Navigation Links
AIDS-related cognitive impairment exists in two separate forms

athways. Because of this ability to regulate gene expression, miRNAs are believed to play an important role in cancer development, and could serve as targets for novel anti-cancer drugs.

To discover which miRNAs are expressed in colon cancer, compared to normal colon tissue, researchers at Thomas Jefferson University used a microarray chip containing probes for most of the known miRNAs in human and mouse. The investigative team, led by Bruce Boman, M.D., Ph.D., director of Genetic and Preventive Medicine at Jefferson, used the array to first characterize the miRNA expression pattern in intestinal epithelium purified from normal colon tissue.

This epithelial inner lining of the colon contains about 50 million test-tube shaped crypts that line the colon. Colon cancer arises in these crypts, and researchers believe that the cells of origin are the 10-20 immortal stem cells that reside at the bottom of each crypt. The job of these stem cells is to replenish the entire lining of the colon that turns over every five days. However, a mutation in these stem cells produces mutant daughter cells, disorganized tissue architecture, and increased proliferation of crypt cells, which leads to development of colon tumors, Boman said. Hence, they then analyzed malignant colon tissues and found that there are a number of miRNAs that were changed in expression in colon cancer.

Boman, who also directs the G.I. Cancer Program at Jefferson's Kimmel Cancer Center, next purified and microdissected colonic crypts, and compared miRNA expression between the bottom tenth of the crypt, where the stem cells reside, and the upper 9/10s of the crypt. The difference in miRNA signatures between these two crypt regions, they reasoned, would distinguish stem cell from non-stem cell activity. They found a distinct signature of 16 miRNAs that characterizes the crypt bottom. Further analysis revealed that the expression pattern of these 16 miRNAs accurately predicted which colon
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3 4 5 6 7

Related biology news :

1. Combination therapy improves AIDS-related lymphoma outcome
2. An AIDS-related virus tricks cells to become tumors, new Penn study finds
3. Alzheimers cognitive decline slowed
4. Brain networks change according to cognitive task
5. Navigating the brain for sense of direction as paradigm for higher cognitive functions
6. Engineered mouse mimics cognitive aspects of schizophrenia
7. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
8. Master planners in brain may coordinate other areas roles in cognitive tasks
9. Technology exists to keep E. coli out of food
10. New DNA fingerprinting technique separates hemp from marijuana
11. MIT researcher presents new view of how the cortex forms
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: AIDS related cognitive impairment exists two separate forms

(Date:11/7/2014)... professor, biomedical engineering, in the Grove School of ... have identified a molecule that could lead to ... forms of breast cancer. , Triple negative breast ... to aggressive proliferation and metastasis and a lack ... discovered the overexpression of intercellular adhesion molecule-1 (ICAM-1) ...
(Date:11/6/2014)... TALLAHASSEE, Fla. -- A groundbreaking paper from a team ... better understanding of how plants could adapt to and ... The research, published in the latest issue of the ... how chromatin (the complex of DNA and proteins) is ... material, so that some genes are turned on and ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... therapy currently used to treat Helicobacter pylori (H. ... disorders, is unsuccessful in around 25 percent of ... Journal of Gastroenterology, finds that adding a bovine ... yield more effective results, with fewer of the ...
... true spontaneity exist ?in fruit flies. This is what ... 16, 2007 issue of the open-access journal PLoS ONE. ... complex robots which only respond to external stimuli," says ... They are assumed to be input-output devices. "When scientists ...
... but don’t count on them to prevent prostate ... Epidemiology, Biomarkers & Prevention, researchers based at the ... Center report that lycopene, an antioxidant predominately found ... In fact, the researchers noted an association ...
Cached Biology News:Do fruit flies have free will? 2No magic tomato? Study breaks link between lycopene and prostate cancer prevention 2
(Date:11/26/2014)... (PRWEB) November 25, 2014 Whitehouse ... officially joined the Morris County (New Jersey) Chamber ... is a leading business organization in the North ... to further engage some key clients in the ... in the geographic area. Membership enables Whitehouse Laboratories ...
(Date:11/26/2014)... Pittsburgh, PA (PRWEB) November 25, 2014 ... release of its official conference and exposition mobile app, ... available for free download in the App Store for ... as a valuable resource tool before, during and after ... guide containing details on exhibiting companies, technical sessions, Conferee ...
(Date:11/26/2014)... 26, 2014 CURE™ magazine ... on December 5, 2014, in San Francisco prior to ... Heroes event will honor clinicians, caregivers, and advocates who ... neoplasms (MPNs). , Special guest speaker Charles Esten, ... cancer journey at the reception. Over a decade ...
(Date:11/26/2014)... /PRNewswrie/ -- Theravalues Corporation annuncia con orgoglio il lancio ... di Hi Europe 2014 (dal 2 al 4 dicembre, ... della curcumina con la maggiore biodisponibilità di sempre, con ... approvati dalle norme europee. La curcumina è ... ( Curcuma longa ) che è stata associata con ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... a privately-held biotech company using its proprietary platform technology ... gastrointestinal diseases, announced today that it has elected Christopher ... Inc. to its Board of Directors. ... on our Board," said Dr. Barbara Fox, founder, CEO ...
... Inc. (Nasdaq: SGMO ) today announced that the ... Wednesday, May 2, 2012, after the market closes. The press ... p.m. ET, which will be open to the public via ... review the financial results and discuss other business matters. ...
... 2012 The rise of the corporate ... investing are emerging key themes at BioTrinity, the-premier European ... business network which provides comprehensive support for bioscience businesses ... The first day of the conference saw ...
Cached Biology Technology:Avaxia Biologics Elects Christopher Kiritsy to its Board of Directors 2Sangamo BioSciences Announces First Quarter 2012 Conference Call and Webcast 2Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity 2Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity 3
... provides a convenient method to probe conformational changes ... substrates. Thus, the kit may be used to ... as transport substrates for MDR1. Because UIC2 binding ... substrates, the MDR1 Shift Assay can be utilized ...
... wide and long electrophoresis hood ... gel documentation systems. Placed on ... camera in place and provides ... photography on the lab bench. ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... from frozen embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 7microns and ... (3-5mm in diameter) in comparison to core ...
Biology Products: