Navigation Links
ATR checkpoint-activating DNA structure

As published in the April 15th issue of Genes & Development, Dr. Karlene Cimprich and colleagues at Stanford University have determined the minimal DNA structure sufficient to activate the ATR-mediated DNA damage checkpoint.

"We are very excited about these results," says Dr. Cimprich. "The ability to precisely define and manipulate the nature of the checkpoint activating structure in an experimental system will enable us to control, quantitative and probe checkpoint signaling responses in unprecedented ways."

Using Xenopus egg extracts as a cell-free system, the researchers found that single-stranded DNA annealed with primers specifically triggers the ATR-mediated checkpoint response. While many proteins involved in the DNA damage response have been uncovered, this type of structural information is quite novel and valuable. The elucidation of the first defined DNA structure capable of eliciting the ATR checkpoint will aid researchers to further identify additional checkpoint proteins, as well as understand how checkpoint signals are generated and regulated inside the cell.
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Major advance made on DNA structure
2. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
3. Automatic identification of proteins critical features from the structure
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
(Date:3/18/2016)... --> --> ... & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & Detection ... border security market and the continuing migration crisis in the ... has led visiongain to publish this unique report, ... defence & security companies in the border security ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... ... 23, 2016 , ... STACS DNA Inc., the sample tracking software company, today ... Laboratory, has joined STACS DNA as a Field Application Specialist. , “I am ... and COO of STACS DNA. “In further expanding our capacity as a scientific integrator, ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
Breaking Biology Technology: