Navigation Links
Achilles heel of the herpes virus possibly found

nism was tricky and near impossible until Fuller's team discovered a type of pig kidney cell that isn't vulnerable to infection by human herpes virus. They searched the genome library to find genes essential to HSV infection, isolated the B5-coding sequence, and figured out how to get pig cells to express the human B5 protein to allow the pig cells to be infected with human herpes virus.

For these studies, Fuller credits the persistence of research team members in working with the genomic library and culture of human and pig cells, especially U-M doctorate graduate Aleida Perez and postdoctoral fellows Qingxue Li and Pilar Perez-Romero. Perez-Romero is first author of one of the two new papers, and a co-author on the other.

The two new papers show that the B5 receptor has important features that could explain why it is important to HSV's ability to fuse with the fluid membrane that encloses every human cell. The researchers were able to show that by placing only the DNA sequence that encodes B5 into HSV-resistant pig cells, they could make the pig cells susceptible to HSV. They were also able to block viral infection of both human cells and susceptible pig cells by adding to cell cultures a synthetic peptide made to mimic the structure of a smaller region of the B5 receptor. This peptide looks like a functional region of B5 and apparently interferes with virus engaging of the cell receptor.

The papers detail how the team isolated and characterized the gene that encodes B5, called hfl-B5, and used the DNA sequence to find out more about the protein structure of the B5 receptor. In the presentation at the International Congress for Virology, Fuller will describe recent findings that further confirm B5's importance in HSV infection.

The virology team reports that the B5 molecule appears to form a shape called a coiled coil. This intricately wound structure, they believe, may be similar to the structure of some fusion proteins of viruses
'"/>

Source:University of Michigan Health System


Page: 1 2 3 4

Related biology news :

1. Researchers develop new method to help find deadly malaria parasites Achilles heel
2. Association of herpesvirus with lung disorder questioned
3. Topical treatment shown to inhibit HIV and herpes simplex virus infection
4. Live vaccines more effective against horse herpes virus
5. Landmark discovery of a Kaposis sarcoma-associated herpesvirus receptor
6. Knowledge of infection may prevent spread of herpes virus
7. Study shows how herpes infects cornea, evades immune cells
8. Research holds promise for herpes vaccine
9. UCSF study will test new vaginal microbicide for herpes and HIV
10. Anti-herpes treatment reduces HIV levels in women infected with both viruses
11. Insulator helps silence genes in dormant herpes virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Achilles heel the herpes virus possibly found

(Date:12/22/2014)... SHELTON, Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile commerce ... consultant, Apollo Robbins for the 2015 International CES ... Apollo Robbins will be at the NXT-ID booth ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading personal genetics ... fine-scale differences in genetic ancestry of individuals from across ... first arrived more than four hundred years ago, ... place for peoples from different continents. This study illuminates how ...
(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor ... leaders such as Intel, Jabra, Atlas, and Scosche to ... These products will be showcased at CES 2015, taking ... . "Our partners choose PerformTek biometrics, ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... the United States have developed a medical model for ... own bone marrow. The research, published in STEM CELLS, ... developed bladders, but also represents another step towards new ... Dr Arun Sharma and Earl Cheng from the Feinberg ...
... STATION - Functional amino acids play a critical role in ... Texas AgriLife Research scientist. In a journal article appearing ... 1:31-37, 2010), Dr. Guoyao Wu, AgriLife Research animal nutritionist ... at Texas A&M University, calls for scientists to "think out ...
... ,trained, bacteria to convert all the main sugars in ... friendly products such as bioplastics. He will be defending ... out in the context of the NWO B-Basic programme, ... November 2010. There is considerable interest in ...
Cached Biology News:New study into bladder regeneration heralds organ replacement treatment 2AgriLife scientist: Functional amino acids regulate key metabolic pathways 2Trained bacteria convert bio-wastes into plastic 2Trained bacteria convert bio-wastes into plastic 3
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
(Date:1/22/2015)... zFlo Motion , a US leader ... exciting product from a new partner. STT-Systems has ... past 15 years, with offerings in the optical-motion capture, 3D ... system (inertial measurement unit), iSen, is opening eyes around the ...
(Date:1/22/2015)... 2015 Controlled Substance Compliance Services (CSCS), ... companies check the legal requirements around using controlled substances ... , As their international operations expand and become ... solutions built as a result of the first phase ...
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... Highlight and ... of Advanced Practices by Leading, Interventionalists, Broadcast from Around the World. - Hear About ... Stent, Results. - See How Many of the Major Fixed Imaging and Stent Manufacturers ... are Embracing IVUS., ...
... PASADENA, Calif., Oct. 22 Maven Biotechnologies, ... label-free multiplexing,immunodiagnostic analysis system, today announced that ... BIOCOM Investor Conference in San Diego,California. Jeffrey ... will,present on Thursday, November 1, 2007 at ...
... America Called Upon to Help One Deserving Facility Win Needed ... Choosing Its Favorite ,Clinical Contender, MALVERN, Pa., Oct. 22 ... images of the clinical challenges in hospitals,across the country to ... diagnostic technology - a magnetic resonance imaging,(MRI) system - are ...
Cached Biology Technology:Volcano Announces Activities at TCT 2007: Expanded Role of IVUS in PCI to be Demonstrated 2Volcano Announces Activities at TCT 2007: Expanded Role of IVUS in PCI to be Demonstrated 3Volcano Announces Activities at TCT 2007: Expanded Role of IVUS in PCI to be Demonstrated 4Maven Biotechnologies, LLC to Present at BIOCOM Investor Conference 2American M.R.I.-DOL: Small Hospitals To Turn The Camera On Themselves In Unique National Contest 2American M.R.I.-DOL: Small Hospitals To Turn The Camera On Themselves In Unique National Contest 3
...
Mitochondria/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Peptide-affinity Purified Polyclonal Antibody to MAML1 / Mastermind Peptide with sequence VLPTCPMAEFALPR, from N Terminus of the protein sequence according to NP_055572....
... age, the autofluorescent pigment lipofuscin accumulates ... types, including neurons. The presence of ... of fluorescence microscopy in the central ... excitation and emission spectra, which overlaps ...
Biology Products: