target
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Activation protein solidifies fear memory the brain

(Date:8/28/2014)... in German . ... with the help of sophisticated assembly lines. Mobile assembly carriers, ... part of these assembly lines. In the case of a ... stages arranged in a precise spatial and chronological sequence, resulting ... , The creation of such an assembly line at molecular ...
(Date:8/28/2014)... to alert the world to Global Warming, has called ... stored underground. He says that Carbon Capture, combined with ... to avoid global warming getting out of control over ... York) made the call during his presentation to the ... are meeting to discuss Carbon Capture and Storage. ...
(Date:8/28/2014)... action is needed to ensure safeguards are in place ... PLOS ONE , researchers from Monash University, Stellenbosch ... combining results from different studies - to look at ... to determine whether they actually protect biodiversity. , ... an area from human exploitation made common sense, however, ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Protected areas proven to protect biodiversity 2
... way to fight obesity-related illness has been uncovered, thanks ... Western Reserve University School of Medicine. The collaborators, ... and Cornell University, discovered the essential nutrient vitamin E ... obesity. "The implications of our findings could have a ...
... A research team led by Cornell University,s Creative Machines ... to witness virtual creatures evolving their squishy, muscle-like features in ... concepts from developmental biology and how nature builds complex animals ... of bizarre, simulated robots that evolve a diverse series of ...
... disease affecting a person,s ability to coordinate and control ... in a finger will eventually lead to difficulty in ... without assistance. Since the 1950s research has shown that ... dopamine in their brains, which is involved in sending ...
Cached Biology News:Vitamin E identified as potential weapon against obesity 2Vitamin E identified as potential weapon against obesity 3New research examines connection between inflammatory stimulus and Parkinson's disease 2New research examines connection between inflammatory stimulus and Parkinson's disease 3
(Date:8/29/2014)... According to a new market report published by ... was valued at USD 3,754.6 million in 2012 and is ... a CAGR of 5.9% from 2013 to 2019. , Nearly ... afflicted by bone and joint disorders, and this number is ... and will continue to increase the demand for orthobiologics. Other ...
(Date:8/29/2014)... 29, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or ... financial results for the six months ended June ... in Canadian dollars and presented under International Financial ... Highlights , Announced top-line results related ... endpoint for subjects enrolled in the Phase 2 ...
(Date:8/29/2014)... 29, 2014 Three Lawrence Livermore ... Hydrogen Production R&D Award for their ... water using sunlight. , Shared with collaborators from ... University of Nevada, Las Vegas (UNLV), the award ... of photoelectrochemical solar-hydrogen production and corrosion processes. , ...
(Date:8/29/2014)... MA (PRWEB) August 29, 2014 A ... in the biotech start-up dense realm of Boston-Cambridge, is ... and able investors. James Sherley, the Director of Boston’s ... increasing the local and national visibility of his company ... September 2013. , In addition to a social media ...
Breaking Biology Technology:Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4
... demonstrates company,s commitment to sustainabilityLAS VEGAS, April 22 ... commitment to protecting tomorrow today through its sustainability ... Region for Bayer CropScience, presented Tom Lovelace, United ... million endowment over the next four years to ...
... Cohen to be inducted into National Academy of Sciences for ... Sir Philip Cohen of Scotland,s University of Dundee ... (NAS) during its 146th annual meeting on Saturday, April 25 ... in original scientific research. Sir Philip is one of only ...
... (Pink Sheets: MNCN), an innovative, global wellness solutions company, ... (BPS), operating under the MPS-BioPharm name (MPS), received both ... to utilize MPS, Equity by Design ... fit and purpose related to design, constructability and cleanliness. ...
Cached Biology Technology:Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 2Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 3Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 4United States Recognizes Leading Scottish Scientist for Disease Research 2Mach One BioPharm Process Operating Group Receives Contract From American Beef Processors 2Mach One BioPharm Process Operating Group Receives Contract From American Beef Processors 3
These 25x25 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 102...
... Life Science FLA-8000 Fluorescent Image Analyzer features ... single laser imaging system. This powerful new ... with fluorescent dyes or radioisotopes at resolutions ... laboratories. Speed, image quality and flexibility make ...
...
The model 55D Rocking Shaker provides the same Reliable quality as the 55S, but double the value. The 55D gives you an additional platform with a height of 3.25 in....
Biology Products: