Navigation Links
A switch between life and death

The breakthrough came as Barry Thompson from Stephen Cohen's group at EMBL looked at a recently discovered signaling pathway called "Hippo."

"Hippo acts as a switch between cell division and death," says Barry Thompson, "If the pathway is too active, tissues overgrow because too many cells divide and too few die. But until now, we hadn't found a connection between the signals and the cellular machinery that drives growth."

Using sophisticated genetic techniques, Thompson and Cohen established that a small molecule, a microRNA called bantam, makes this link. Without bantam, tissues grow too slowly and remain smaller than normal. The amount of bantam produced by the cell directly depends on the amount of traffic on the Hippo signaling pathway, and higher levels of bantam prompt more cell division.

"Bantam is an unusual type of RNA molecule," Thompson says. "Normally, RNAs go on to make protein, but bantam is different. Its job is to regulate other RNAs by attaching itself to them; the result is that they block their expression into proteins. In this case, those proteins would go on to shut down cell division. With bantam around, the brake is off, and they continue to divide."

Cohen and his lab have been studying microRNAs like bantam for some time because of their important role in the regulation of many vital processes across species. The next step will be to identify the RNAs that bantam docks onto to control. This will provide a more complete view of the Hippo pathway and may provide insights into the central role it plays in tissue growth and cancers in humans and other organisms.


'"/>

Source:European Molecular Biology Laboratory


Page: 1

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
3. Beetle-inspired switch uses water for bonding
4. Single gene is genetic switch for fly sexual behavior
5. UT Southwestern researchers discover master switch in cell death
6. A dimmer switch for genes
7. Scientists discover the molecular switch for nerve cells insulating jelly rolls
8. Switching to new anti-bacterial targets: Riboswitches
9. Hot-spring bacteria flip a metabolic switch
10. Animal models show that anabolic steroids flip the adolescent brains switch for aggression
11. Master genetic switch found for chronic pain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/11/2017)... , Jan. 11, 2017  Michael Johnson, co-founder of Visikol Inc. ... Group, Inc., has been named to the elite "Forbes 30 Under ... one of 600 people in 20 fields nationwide to be recognized ... the 15,000 applicants were selected. ... He is currently a PhD candidate at Rutgers University. ...
(Date:1/6/2017)... 2017  Delta ID Inc., a leader in consumer-grade ... automotive at CESĀ® 2017. Delta ID has collaborated with ... the use of iris scanning as a secure, reliable ... in a car, and as a way to elevate ... Delta ID and Gentex will demonstrate (booth #7326 ...
(Date:1/3/2017)... 3, 2017 Onitor, provider of digital health ... Track, an innovative biometric data-driven program designed to aid ... at the 2017 Consumer Electronics Show (CES) in ... the U.S., the World Health Organization (WHO), have identified ... adults who are overweight or obese. WHO also states ...
Breaking Biology News(10 mins):
(Date:1/19/2017)...  Market Research Future has a half cooked research report on ... growing rapidly and expected to reach USD 450 Million by the ... ... has been assessed as a swiftly growing market and expected that ... coming future. There has been a tremendous growth in the prevalence ...
(Date:1/19/2017)... ... January 19, 2017 , ... November ... to leading biopharmaceutical and medical device manufacturers and regulators, is proud to announce ... Part 11-compliant email client designed to provide product vigilance departments with the flexibility ...
(Date:1/19/2017)... ... 18, 2017 , ... LabRoots , the leading provider ... world, was today awarded the "Best Science & Technology Social Networking Service 2016" ... decided upon by a dedicated team of researchers and analysts. , The 2016 ...
(Date:1/19/2017)... 2017 Acupath Laboratories, Inc., a leading provider ... an Executive Committee that will guide the company,s vision ... John Cucci , a 15-year veteran of the anatomic ... Development to Chief Sales Officer .  Prior to ... senior sales leadership roles at several leading lab industry ...
Breaking Biology Technology: