Navigation Links
A resetting signal keeps circadian rhythm on track in Drosophila fruit flies

A Brandeis University study published this week in Nature shows for the first time that a molecular signal maintains coherence among brain clock cells that regulate daily activity of Drosophila melanogaster (fruit flies). The two key groups of neurons control morning and evening activity and are maintained in synch even when the flies are plunged into darkness for extended periods of time.

This daily resetting signal flows from the morning to the evening cells and maintains a 12-hour difference between the timing of morning and evening activity, without the need for any environmental cues. The Brandeis researchers came to this conclusion by speeding up only the morning cell clock or only the evening cell clock. The results showed clearly that these two clocks always remained coupled in a network that was governed by the morning cell signal.

"We think it very likely that something similar is occurring in the brain of mammals, including humans, because their clock neurons also maintain remarkable coherence," said Professor Michael Rosbash, director of the National Center for Behavioral Genomics at Brandeis, and a Howard Hughes Medical Institute investigator. "However, circadian brain anatomy in mammals is much more complicated and the tools much too primitive to allow a similar network approach at this time. Flies are state-of-the art. Fortunately, their circadian clocks and even neural mechanisms are quite conserved with mammals."

"We were curious about how these brain cells stay synchronized, so we controlled the way time was ticking in individual clocks: we made the morning cells run faster and the evening cells relatively slower, and the other way around," explained researcher Dan Stoleru. "In this fashion, we introduced phase differences between them. It turned out that no matter the manipulation, the morning cells set the pace of the entire system, so that the rhythm always stayed on track."

The study showed that the mornin g clock resets the evening clock every day, without changing the intrinsic speed of the evening clock. Between daily resets, therefore, the evening cells time evening activity with their own clock, but they will always start counting time from the moment they were reset by the morning cells. In other words, the evening clock triggers the alarm at its own pace, but it is the morning clock which sets the alarm every day.

"So if you are looking over several days, only one period will be observed ?the one dictated by the morning clock," Stoleru said.

Research by the same Brandeis team, published last year in Nature, had shown that two distinct groups of clock neurons determine morning and evening activity. The present study greatly advanced the understanding of how temporal coherence between these two cell groups, and between their behavioral outputs, is achieved.


'"/>

Source:Brandeis University


Related biology news :

1. Travelers can avoid jet lag by resetting their body clocks
2. Plants respond similarly to signals from friends, enemies
3. Bound for destruction: Ubiquitination protects against improper Notch signaling
4. Viral protein influences key cell-signaling pathway
5. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
6. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
7. Scientists discover that three overlapping signals in embryo help get the backbone right
8. After a time-shift, mixed signals from the circadian clock
9. Researchers make surprise discovery that some neurons can transmit three signals at once
10. Structure-building cell signals also may influence learning and memory
11. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... LOS ANGELES , June 22, 2016 ... of identity management and verification solutions, has ... cutting edge software solutions for Visitor Management, ... ® provides products that add functional ... The partnership provides corporations and venues with ...
(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
(Date:6/9/2016)... an innovation leader in attendance control systems is proud to announce the introduction of ... make sure the right employees are actually signing in, and to even control the ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... GUELPH, ON , June 27, 2016 /PRNewswire/ - BIOREM ... it has been advised by its major shareholders, Clean ... LP, United States based venture ... common shares of Biorem (on a fully diluted, as ... for the disposition of their entire equity holdings in ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
Breaking Biology Technology: