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A step forward in the fight against bacterial infections

ntact with LPS is a profuse production of type 1 interferons. These proteins play an important role in the regulation of immunity. The Ghent researchers administered 10 times the lethal dose of LPS to the mutant mice, without deadly consequences. This finding could not be attributed to an alteration in TLR4, but to a reduced production of type 1 interferons. To verify this, Mahieu and her colleagues administered these interferons preventatively to the mice − which made the animals susceptible to LPS once again. Thus, this research shows that the mice are no longer able to produce large quantities of type 1 interferons − with the consequence that an inflammation fails to arise, demonstrating the importance of type 1 interferons to the inflammation process. On the other hand, the mice produce just enough interferons to activate the immune system against the bacteria, so that the mice are protected against bacterial infections.

Another step forward in the battle against bacterial infections

The results of this research are very relevant to the quest for new therapeutics for bacterial infections. The mutant mice display a combination of important characteristics: they are resistant to LPS, but they still recognize and destroy pathogens. The limited quantity of type 1 interferons enables the mice to cope with a lethal shock resulting from inflammation, but this small quantity also ensures that immunity is preserved. A next step in combating bacterial infections is to uncover the mechanism behind this reduced production.


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Source:VIB, Flanders Interuniversity Institute of Biotechnology


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