Navigation Links
AIDS-related cognitive impairment exists in two separate forms

athways. Because of this ability to regulate gene expression, miRNAs are believed to play an important role in cancer development, and could serve as targets for novel anti-cancer drugs.

To discover which miRNAs are expressed in colon cancer, compared to normal colon tissue, researchers at Thomas Jefferson University used a microarray chip containing probes for most of the known miRNAs in human and mouse. The investigative team, led by Bruce Boman, M.D., Ph.D., director of Genetic and Preventive Medicine at Jefferson, used the array to first characterize the miRNA expression pattern in intestinal epithelium purified from normal colon tissue.

This epithelial inner lining of the colon contains about 50 million test-tube shaped crypts that line the colon. Colon cancer arises in these crypts, and researchers believe that the cells of origin are the 10-20 immortal stem cells that reside at the bottom of each crypt. The job of these stem cells is to replenish the entire lining of the colon that turns over every five days. However, a mutation in these stem cells produces mutant daughter cells, disorganized tissue architecture, and increased proliferation of crypt cells, which leads to development of colon tumors, Boman said. Hence, they then analyzed malignant colon tissues and found that there are a number of miRNAs that were changed in expression in colon cancer.

Boman, who also directs the G.I. Cancer Program at Jefferson's Kimmel Cancer Center, next purified and microdissected colonic crypts, and compared miRNA expression between the bottom tenth of the crypt, where the stem cells reside, and the upper 9/10s of the crypt. The difference in miRNA signatures between these two crypt regions, they reasoned, would distinguish stem cell from non-stem cell activity. They found a distinct signature of 16 miRNAs that characterizes the crypt bottom. Further analysis revealed that the expression pattern of these 16 miRNAs accurately predicted which colon
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3 4 5 6 7

Related biology news :

1. Combination therapy improves AIDS-related lymphoma outcome
2. An AIDS-related virus tricks cells to become tumors, new Penn study finds
3. Alzheimers cognitive decline slowed
4. Brain networks change according to cognitive task
5. Navigating the brain for sense of direction as paradigm for higher cognitive functions
6. Engineered mouse mimics cognitive aspects of schizophrenia
7. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
8. Master planners in brain may coordinate other areas roles in cognitive tasks
9. Technology exists to keep E. coli out of food
10. New DNA fingerprinting technique separates hemp from marijuana
11. MIT researcher presents new view of how the cortex forms
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: AIDS related cognitive impairment exists two separate forms

(Date:7/8/2015)... , July 8, 2015  Trovagene, Inc. ... molecular diagnostics, today announced the launch of a ... Company,s Precision Cancer Monitoring℠ (PCM) technology for predicting ... one or a combination of the novel immunotherapy ... (nivolumab), a PD-1 inhibitor. The 50-patient study will ...
(Date:7/2/2015)... , June 25, 2015 ... the addition of the "Natural Language Processing ... (Recognition, IVR, OCR, Pattern & Image Recognition) - ... offering. The key vendors occupying the ... IBM Corporation, Microsoft Corporation, NetBase Solutions, SAS Institute ...
(Date:6/29/2015)... June 24, 2015 Research ... the "Latin America Biomedical Sensors Market - Growth, ... The Latin America Biomedical Sensors market is ... of 2.04% over the period 2014-2020 The ... to the genetic formulation of each individual. These sensors ...
Breaking Biology News(10 mins):Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Latin America Biomedical Sensors Market Report 2015-2020 2
... BOZEMAN Two Montana state University researchers are principal ... find noninvasive ways to study carnivores in the wild. ... was released June 27 with Robert Long and Paula ... at MSU,s Western Transportation Institute. Working with ...
... has shown that enhancing the production of a protein ... neuron death associated with Alzheimer,s, at the expense of ... amyloid-beta protein plaques within the brain is a major ... contribute to disease progression. Normally, special enzymes chew up ...
... type of probe that can image thousands of interactions ... tool to untangle the web of signaling pathways that ... use this to identify new protein partners or to ... the proteins are involved in and during which phase ...
Cached Biology News:
(Date:7/28/2015)... , July 28, 2015  Faced with increasing ... are palliative rather than symptomatic, the global healthcare ... existing therapies capable of curing or significantly changing ... starting to look towards regenerative medicine as a ... new paradigm in human health with the potential ...
(Date:7/27/2015)... ... July 27, 2015 , ... Production of high tenacity ... past few years in the EU. For instance, it surpassed the EUR 106 million ... million mark in 2010. Germany is a major producer, while Italy is a key ...
(Date:7/27/2015)... , July 27, 2015 According ... by Type (Home-brew Media, Pre-formulated Media), by Application (Biobanking, Regenerative ... , Europe , Asia-Pacific ... 2019", The global biopreservation media market was valued at $247.7 ... $571.5 million by 2019, at a CAGR of 18.2% between ...
(Date:7/26/2015)... ... July 26, 2015 , ... Maine Standards Company, LLC ... linearity test kit. The VALIDATE® ANEMIA kit contains Ferritin, Folate, and Vitamin B12 ... the CLSI recommended “equal delta” method for linearity testing and is liquid, ready-to-use. ...
Breaking Biology Technology:Stem Cell Therapy to Redefine Regenerative Medicine, says Frost & Sullivan 2Stem Cell Therapy to Redefine Regenerative Medicine, says Frost & Sullivan 3Stem Cell Therapy to Redefine Regenerative Medicine, says Frost & Sullivan 4Stem Cell Therapy to Redefine Regenerative Medicine, says Frost & Sullivan 5High Tenacity Filament Yarn of Viscose Rayon Consumption to Grow Swiftly in the EU, Forecasts BAC Reports in New Study Available at MarketPublishers.com 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 3Maine Standards Company, LLC Announces Release of VALIDATE® ANEMIA Calibration Verification / Linearity Test Kit 2
... SAN DIEGO, March 30 BrainCells Inc. (BCI), ... using its proprietary platform technology to identify novel ... today the appointment of Dr. Philip Jochelson as ... business officer. Both have extensive experience in the ...
... informed consent software for clinical research trials has named Jovianna ... over 20 years experience driving new pharmaceutical therapeutics and devices ... clinical development to commercialization. , ... ...
... ITMN ) today announced that Daniel G. Welch, ... at Citi,s 4th Annual Biotech Day in New York City ... access a live audio webcast of the presentation, investors and ... page of InterMune,s corporate website at www.intermune.com . ...
Cached Biology Technology:BrainCells Inc. Appoints Philip Jochelson, M.D. Chief Medical Officer and Jason Levin Chief Business Officer 2BrainCells Inc. Appoints Philip Jochelson, M.D. Chief Medical Officer and Jason Levin Chief Business Officer 3Jovianna DiCarlo Named ConsentSolutions, Inc. President & Chief Executive Officer 2
... J. Karn (1995) This volume ... and methods for the study of major ... reverse transcriptase, ribonuclease H, integrase and protease. ... binding assays; Tat and Rev assays; HIV/CD4 ...
Monkey IL-2 ELISPOT Kit with white/opague microtiter plates...
Tachykinin (H-2)...
Human GATA-2 Affinity Purified Polyclonal Ab...
Biology Products: