Navigation Links
Activation of a protein solidifies fear memory in the brain

When activated, a specific protein in the brain enhances long-term storage of fearful memories and strengthens previously established fearful memories, Yale School of Medicine researchers report this week in Nature Neuroscience.

"This report is the first to demonstrate evidence of enhancements in memory reconsolidation in the brain," said the senior author, Jane Taylor, associate professor in the Department of Psychiatry. "Understanding these molecular mechanisms may provide critical insights into psychiatric disorders."

She said recent data suggest that memories can continue to be changed or eliminated long after they have been formed, or consolidated. Based on findings that suggest memories are susceptible to loss after retrieval, a mechanism that is required to maintain and place back memories into long-term storage has been proposed, Taylor said.

"This 'reconsolidation' process is supported by studies suggesting that disruption of cellular functions known to be required for memory storage after retrieval of a memory can cause a specific loss of that memory," she said.

Taylor and her colleagues found that within the amygdala, a brain region known to be critically involved in the creation and storage of fearful memories, selective activation of protein kinase A (PKA) is sufficient to enhance memory reconsolidation and strengthen a previously established fearful memory. Conversely, inhibiting PKA in the amygdala disrupted memory reconsolidation.

"These findings show bidirectional behavioral plasticity after memory retrieval," Taylor said. "Moreover, we find that amygdalar PKA activation does not affect other memory processes after retrieval, including extinction of fear memory, further showing that our findings are specific for a reconsolidation process."

She said enhancement of reconsolidation may contribute to the development of maladaptive memories in psychiatric disorders such as post-traumatic stress disorder, dep ression and drug addiction.

"Additionally, the ability to strengthen memories by retrieval has important implications for psychotherapies," she said.


'"/>

Source:Yale University


Related biology news :

1. An HIV Protein Plays a Surprising Role in Gene Activation
2. Activation of thermoreceptors mediates raw garlics burning pungency
3. Activation of microRNA inhibits cancer gene in human cancer cells
4. New, automated tool successfully classifies and relates proteins in unprecedented way
5. New binding target for oncogenic viral protein
6. Controversial drug shown to act on brain protein to cut alcohol use
7. Timing is everything: First step in protein building revealed
8. UWs Rosetta software to unlock secrets of many human proteins
9. Researchers find how protein allows insects to detect and respond to pheromones
10. Signaling protein builds bigger, better bones in mice
11. Ancient olfaction protein is shared by many bugs, offering new pest control target
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... 2017  Genisphere LLC, provider of the 3DNA ... collaborative and sponsored research agreement with the University ... The overall goal of the partnership is to ... designs and formulations after in vivo ... vasculature as well as inflammatory responses, demonstrating various ...
(Date:4/25/2017)... ... April 25, 2017 , ... Franz Inc ... (CL) development tools, and market leader for Semantic Graph Database technology, ... available within the most effective system for developing and deploying applications to solve ...
(Date:4/25/2017)... 25, 2017 Providence ... its novel immune-modulating technology to an undisclosed global pharmaceutical ... Tregitopes, pronounced T·rej·itopes, are a set ... EpiVax CEO Annie De Groot and ... G, an autoimmune disease therapy, Tregitopes are capable ...
(Date:4/25/2017)... Gatos, California (PRWEB) , ... April 25, 2017 ... ... business, Analytical Services and Metrology Partners.     , Covalent’s Analytical Services unit ... Most samples can be measured within 24 hours of receipt. There are no ...
Breaking Biology Technology: