Navigation Links
Achilles heel of the herpes virus possibly found

B5 receptor, this may be a reason HSV can get into most kinds of cells.

"This may be one central part of the Achilles' heel in interactions of herpes virus with a cell to start infection. We can use the receptor molecule to try to understand the process and perhaps combat infection at this vulnerable site," says A. Oveta Fuller, Ph.D. the leader of the U-M team, senior author on the two papers and an associate professor in the U-M Medical School's Microbiology and Immunology Department. "While we're still a few years away from being able to use this new knowledge to find effective drug candidates, this is a very exciting confluence of discoveries."

The U-M holds a patent on the system and methods that the team used to make the discoveries.

Coincidentally, the U-M team's findings about the B5 receptor are being published at about the same time as an Italian team's reports about a possible 'key' on the herpes simplex virus surface that may match the 'lock' found by the U-M team. The Italian team has identified a region of a viral surface protein that matches the U-M team's predictions of what the virus likely would use to bind and engage the B5 receptor.

"It appears that B5 is a new class of viral receptor. Unlike other viruses so far, HSV seems to have evolved to take advantage of a broadly present cellular protein that has properties like that of known cellular fusion machinery," says Fuller. "No other virus has been shown to use a cellular fusion protein for entry into cells."

She explains that the search for the mechanisms by which HSV enters cells has been hindered by the fact that the virus is very good at entering so many kinds of cells. The many possibilities for virus binding to cells make deciphering the entry process a difficult problem to solve.

The gene that encodes B5 had in fact been sequenced, but not characterized, as part of the Human Genome Project. Discovering its role and studying the HSV entry mecha
'"/>

Source:University of Michigan Health System


Page: 1 2 3 4

Related biology news :

1. Researchers develop new method to help find deadly malaria parasites Achilles heel
2. Association of herpesvirus with lung disorder questioned
3. Topical treatment shown to inhibit HIV and herpes simplex virus infection
4. Live vaccines more effective against horse herpes virus
5. Landmark discovery of a Kaposis sarcoma-associated herpesvirus receptor
6. Knowledge of infection may prevent spread of herpes virus
7. Study shows how herpes infects cornea, evades immune cells
8. Research holds promise for herpes vaccine
9. UCSF study will test new vaginal microbicide for herpes and HIV
10. Anti-herpes treatment reduces HIV levels in women infected with both viruses
11. Insulator helps silence genes in dormant herpes virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Achilles heel the herpes virus possibly found

(Date:7/2/2015)... -- Fingerprint Cards has received an order for ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... smartphone manufacturers in Asia . The order ... guidance of approximately 2,200 MSEK for 2015. Jörgen ...
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/26/2015)... ATL Technology, LLC, a top provider of electromechanical ... use solutions, headquartered in Springville, Utah , ... California corporation with locations in Santa ... Rica ). This acquisition will incorporate MedConx,s ... ATL Technology,s existing facility in Costa Rica ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
... A drug used to treat asthma has been shown ... peptide in the brain that is implicated in the ... University,s School of Medicine. The researchers published their ... an AD Transgenic Mouse Model," in the American ...
... Association for Cancer Research will recognize leaders in the ... in Cancer Research Awards. The 36 recipients will be ... April 2-6. The Minority-Serving Institution Faculty Scholars in ... working at the level of assistant professor or above ...
... virus (HIV), the cause of AIDS, makes use of ... into the host-cell genome, according to a new study ... Cancer Center Arthur G. James Cancer Hospital and ... prevents the virus from completing this critical step in ...
Cached Biology News:Asthma drug could help control or treat Alzheimer's disease 2AACR congratulates recipients of minority-serving institution in cancer research awards 2AACR congratulates recipients of minority-serving institution in cancer research awards 3AACR congratulates recipients of minority-serving institution in cancer research awards 4AACR congratulates recipients of minority-serving institution in cancer research awards 5AACR congratulates recipients of minority-serving institution in cancer research awards 6AACR congratulates recipients of minority-serving institution in cancer research awards 7HIV integration requires use of a host DNA-repair pathway 2
(Date:7/29/2015)... US-Australian drug discovery company, Novogen Limited (ASX: NRT; NASDAQ: ... progressing its ground-breaking technology platforms to Phase 1 clinical ... Company delivers the best value for shareholders. ... the Company currently had an extensive program of activities ... academic partnerships and initiatives, and he was working with ...
(Date:7/29/2015)... July 29, 2015  HealthSouth Corporation (NYSE: ... providers of post-acute healthcare services, offering both facility-based ... of operations for the second quarter ended June 30, ... characterized by strong volume growth in both segments ... said Jay Grinney, President and Chief Executive Officer ...
(Date:7/29/2015)... , July 29, 2015 ... has announced the addition of the "Global ... their offering. The Global Biosimilars Market, ... of the rapidly growing biosimilars market. With the ... striving to minimize costs, biosimilars are being viewed ...
(Date:7/29/2015)... YORK , July 29, 2015  Therapath ... testing, announces increased partnerships with VA and Military ... Epidermal Nerve Fiber Density (ENFD) and Sweat Gland ... small fiber neuropathy ( https://therapath.com/skin ). ... Nerve Fiber Density (ENFD) on punch skin biopsy ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25HealthSouth Reports Results for Second Quarter 2015 26HealthSouth Reports Results for Second Quarter 2015 27
... of the carbon nanotube, a team of researchers has ... that material. , Fixed between two electrodes, the vibrating ... radio--antenna, tunable filter, amplifier and demodulator--to tune in a ... back through an attached speaker. , Functional across a ...
... 1 Pharmasset, Inc.,(Nasdaq: VRUS ) ... first Chief,Development Officer, responsible for coordinating the ... programs. Dr. Rogers joins,Pharmasset from GlaxoSmithKline, where ... of Viral Diseases, responsible for antiviral discovery,activities ...
... SAN FRANCISCO, Calif., Nov. 1 Renovis,Inc. (Nasdaq: ... an overview of the company at the CIBC 18th ... November 7, 2007 at 11:30,a.m. Eastern Standard Time (8:30 ... the live audio broadcast and the subsequent archived audio,recording ...
Cached Biology Technology:World's smallest radio fits in the palm of the hand...of an ant 2World's smallest radio fits in the palm of the hand...of an ant 3Pharmasset Appoints Michael Rogers as Chief Development Officer 2Pharmasset Appoints Michael Rogers as Chief Development Officer 3
... traps a wide variety of solvent vapors that ... glass condensation flask (GCF400) allows for the collection ... easy draining. Rapid cooling time minimizes waiting period., ... quick solvent changes , -50?C ...
... Protein Phosphatase-2A (PPase-2A) is a serine/threonine phosphatase ... is isolated as the heterodimer of 60kDa ... the ability to dephosphorylate the a-subunit of ... PPase-2A has broad substrate specificity and may ...
... high performance spectral scanning multimode reader ... the advanced SkanIt Software it offers ... discovery assay development. Varioskan provides unlimited ... fluorescence and photometric assays and a ...
... of solvent vapors that can contaminate and degrade vacuum ... the collection of liquid into a self contained jar ... Ultra low -104 o C temperature ... Digital Display of temperature ...
Biology Products: