Navigation Links
A transplant in time

In hemophilia, a mutated gene prevents the production of a critical blood-clotting protein. Treatments for hemophilia and other such genetic diseases, when they exist, may consist of risky blood transfusions or expensive enzyme replacement therapy. But what if the body could be induced to begin producing these proteins, say by transplanting healthy tissue with the abilities that are lacking?

Prof. Yair Reisner and Ph.D. student Anna Aronovich of the Weizmann Institute's Immunology Department, together with colleagues, showed, in research recently published in the Proceedings of the National Academy of Sciences (PNAS), how such a transplant might, in the future, be made feasible.

Previous attempts to treat genetic disease by transplanting (mother to daughter) a spleen, an organ that can manufacture a number of the missing proteins in some such diseases, had made little headway due to the fact that the spleen is home to the immune system's T cells ?cells responsible for the severe immune responses against the recipient known as graft-versus-host disease (GVHD).

Reisner and his team revived the idea, with a twist. Over the past several years, he and members of his lab have been experimenting with tissue transplanted from pig embryos ?a possible substitute for human donor organs. From this, they have learned that for each type of tissue, there is a window of opportunity during which cells taken from the developing embryo can be most successfully transplanted. Tissues taken too early, when they are still fairly undifferentiated, may form tumors, while those taken too late can be identified as foreign, causing the host to reject them.

By taking spleen tissue from embryonic pigs over the course of gestation, they found that the harmful T cells are not present in the tissue prior to day 42 of gestation. The scientists also found that tissue of this age exhibits optimal growth potential as well as secreting factor VIII, the blood-clo tting protein missing in hemophilic patients. Thus, the scientists fixed the ideal time for spleen transplantation at 42 days. Hemophiliac mice with spleen tissue transplanted from pig embryos at this time experienced completely normal blood clotting within a month or two of implantation.

Although a number of problems would need to be surmounted before researchers could begin to think of applying the technique to humans, the Institute team's experiment is "proof of principle" ?evidence that transplanted embryonic tissue, whether human or pig, could one day help the body to overcome genetic diseases.
'"/>

Source:American Committee for the Weizmann Institute of Science


Related biology news :

1. Discoveries by UAB and Florida scientists may help transplanted organs survive longer
2. New type of rejection blocker protects kidneys after transplant
3. Monkeying around to improve organ transplantation
4. Researchers identify genes associated with lung transplant rejection
5. Israeli scientists successfully transplant frozen-thawed ovaries in sheep
6. New cell transplantation technique restores insulin production in diabetics
7. New antifreeze protein found in fleas may allow longer storage of transplant organs
8. Implantable pumps extend lives of patients too sick for transplant
9. Infant transplant patients resist infections that kill adult AIDS patients
10. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
11. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... BOSTON and LONDON , May 23, ... 10 Could See Frontage Boost Efficiency by 40% - ... - Frontage Enforce Quality, Compliance and Traceability Within the ... (CRO) with labs in the United States ... 10 to be deployed across its laboratory facilities. In addition ...
(Date:5/23/2016)... Palo Alto, CA (PRWEB) , ... May 23, ... ... tank and public interest organization focused on molecular nanotechnology, announced the winners for ... honor of pioneer physicist Richard Feynman, are given in two categories, one for ...
(Date:5/20/2016)... , ... May 20, 2016 , ... The leading Regenerative ... its most experienced veterinary clients have treated over 100 of their own patients with ... to provide the highest level of care for their patients. , The veterinarians ...
(Date:5/20/2016)... ... May 20, 2016 , ... Korean researchers say Manumycin ... may offer a new way to treat the disease. Surviving Mesothelioma has just posted ... , Scientists from several Korean institutions based their mesothelioma study on the fact the ...
Breaking Biology Technology: