Navigation Links
'Accelerated evolution' converts RNA enzyme to DNA enzyme in vitro

This "evolutionary conversion" provides a modern-day snapshot of how life as we understand it may have first evolved out of the earliest primordial mix of RNA-like molecules-sometimes referred to as the "pre-RNA world"-into a more complex form of RNA-based life (or the "RNA world") and eventually to cellular life based on DNA and proteins. Nucleic acids are large complex molecules that store and convey genetic information, but can also function as enzymes.

While the transfer of sequence information between two different classes of nucleic acid-like molecules-between RNA and DNA, for example-is straightforward because it relies on the one-to-one correspondence of the double helix pairing, transferring catalytic function is significantly more difficult because function cannot be conveyed sequentially. The present study demonstrates that the "evolutionary conversion" of an RNA enzyme to a DNA enzyme with the same function is possible, however, through the acquisition of a few critical mutations.

The study was released in an advance online version of the journal Chemistry & Biology.

Scripps Research Professor Gerald F. Joyce, a member of the Skaggs Institute for Chemical Biology whose laboratory conducted the study, said, "During early life on earth both genetic information and catalytic function were thought to reside only in RNA. In our study, the evolutionary transition from an RNA to a DNA enzyme represents a genuine change, rather than a simple expansion, of the chemical basis for catalytic function. This means that similar evolutionary pathways may exist between other classes of nucleic acid-like molecules. These findings could help answer some fundamental questions concerning the basic structure of life and how it evolved over time."

As Francis Crick, the Nobel laureate who, along with James Watson uncovered the double helix structure of DNA, articulated in 1970, all known organisms operate according to the central dogma of mo
'"/>

Source:Scripps Research Institute


Page: 1 2 3

Related biology news :

1. On a flys wing, scientists tally evolutions winners and losses
2. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
3. Mobile DNA part of evolutions toolbox
4. Gene therapy converts dead bone graft to new, living tissue
5. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
6. Lack of enzyme turns fat cells into fat burners
7. Scientists find missing enzyme for tuberculosis iron scavenging pathway
8. Researchers report new pro-inflammatory role for anti-inflammatory enzyme
9. Purdue researchers use enzyme to clip DNA wires
10. Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
11. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Accelerated evolution converts RNA enzyme DNA enzyme vitro

(Date:2/5/2015)... , 5. Februar 2015 Marken ... Logistikunternehmen und hat eine neue Marketingkampagne gestartet, ... (Clinical Logistics Organization – CLO) der Branche ... lautet First , mit Schwerpunkt auf ... http://photos.prnewswire.com/prnh/20150205/173753 Logo - ...
(Date:2/5/2015)... 26, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... http://www.nxt-id.com/ ) as part of its 2015 marketing and ... launched its new consumer website for Wocketwallet.com earlier this ... of NXT-ID said, "Our new corporate website naturally showcases ...
(Date:2/5/2015)... Jan. 28, 2015 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... RedChip Global Online CEO Conference on January 29 th ... Gino Pereira , CEO of NXT-ID will present and ... the Wocket smart wallet and its full suite of ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3
... has been discovered by a research group at the Sahlgrenska ... an insidious form of glandular cancer usually in the head ... discovery could lead to quicker and better diagnosis and more ... prestigious scientific journal Proceedings of the National Academy of ...
... animals and plants developed different genetic programs for cell ... one at the Swedish University of Agricultural Sciences, has ... programmed cell death in plants and animals are actually ... The findings were published in Nature Cell Biology ...
... in electronics applications, Kansas State University engineers made a ... Berry is a K-State assistant professor of chemical engineering ... single atom thick and discovered just five years ago. ... electronics properties -- Berry and Kabeer Jasuja, a K-State ...
Cached Biology News:New cancer gene discovered 2Cell death occurs in the same way in plants, animals and humans 224-carat gold 'snowflakes' improve graphene's electrical properties 2
(Date:3/2/2015)... 2, 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), ... regenerative medicine, today announced that it will release fourth ... on Tuesday, March 10, 2015 after the close of ... conference call and webcast on Tuesday, March 10, 2015 ... discuss the results and recent corporate developments. ...
(Date:3/2/2015)... 02, 2015 Global Stem ... alliance with Shenzhen HANK Bioengineering Co., Ltd. and ... alliance will establish a stem cells training course ... in September 2015. , Shenzhen HANK is a ... award-winning scientist, microbiologist and virologist, to integrate research, ...
(Date:2/28/2015)... Increasing its efforts to resolve the GMO Controversy ... of The GMO TRUTH podcast on both ITunes and at ... its mission to discover the truth and change the world. ... the truth about the GMOs in our food supply,” adds ... is an expansion of the documentary/investigative film-making methodology in place ...
(Date:2/27/2015)... , Feb. 27, 2015  Pharmacyclics, Inc. (NASDAQ: ... toxicology studies for its newly developed Bruton,s tyrosine ... have been completed. The results of these preclinical ... and Drug Administration. The feedback received from the ... ongoing first-in-human study. Additional preclinical work is required ...
Breaking Biology Technology:Asterias Biotherapeutics to Report Fourth Quarter and Full Year 2014 Results on March 10, 2015 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3The Walk a Mile Project Launches “GMO Truth” Podcast 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3
... Pharmaceuticals Inc. (Nasdaq: VNDA ), a biopharmaceutical ... product candidates for central nervous system disorders, today announced ... March 31, 2009. Vanda reported a net loss ... compared to $7.5 million for the fourth quarter of ...
... Mass., April 29 LaVoie Group, a life ... has been selected as public relations agency of ... Inc. Donna L. LaVoie, President & CEO of ... Profectus during an important stage in the company,s ...
... billions in pest losses annually , ... St. Louis, MO (PRWEB) April ... Divergence, Inc. , has received more than $1.2 million in research grants, ... to further the company,s work on biotech traits for lesion nematode control ...
Cached Biology Technology:Vanda Pharmaceuticals Reports First Quarter 2009 Results 2Vanda Pharmaceuticals Reports First Quarter 2009 Results 3Vanda Pharmaceuticals Reports First Quarter 2009 Results 4Vanda Pharmaceuticals Reports First Quarter 2009 Results 5Vanda Pharmaceuticals Reports First Quarter 2009 Results 6Vanda Pharmaceuticals Reports First Quarter 2009 Results 7Vanda Pharmaceuticals Reports First Quarter 2009 Results 8Vanda Pharmaceuticals Reports First Quarter 2009 Results 9Vanda Pharmaceuticals Reports First Quarter 2009 Results 10LaVoie Group Selected by Vaccine Developer, Profectus BioSciences, as Agency of Record 2Divergence Receives $1.2 Million in Grants, Including NSF Grant to Fund Continuing Nematode Research in Corn 2Divergence Receives $1.2 Million in Grants, Including NSF Grant to Fund Continuing Nematode Research in Corn 3
St. Louis encephalitis Immunogen: St. Louis encephalitis. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Mouse Anti-Gemin2...
5-bromo-2'-deoxyuridine (BrdU) Cell Biology Cell Proliferation Bromodeoxyuridine (BrdU) and Related Products...
Rat CINC-2 alpha/beta Affinity Purified Polyclonal Ab...
Biology Products: