Navigation Links
A transplant in time

In hemophilia, a mutated gene prevents the production of a critical blood-clotting protein. Treatments for hemophilia and other such genetic diseases, when they exist, may consist of risky blood transfusions or expensive enzyme replacement therapy. But what if the body could be induced to begin producing these proteins, say by transplanting healthy tissue with the abilities that are lacking?

Prof. Yair Reisner and Ph.D. student Anna Aronovich of the Weizmann Institute's Immunology Department, together with colleagues, showed, in research recently published in the Proceedings of the National Academy of Sciences (PNAS), how such a transplant might, in the future, be made feasible.

Previous attempts to treat genetic disease by transplanting (mother to daughter) a spleen, an organ that can manufacture a number of the missing proteins in some such diseases, had made little headway due to the fact that the spleen is home to the immune system's T cells ?cells responsible for the severe immune responses against the recipient known as graft-versus-host disease (GVHD).

Reisner and his team revived the idea, with a twist. Over the past several years, he and members of his lab have been experimenting with tissue transplanted from pig embryos ?a possible substitute for human donor organs. From this, they have learned that for each type of tissue, there is a window of opportunity during which cells taken from the developing embryo can be most successfully transplanted. Tissues taken too early, when they are still fairly undifferentiated, may form tumors, while those taken too late can be identified as foreign, causing the host to reject them.

By taking spleen tissue from embryonic pigs over the course of gestation, they found that the harmful T cells are not present in the tissue prior to day 42 of gestation. The scientists also found that tissue of this age exhibits optimal growth potential as well as secreting factor VIII, the blood-clo tting protein missing in hemophilic patients. Thus, the scientists fixed the ideal time for spleen transplantation at 42 days. Hemophiliac mice with spleen tissue transplanted from pig embryos at this time experienced completely normal blood clotting within a month or two of implantation.

Although a number of problems would need to be surmounted before researchers could begin to think of applying the technique to humans, the Institute team's experiment is "proof of principle" ?evidence that transplanted embryonic tissue, whether human or pig, could one day help the body to overcome genetic diseases.
'"/>

Source:American Committee for the Weizmann Institute of Science


Related biology news :

1. Discoveries by UAB and Florida scientists may help transplanted organs survive longer
2. New type of rejection blocker protects kidneys after transplant
3. Monkeying around to improve organ transplantation
4. Researchers identify genes associated with lung transplant rejection
5. Israeli scientists successfully transplant frozen-thawed ovaries in sheep
6. New cell transplantation technique restores insulin production in diabetics
7. New antifreeze protein found in fleas may allow longer storage of transplant organs
8. Implantable pumps extend lives of patients too sick for transplant
9. Infant transplant patients resist infections that kill adult AIDS patients
10. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
11. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... ... NDA Partners Chairman Carl Peck, MD , announced today that John W. ... Center for Devices and Radiological Health and recognized leader in the medical device, pharmaceutical ... his FDA experience, Dr. Sheets served in senior technical leadership roles in a series ...
(Date:8/21/2017)... USA (PRWEB) , ... August 20, 2017 , ... ... the Journal of Biomedical Optics (JBO) starting 1 January 2018. The journal is ... of Biomedical Optics publishes papers on the use of modern optical technology for ...
(Date:8/21/2017)... ... August 21, 2017 , ... The team at ... educational webinar, in which attendees will learn about the assembly and topological architecture ... with an overview of the development and validation of new high-quality recombinant monoclonal ...
(Date:8/17/2017)... Westlake Village, CA (PRWEB) , ... August 17, ... ... biopsy technology for cancer research and personalized medicine, today announced the launch of ... in Kansas City, Missouri. The study’s goal is to evaluate the potential for ...
Breaking Biology Technology: