Navigation Links
APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

ng foreign entering the body," von Andrian explained. "They tell the T cells what to do, how to respond. We have known about some aspects of this process from tissue culture studies, but this has never been observed before in vivo. That has largely been a black box," he said.

His group has explored the first days after a T cell encounters the one antigen it will learn to recognize, von Andrian said. During this time interval, T cells first migrate rapidly and touch every dendritic cell for only a few minutes. This initial phase lasts about eight hours. Then the T cells pick one antigen-presenting dendritic cell and sticks to it for many hours.

After one day, the T cells disengage from the dendritic cell and begin to rapidly reproduce. About three days later, they depart from the lymph node on their search-and-destroy mission.

Homing in on the target

T cells patrol the body by hitching a ride in the blood, methodically stopping at each lymph node like a night security guard making the rounds and checking the doors. There are dendritic cells in the lymph nodes, waiting to present antigens in a way the T cells can recognize.

Each T cell recognizes only one antigen, but preserves that knowledge in its progeny. On average there are 6,000 T cells circulating in the human body that recognize a given antigen. Another 6,000 recognize a different antigen, etc. The human body is estimated to contain 25-100 million distinct T cell clones, he said.

When dendritic cells capture a foreign invader and bring it to the lymph node, many T cells stop by before one is able to recognize it. "The system, while cumbersome, works because of the amazing trafficking where they circle around and look for the presence of anything that might tickle their antigen receptor," von Andrian said.

If the T cells don't recognize the antigen, they hop back in the blood stream and head for the next lymph node. T cells and B cells can live for
'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. “Nano-scissors?laser shows precise surgical capability
3. Clam embryo study shows pollutant mixture adversely affects nerve cell development
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. Study shows nanoshells ideal as chemical nanosensors
6. Gene vaccine for Alzheimers disease shows promising results
7. Flocking together: Study shows how animal groups find their way
8. New drug shows promise as powerful anticancer agent
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Test for early detection of prostate cancer shows promise
11. Mouse gene shows new mechanism behind cardiac infarction in man
Post Your Comments:
(Date:7/11/2014)... at the Department of Energy,s Oak Ridge National ... by R&D Magazine in recognition of the year,s ... the tremendous value of our National Labs," said ... at the National Labs continues to help our ... scientific and technological innovations necessary to remain globally ...
(Date:7/11/2014)... awarded Michael F. Holick, PhD, MD, of Boston University ... Avioli Award. Holick, a professor of medicine, physiology and ... understanding of vitamin D and its role in disease ... the American Society for Bone and Mineral Research (ASBMR) ... It is named for ASBMR,s first president and founding ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... Heart Institute at Intermountain Medical Center have developed a ... cardiologists the ability to see the precise source of ... a condition that affects nearly three million Americans. ... of the heart three dimensionally significantly improves the chances ...
... three are historically recognized as due to plague, but ... 21st centuries AD there were microbiological evidences that the ... "For a long time scholars from different disciplines have ... past pandemics. Only ancient DNA analyses carried out on ...
... May 9, 2013 Wexford Science & Technology, LLC, ... Wake Forest Innovation Quarter , today announced that ... underway represents an additional $150 million investment in downtown ... investment in the Innovation Quarter to more than $250 ...
Cached Biology News:Intermountain Medical Center reseachers develop new 3-D technology to treat atrial fibrillation 2Intermountain Medical Center reseachers develop new 3-D technology to treat atrial fibrillation 3Scientists confirm that the Justinianic Plague was caused by the bacterium Yersinia pestis 2Wexford Science & Technology Makes $150 Million Investment in Wake Forest Innovation Quarter 2Wexford Science & Technology Makes $150 Million Investment in Wake Forest Innovation Quarter 3
(Date:7/11/2014)... , July 11, 2014  Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/10/2014)... Deep Knowledge Ventures last week ... ‘Commercialising Longevity Research’ and welcomed a host of ... Bioscience Innovation Center for the event, organised by ... Ltd. The meeting highlighted the need for both ... age-related disease, as well as the crucial role ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Robert Harman, DVM, ... Medicine company, is proud to announce the relaunch of his ... with a new series called “ What are Stem Cells ... an honest and straightforward foundation in the basics of stem ... decision on the right type of treatment when considering regenerative ...
(Date:7/10/2014)... 10, 2014  Franciscan St. Anthony Health-Crown ... for respiratory monitoring outside the operating room, ... in embracing state-of-the-art patient safety technology. ... breathing and can alert medical caregivers when ... amount of carbon dioxide the patient is ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... CHAPEL HILL, N.C., Oct. 7 Seasoned ... dynamic new set of natural,treatment techniques that are ... such as pain, stress, anxiety, phobias, weight,loss, and ... (PTSD).,Known as "Energy Psychology" (and crossing over into ...
... for Fourth Consecutive Year, INDIANAPOLIS, Oct. ... of the magazine,s Top 500 innovative users ... handful of companies in the biotech,and pharmaceutical ... 86, in the 2008 report,outperformed others in ...
... CARLOS, Calif., Oct. 7 Nektar,Therapeutics (Nasdaq: NKTR ... present at the upcoming Natixis Bleichroeder Second Annual Hidden ... Monday, October 13,2008 at 2:30 p.m. ET., The ... posted,on the Investor Relations, Events Calendar section of the ...
Cached Biology Technology:Upcoming 'Energy Psychology' Event - New Breakthrough 'Do It Yourself' Healing 2InformationWeek Puts Roche Diagnostics on Top 500 Innovative Tech Users List 2