Navigation Links
Achilles heel of the herpes virus possibly found

It's one of the most common viruses in America, and one that causes the most guilt and shame. It can get inside almost any kind of human cell, reproduce in vast numbers, and linger for years in the body, causing everything from recurrent genital blisters to sores around the mouth. Its complications can kill, and it may increase susceptibility to many nerve and brain disorders.

But until now, scientists haven't fully understood how the herpes simplex virus (HSV) manages to do all of this. And that has stood in the way of developing more targeted, effective treatments against it to help those infected.

New research from the University of Michigan Medical School may help change that.

An estimated 45 million Americans have genital herpes and millions more have the more visible oral variety. Once someone is infected, they're infected for a lifetime. New medicines for herpes infection are badly needed; currently, antiviral drugs can quell symptoms of an outbreak, but not eliminate the virus. And, there's increasing evidence that HSV may damage the nerve cells in which it hides between outbreaks, possibly contributing to neurological disease.

In a presentation Sunday at the International Congress of Virology and in two new papers in the Journal of Virology, U-M researchers are reporting the discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells. They've also found the gene that controls the production of that receptor, deciphered some aspects of the receptor's structure, and developed a pig-cell system that could be used to test new anti-herpes drugs.

The findings may help explain why the oral and genital herpes virus has such a successful track record: The receptor, dubbed B5, is made by most cells for another purpose not yet understood. HSV appears to have evolved a way to latch onto it, and fool the cell into letting the virus in. And since most cells express the gene for the
'"/>

Source:University of Michigan Health System


Page: 1 2 3 4

Related biology news :

1. Researchers develop new method to help find deadly malaria parasites Achilles heel
2. Association of herpesvirus with lung disorder questioned
3. Topical treatment shown to inhibit HIV and herpes simplex virus infection
4. Live vaccines more effective against horse herpes virus
5. Landmark discovery of a Kaposis sarcoma-associated herpesvirus receptor
6. Knowledge of infection may prevent spread of herpes virus
7. Study shows how herpes infects cornea, evades immune cells
8. Research holds promise for herpes vaccine
9. UCSF study will test new vaginal microbicide for herpes and HIV
10. Anti-herpes treatment reduces HIV levels in women infected with both viruses
11. Insulator helps silence genes in dormant herpes virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Achilles heel the herpes virus possibly found

(Date:9/22/2014)... More than 7,000 geoscientists will gather in Vancouver, ... Geological Society of America,s 126th Annual Meeting & Exposition ... topics as the transportation of crude oil, earthquake prediction ... field guide, Trials and Tribulations of Life on an ... the Vancouver area. , A broad range of topics ...
(Date:9/21/2014)... the University of California, San Diego, have developed a ... control the activity of genes based on sequences of ... its application to human embryonic cells in a paper ... , "All of our cells have the same blueprint, ... John Whitaker, lead author of the report. "Skin cells ...
(Date:9/19/2014)... Call it the Jimmy Durante of dinosaurs ... nasal profile. The new dinosaur, named Rhinorex ... University and Brigham Young University, lived in what ... during the Late Cretaceous period. , Rhinorex, which ... and a close relative of other Cretaceous hadrosaurs ...
Breaking Biology News(10 mins):Geoscience topics in the spotlight -- Vancouver, BC 2Geoscience topics in the spotlight -- Vancouver, BC 3Geoscience topics in the spotlight -- Vancouver, BC 4Geoscience topics in the spotlight -- Vancouver, BC 5Program predicts placement of chemical tags that control gene activity 2New hadrosaur noses into spotlight 2
... new study reveals that governments in Latin America have ... scant attention to the impact mining, oil exploration and ... people who own the land. The study, which reported ... the 14th Rights and Resources Initiative Dialogue on Forests, ...
... WHAT: Biologist Mary Gehring, Ph.D. is The Pew ... her creative research on epigenetics in plants. Using the ... embryonic development, Gehring,s lab at the Whitehead Institute for ... which genes are turned on and off in seeds. ...
... 21, 2013 Reportlinker.com announces that a ... its catalogue: Global ... This report analyzes the ... Thousands by the following Product Segments: Automated ...
Cached Biology News:Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment 2Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment 3Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment 4Global Fingerprint Biometrics Industry 2Global Fingerprint Biometrics Industry 3Global Fingerprint Biometrics Industry 4Global Fingerprint Biometrics Industry 5Global Fingerprint Biometrics Industry 6Global Fingerprint Biometrics Industry 7Global Fingerprint Biometrics Industry 8Global Fingerprint Biometrics Industry 9Global Fingerprint Biometrics Industry 10Global Fingerprint Biometrics Industry 11Global Fingerprint Biometrics Industry 12Global Fingerprint Biometrics Industry 13Global Fingerprint Biometrics Industry 14Global Fingerprint Biometrics Industry 15Global Fingerprint Biometrics Industry 16Global Fingerprint Biometrics Industry 17Global Fingerprint Biometrics Industry 18Global Fingerprint Biometrics Industry 19
(Date:9/22/2014)... 22, 2014 Invisible Sentinel Inc., ... the food and beverage industries, announced today that ... under a non-exclusive agreement by Enartis, a global ... Enartis, an Esseco Group company headquartered in Trecate, ... California and other global markets for their own ...
(Date:9/22/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... its 2015 fiscal year, which ended Aug. 31, was ... of $7,839,000 in the first quarter of last year. ... 2013, earnings per share in the current quarter were ... First quarter revenues increased 15% to $67,599,000, from the ...
(Date:9/22/2014)... 22, 2014  WIRB-Copernicus Group (WCG), the world,s ... for clinical research, announced today that its Western ... reaccredited by the Association for the Accreditation of ... improve safeguards for clinical research participants. ... , Ph.D., commented, "It is of utmost importance ...
(Date:9/22/2014)... 2014 METTLER TOLEDO is pleased ... measuring device CNS110 ScanTape™ . Replacing a ... offering greater ease and accuracy for transport and ... significantly enhance productivity—an important benefit for load planning ... equals profits. , Usable at any point ...
Breaking Biology Technology:Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 2Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 3Neogen reports 13% net income increase 2Neogen reports 13% net income increase 3Neogen reports 13% net income increase 4Neogen reports 13% net income increase 5Neogen reports 13% net income increase 6Neogen reports 13% net income increase 7Western IRB (WIRB) Awarded AAHRPP Reaccreditation 2ScanTape™ Handheld Dimensioner Increases Processing Volume 2
... ... and sharing of NGS runs; free 2-hour seminar, includes lunch and roundtable discussion, ... (Vocus) February 15, ... ,Learn about sequence data management and the GenomeQuest interactive, web-based tools for comparison, querying, ...
... PHILADELPHIA - Material scientists at the Nano/Bio Interface ... the transduction of optical radiation to electrical current ... of nano-sized molecules of gold, respond to electromagnetic ... project electrical current across molecules, similar to that ...
... ... loving." , ... (PRWEB) February 12, 2010 -- On February 14th, online problem-solving platform ... any discipline and research function—presently employed by an organization, public or private—are invited ...
Cached Biology Technology:GenomeQuest Announces Boston Seminar: Sequence Data Management for Next Generation Sequencing 2Penn material scientists turn light into electrical current using a golden nanoscale system 2No Plans for Valentine's Day? Learn to Love Problems, Says hypios 2
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: