Navigation Links
Absence of critical protein linked to infertility

The absence of a key protein may lead to infertility.

Researchers at the University of Illinois at Urbana-Champaign report that experiments involving mice -- to be detailed in the Proceedings of the National Academy of Sciences -- indicate that the transcription factor protein C/EBPb must be present in the uterus for pregnancy to occur. The study appears online this week at the PNAS Web site.

Without it, they say, an embryo cannot survive in uterine tissue or attach to a mother's blood supply. Other genes also play roles, but C/EBPb is critical for implantation of an embryo, said Milan K. Bagchi, a professor of molecular and integrative physiology.

C/EBPb is scientifically known as CCAAT/Enhancer Binding Protein beta. It is regulated by the hormones estrogen and progesterone. In normal conditions, the protein, driven mostly by progesterone, is expressed rapidly and in large quantities during the critical four-day implantation period in mice, Bagchi said.

During this period, an embryo attaches to the wall of the uterus, advances into it and eventually attaches to the blood supply and forms the placenta. For a successful pregnancy to occur, stromal cells of the uterus must be transformed into decidual cells, which secrete nutrients that allow the embryo to survive until it plugs into the blood supply. C/EBPb is necessary for decidualization, the researchers discovered.

"This protein in the mouse is also in humans," Bagchi said. "We believe it plays a critical role in human pregnancy. It is expressed in the human endometrium at a time that coincides with the time of implantation. We have demonstrated very clearly in the mouse that in the absence of C/EBPb there is no decidualization. We transferred viable mouse embryos from healthy mice into mice lacking the gene, and pregnancy failed."

The project began more than four years ago. First, researchers used DNA microarrays to identify gene expression under normal and abnormal
'"/>

Source:University of Illinois at Urbana-Champaign


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
3. White blood cell waste disposal system plays critical regulatory role
4. Scripps research scientists solve structure of a critical innate immune system protein
5. CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts
6. Scientists map one of biologys critical light-sensing structures
7. Software might revolutionize glucose monitoring in critically ill patients
8. UW scientists unravel critical genetic puzzle for flu virus replication
9. The critical importance of mangroves to ocean life
10. Researches discover gene critical for protection against septic-shock-induced death
11. Iron critical to ocean productivity, carbon uptake
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Absence critical protein linked infertility

(Date:7/11/2014)... There is evidence that under the normal ... and development, maintain neuronal environment, and exhibit ... and neurodegenerative disease. Previous studies have found ... cells after chemical induction have reduced viability, ... application. Prof. Xiaodong Yuan, Kailuan General Hospital, ...
(Date:7/11/2014)... to study the proteins that let nerve cells send ... stumbled upon a biological tactic that may offer a ... a safe and environmentally responsible way. , Their ... one species and harmless for a closely related onesuggests ... without harming beneficial species like bees. A summary of ...
(Date:7/10/2014)... Colo. , June 27, 2014  The ... the National Institute of Standards and Technology (NIST) ... of its academic research and forensic science expert ... The Board is an element of the NIST,s ... members are among the first appointments made to ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... in the field of protein crystallography and a Nobel laureate, was ... His life story, wonderfully told by Georgina Ferry, was recently ... not just a scientist, wrote Dr. Richard E. Dickerson of UCLA ... [H]e was a fine human being with strong family ties ...
... an international symposium in Carolina, Puerto Rico, in conjunction ... Planning on April 29-May 2 so natural resource managers ... of suppressing wildland fires. The Symposium on Fire Economics, ... include economists, policy analysts and fire managers from more ...
... KAN. -- Anyone who has seen Kansas prairies in late ... sunflowers decorating fields and lining roadways, giving Kansas the well ... sunflower is more than just a pretty flower. To scientists, ... Biology at Kansas State University, it is a prime example ...
Cached Biology News:International symposium explores fire suppression economics 2Kansas state flower receives scientific attention 2
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its ... TECHNOLOGY: GLOBAL MARKETS , the global market for digital ... in 2013. This is estimated to grow to $490 ... rate (CAGR) of 28.6%. , New digital PCR technology ... within the broader PCR field. The opportunities presented by ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/10/2014)... 2014 Product and process impurities ... abundance and are often “lost in the noise,” ... Join presenters Dr. Rowel Tobias, Senior Scientist, Protein ... Head of Quality at Nanotherapeutics, Inc., to lear ... speed detection and quantitation while achieving the required ...
(Date:7/10/2014)... Mass. (PRWEB) July 10, 2014 Terascala, ... today announced that Alan Swahn, a former vice president ... executive team as vice president of marketing. Terascala’s software ... Dell and NetApp create the highest performance and most ... been appointed to guide Terascala’s channel expansion and broaden ...
Breaking Biology Technology:Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3
... Research Council (BBSRC) have taken a step towards producing ... livestock - after successfully assembling the virus outside a ... the journal Proceedings of the National Academy of ... develop vaccines with useful new properties. Professor Polly ...
... are closer to reality with the creation of graphene-based ... Rice chemist James Tour lab has created thin films ... lighting. The research was reported in the online edition ... screens may be the "killer app" that finally puts ...
... DIEGO, Aug. 1, 2011 Optimer Pharmaceuticals, Inc. (Nasdaq: ... will present at the Canaccord Genuity Annual Growth Conference ... at the InterContinental Hotel in Boston. (Logo: ... of this presentation will be accessible in the Investors ...
Cached Biology Technology:Scientists take a step towards developing better vaccines for bluetongue 2Scientists take a step towards developing better vaccines for bluetongue 3Dream screens from graphene 2Dream screens from graphene 3
Rabbit anti-T-box 6...
...
... The PowerEase 500 Power Supply ... electrophoresis. It offers extensive programming ... four custom methods for you ... preferences. The simple intuitive PowerEase ...
... The Z-Competent E. coli Transformation Buffer ... of competent E. coli cells for simple ... method completely eliminates the requirement for heat ... transformation can be performed by adding DNA ...
Biology Products: